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Table 3 Heterogeneity assessment

From: Accumulate evidence for IP-10 in diagnosing pulmonary tuberculosis

Covariate Studies Sensitivity (95%) Specificity (95%) P Value (Bivariate Model)
TB high-burden country
 Yes 14 0.86 (0.81–0.92) 0.86 (0.80–0.93) 0.83
 No 10 0.85 (0.76–0.93) 0.89 (0.83–0.96)
Design type
 Cohort 17 0.84 (0.78–0.90) 0.89 (0.83–0.94) 0.55
 Cross-sectional/case-control 7 0.89 (0.82–0.96) 0.85 (0.75–0.95)
Age
 Adults 14 0.88 (0.82–0.94) 0.87 (0.80–0.93) 0.59
 Children and adults/children 10 0.83 (0.74–0.91) 0.89 (0.82–0.96)
IP-10 method
 Multiplex cytokines assay 10 0.84 (0.75–0.92) 0.89 (0.82–0.96) 0.73
 ELISA 14 0.87 (0.81–0.93) 0.87 (0.80–0.93)
IP-10 condition
 Stimulated 14 0.86 (0.80–0.92) 0.86 (0.79–0.93) 0.72
 Unstimulated 10 0.86 (0.78–0.93) 0.90 (0.83–0.96)
HIV-infected
 Yes/some 5 0.90 (0.82–0.98) 0.88 (0.79–0.98) 0.53
 No 19 0.84 (0.79–0.90) 0.87 (0.82–0.93)