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Table 1 The main characteristics of included studies

From: Accumulate evidence for IP-10 in diagnosing pulmonary tuberculosis

Author Year Country TB high-burden country Study design Age Number of participants TB site Non-TB status IP-10 cut-off Reference standard
Zhao Y [7] 2018 China yes prospective cohort children and adult 41 PTB healthy controls not report A, B
Zhao Y [7] 2018 China yes prospective cohort children and adult 242 PTB healthy controls not report A, B
Zhao Y [7] 2018 China yes prospective cohort children and adult 174 PTB healthy controls not report A, B
Blauenfeldt T [13] 2016 Denmark no prospective cohort adult 225 PTB healthy controls 2300 pg/ml B
Jacobs R [14] 2016 South Africa yes prospective cohort adult 55 PTB non-TB controls (other respiratory diseases) >  746.6 pg/ml B
Lee K [15] 2015 Republic of Korea no cross-sectional adult 457 PTB healthy controls 68.5 pg/ml A
Azab NY [16] 2013 Egypt no prospective cohort adult 30 PTB healthy controls not report B
Wang X [17] 2012 China yes cross-sectional adult 334 PTB healthy controls 589 pg/ml A, B/C
Hong JY [18] 2012 Republic of Korea no cross-sectional adult 78 PTB healthy controls 2811/119.5 pg/ml A, B
Kabeer BSA [19] 2012 India yes retrospective case control adult 277 PTB healthy controls not report A, B
Luo J [20] 2018 China yes prospective cohort adult 100 PTB healthy controls 631.4 pg/ml A, B
Manna MPL [21] 2018 Italy no retrospective cohort children and adult 47 PTB non-TB controls (other non-TB pulmonary infections) >  6557 pg/ml A, D
Balcells ME [22] 2018 Chile no prospective cohort children and adult 61 PTB household contacts (QFT -) >  42.6 pg/ml A, B
Nonghanphithak D [23] 2017 Thailand yes prospective cohort adult 87 PTB healthy controls 6319, 2372, 6964 pg/ml A, B, D
Biraro IA [24] 2015 Uganda yes prospective cohort children and adult 168 PTB household contacts (TST and QFT -) 4858 pg/ml, 0.47 A
Wergeland I [25] 2015 Norway no prospective cohort adult 58 PTB non-TB controls (HIV-infected) 2532 pg/ml A, B
Petrone L [26] 2015 Uganda yes prospective cohort children 52 PTB healthy controls 209.1 pg/ml A, B
Latorre I [27] 2014 Spain no retrospective cohort children 149 PTB healthy controls 2400 pg/ml A
Wang S [28] 2012 China yes cross-sectional children and adult 142 PTB healthy controls 451.3 pg/ml A, B
Jeong YH [29] 2015 Republic of Korea no cross-sectional adult 59 PTB healthy controls 0.7906 A, C
  1. Abbreviations: TB Tuberculosis, PTB Pulmonary tuberculosis, QFT QuantiFERON-TB gold test, TST Tuberculin skin test, HIV Human immunodeficiency virus, IP-10 Interferon gamma-induced protein 10, A MTB positive cultures, B Sputum smear microscopy and/or acid-fast bacilli (AFB) positive, C Pathological examination, D Genexpert MTB/RIF