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Table 2 Assay performance simulating high-volume CT/NG testing (n = 555*), results for Chlamydia trachomatis

From: High-volume workflow and performance comparisons for Chlamydia trachomatis and Neisseria gonorrhoeae testing using automated molecular platforms

  Aptima Combo 2  
CT positive CT negative Total
cobas CT/NG CT positive 31 1 32
CT negative 0 523 523
Total 31 524 555
PPA (95% CI), NPA (95% CI) 100 (88.8, 100) 99.8 (98.9, 100)  
OPA (95% CI) 99.8 (99, 100)   
p-value 1   
  1. *One CT specimen was not included in the CT method correlation because of an equivocal result generated by the Aptima Combo 2 assay (cobas CT/NG: “CT Positive” and Aptima Combo 2: “CT UNBEST”)
  2. Comparison of cobas CT/NG for use on the cobas 6800 system and Aptima Combo 2 on the Panther system
  3. Calculated using McNemar’s test
  4. Abbreviations: CI confidence interval, CT Chlamydia trachomatis, NPA negative percent agreement, OPA overall percent agreement, PPA positive percent agreement