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Table 3 Diagnostic Accuracy of Different Methods for Prediction of Liver Fibrosis

From: The liver fibrosis index is superior to the APRI and FIB-4 for predicting liver fibrosis in chronic hepatitis B patients in China

  Optimized cut off value Sensitivity (%) Specificity (%) AUC (95%CI) P value of ROC contrast test
F0-F1 vs. F2-F4
 APRI 0.58 62.38 71.29 0.73 (0.63, 0.76) < 0.001
 FIB-4 4.68 60.63 65.56 0.74 (0.68, 0.80) < 0.001
 LFI 2.61 81.62 80.47 0.77 (0.69, 0.82) < 0.001
F0-F2vs.F3-F4
 APRI 1.53 62.65 70.26 0.70 (0.63, 0.74) < 0.001
 FIB-4 5.76 64.48 63.19 0.70 (0.66, 0.71) 0.001
 LFI 3.20 69.82 74.26 0.73 (0.65, 0.77) < 0.001
F0-F3 vs. F4
 APRI 2.07 60.73 62. 68 0.75 (0.69, 0.84) < 0.001
 FIB-4 7.83 59.08 58.83 0.76 (0.66, 0.79) < 0.001
 LFI 3.92 82.29 83.71 0.79 (0.70, 0.88) < 0.001
  1. Optimized cut off value: were chosen by Youden Index which was the optimal combination of sensitivity and specificity, APRI aspartate aminotransferase-to-platelet ratio index, FIB-4 fibrosis index based on four factors, LFI liver fibrosis index