Table 3 Heterogeneity assessment
From: Accumulate evidence for IP-10 in diagnosing pulmonary tuberculosis
Covariate | Studies | Sensitivity (95%) | Specificity (95%) | P Value (Bivariate Model) |
|---|---|---|---|---|
TB high-burden country | ||||
 Yes | 14 | 0.86 (0.81–0.92) | 0.86 (0.80–0.93) | 0.83 |
 No | 10 | 0.85 (0.76–0.93) | 0.89 (0.83–0.96) | |
Design type | ||||
 Cohort | 17 | 0.84 (0.78–0.90) | 0.89 (0.83–0.94) | 0.55 |
 Cross-sectional/case-control | 7 | 0.89 (0.82–0.96) | 0.85 (0.75–0.95) | |
Age | ||||
 Adults | 14 | 0.88 (0.82–0.94) | 0.87 (0.80–0.93) | 0.59 |
 Children and adults/children | 10 | 0.83 (0.74–0.91) | 0.89 (0.82–0.96) | |
IP-10 method | ||||
 Multiplex cytokines assay | 10 | 0.84 (0.75–0.92) | 0.89 (0.82–0.96) | 0.73 |
 ELISA | 14 | 0.87 (0.81–0.93) | 0.87 (0.80–0.93) | |
IP-10 condition | ||||
 Stimulated | 14 | 0.86 (0.80–0.92) | 0.86 (0.79–0.93) | 0.72 |
 Unstimulated | 10 | 0.86 (0.78–0.93) | 0.90 (0.83–0.96) | |
HIV-infected | ||||
 Yes/some | 5 | 0.90 (0.82–0.98) | 0.88 (0.79–0.98) | 0.53 |
 No | 19 | 0.84 (0.79–0.90) | 0.87 (0.82–0.93) | |