Table 1 Characteristics of analyzed patients
Sepsis without malignancy (n = 83) | Sepsis with stage I/II solid malignancy (n = 83) | p-value | |
|---|---|---|---|
Male gender (n, %) | 56 (67.5) | 53 (63.9) | 0.744 |
Age (years, mean ± SD) | 64.0 ± 18.4 | 69.10 ± 9.85 | 0.435 |
APACHE II score (mean ± SD) | 21.2 ± 8.1 | 21.9 ± 6.9 | 0.782 |
SOFA score (mean ± SD) | 8.47 ± 3.74 | 8.52 ± 3.39 | 0.915 |
CCI (mean ± SD) | 4.70 ± 3.37 | 5.64 ± 2.27 | 0.057 |
White blood cells (/mm3, mean ± SD) | 15,783.3 ± 8868.6 | 14,121.2 ± 8977.1 | 0.120 |
Infection site (n, %) | |||
Hospital-acquired pneumonia | 26 (31.3) | 25 (30.1) | 1.00 |
Primary bacteremia | 15 (18.1) | 15 (18.1) | 1.00 |
Intrabdominal infection | 14 (16.9) | 21 (25.3) | 0.253 |
Community-acquired pneumonia | 14 (16.9) | 10 (12.0) | 0.509 |
Acute pyelonephritis | 5 (6.0) | 3 (3.6) | 0.720 |
Acute bacterial skin and soft tissue infection | 4 (4.8) | 0 (0) | 0.120 |
Bacterial meningitis | 1 (1.2) | 1 (1.2) | 1.00 |
Other | 4 (4.8) | 8 (9.6) | 0.369 |
Organ dysfunction (n, %) | |||
Septic shock | 56 (67.5) | 56 (67.5) | 1.00 |
Acute respiratory distress syndrome | 44 (53.0) | 46 (55.4) | 0.876 |
Acute kidney injury | 22 (26.5) | 12 (14.5) | 0.083 |
Disseminated intravascular coagulation | 17 (20.5) | 22 (26.5) | 0.464 |
Bloodstream isolate (n, %) | |||
Acinetobacter baumannii | 7 (8.4) | 9 (10.8) | 0.793 |
Klebsiella pneumoniae | 3 (3.6) | 5 (6.0) | 0.720 |
Pseudomonas aeruginosa | 3 (3.6) | 5 (6.0) | 0.720 |
Staphylococcus aureus | 3 (3.6) | 0 (0) | 0.245 |
Enterococcus faecalis | 3 (3.6) | 3 (3.6) | 1.00 |
Enterococcus faecium | 1 (1.3) | 3 (3.6) | 0.621 |
Other | 9 (10.8) | 6 (7.2) | 0.600 |
Urine isolate (n, %) | |||
Klebsiella pneumoniae | 2 (2.4) | 2 (2.4) | 1.00 |
Acinetobacter baumannii | 3 (3.6) | 1 (1.3) | 0.620 |
Tracheobronchial secretions isolate (quantity > 105 cfu/ml) | |||
Klebsiella pneumoniae | 4 (4.8) | 8 (9.6) | 0.370 |
Pseudomonas aeruginosa | 6 (7.2) | 7 (8.4) | 1.00 |
Acinetobacter baumannii | 14 (16.9) | 22 (26.5) | 0.187 |
Staphylococcus aureus | 3 (3.6) | 0 (0) | 0.245 |
Other | 6 (7.2) | 4 (4.8) | 0.746 |
Co-morbidities (n, %) | |||
Type 2 diabetes mellitus | 22 (26.5) | 16 (19.3) | 0.356 |
Chronic heart failure | 23 (27.7) | 18 (21.7) | 0.472 |
Chronic obstructive pulmonary disease | 17 (20.5) | 17 (20.5) | 1.00 |
Chronic renal disease | 11 (13.3) | 6 (7.2) | 0.306 |
Coronary heart disease | 12 (14.5) | 11 (3.3) | 1.00 |
Vascular hypertension | 18 (21.7) | 21 (25.3) | 0.715 |
Atrial fibrillation | 9 (10.8) | 8 (9.6) | 1.00 |
Stroke | 13 (15.7) | 10 (12.0) | 0.654 |
Time (hours) from sepsis onset to the administration of the first dose of antimicrobials (median, range) | 5 (0–125) | 6 (0–216) | 0.112 |
Time (hours) from onset of vasopressors to the administration of the first dose of antimicrobials (median, range) | 2.7 (0–55) | 2.8 (0–168) | 0.444 |
Susceptibility of the isolated pathogen to the administered antimicrobials based on antibiogram (n, %) | 22 (26.5) | 22 (26.5) | 1.00 |