Table 1 Reported cases of Cellulosimicrobium species (or Oerskovia) infections
From: Infections due to Cellulosimicrobium species: case report and literature review
Ref | Age/sex | Predisposing condition or underlying disease | Species (specimen) | Type of infection | Foreign body (time before)/ removal | Antibiotic therapya and surgery | Failed antibiotic therapy aloneb | Outcome |
|---|---|---|---|---|---|---|---|---|
[9] | 68 yr./M | Aortic insufficiency, prosthetic valve, Crohn’s, ankylosing spondylitis, steroids | O. turbata (blood, prosthetic heart valve) | Endocarditis | Prosthetic heart valve (2 mo)/yes | PEN, AMP + ERY, SXT, SXT + AMP, SXT + AMX Aortic valve replacement | Yes | Cure |
[10] | 3 yr./M | Acute myelogenous leukemia, neutropenia | O. turbata (blood) | CVC-related bacteremia | CVC (1 mo)/yes | AMK | Yes | Cure |
[11] | 40 yr./F | Crohn’s, short bowel syndrome | Oerskovia species (blood, TPN solution) | CVC-related bacteremia | CVC (9 mo)/no | VAN+GEN + MET, VAN | No | Cure |
[12] | 40 yr./M | Alcoholism, cirrhosis | O. xanthineolytica (blood) | Bacteremia | None | VAN+GEN + CLI | NA | Cure |
[13] | 54 yr./F | Metastatic breast cancer, chemotherapy | O. xanthineolytica (blood) | CVC-related? bacteremia | CVC (4 mo) (unclear role)/no | CXM, VAN | No | Cure |
[14] | 49 yr./F | Metastatic colonic cancer | O. xanthineolytica (blood, CVC tip) | CVC-related bacteremia | CVC (15 mo)/no | VAN | No | Cure |
[15] | 27 yr./M | AIDS, neutropenia | O. turbata (blood) | CVC-related bacteremia | CVC (4 wk)/yes | IMP+AMK | NA | Cure |
[16] | 53 yr./F | Non-Hodgkin’s lymphoma, BMT, neutropenia | O. xanthineolytica (blood, CVC tip) | CVC-related bacteremia ➔Endocarditis | CVC (1 yr)/yes | DOX, CLI, MPM, AMX + SXT, IMP+AMK, CLA + RIF, PEN | NA | Death |
[17] | 64 yr./F | Peritonitis carcinomatosa | O. xanthineolytica (blood) | Bacteremia | None | PTZ, PTZ + NET, VAN+NET, PTZ + NET | NA | Cure |
[18] | 31 yr./M | CRF, renal transplant, DM | O. xanthineolytica (blood, heart valve) | CVC-related bacteremia ➔Endocarditis | CVC (NR)/yes | AMS, AMS + VAN, CAZ + VAN, VAN Aortic valve replacement | NA | Cure |
[19] | 13 yr./M | Short bowel syndrome | C. cellulans (blood) | CVC-related bacteremia | CVC (NR)/no | VAN+CTX, VAN+GEN, VAN, VAN+RIF | No | Cure |
[20] | 1 d/M | None | C. cellulans (blood) | Bacteremia | None | CTX + AMP, VAN | NA | Cure |
[21] | 81 yr./M | Aortic stenosis, prosthetic valve | C. funkei (blood) | Endocarditis | Prosthetic heart valve (7 mo)/no | AMC, VAN+GEN | Yes | Death |
[22] | 59 yr./M | COPD, arteriosclerosis | C. cellulans (blood) | CVC-related bacteremia | CVC (7 d)/yes | VAN+PTZ | NA | Death |
[23] | 80 yr./F | CRF, hemodialysis | C. cellulans (blood) | CVC-related bacteremia | CVC (NR)/yes | VAN | Yes | Curec |
[24] | 59 yr./F | Metastatic rectal cancer | C. cellulans (blood) | CVC-related bacteremia | CVC (NR)/yes | VAN, VAN+IMP, VAN | Yes | Cure |
[25] | 44 yr./F | T-cell lymphoma, BMT, neutropenia | Cellulosimicrobium species (blood, CVC tip) | CVC-related bacteremia | CVC (5 wk)/yes | VAN+CPM, VAN+MPM, VAN | NA | Death |
[26] | ≈50 yr./M | DM | Oerskovia species (blood) | Osteomyelitis | None | VAN+CPM + MET, SXT Amputation | NA | Cure |
[27] | 47 yr./F | Kidney trouble? | Oerskovia species (kidney) | Pyonephrosis | None | Nephrectomy | NA | Cure |
[28] | 47 yr./M | Penetrating eye injury, steroids | O. xanthineolytica (vitreous humor) | Endophthalmitis | Intraocular metallic object (12 d)/yes | GEN (sc), PEN, PEN+CFL Vitrectomy | NA | Cure |
[29] | 38 yr./F | Hydrocephalus | O. xanthineolytica (CSF) | Meningitis | VP shunt (7 yr)/yes | PEN, PEN+RIF | Yes | Cure |
[30] | 70 yr./M | CRF, CAPD | O. xanthineolytica (peritoneal fluid, PC tip) | Peritonitis | PC (11 yr)/yes | VAN+GEN | Yes | Cure |
[31] | 23 yr./M | AIDS | O. turbata (subcutaneous fluid) | Soft tissue infection | None | Debridement | NA | Cure |
[5] | 53 yr./F | Arthropathy, intramuscular injections | O. xanthineolytica (subcutaneous fluid) | Soft tissue infection | None | DOX | NA | Cure |
[5] | 72 yr./M | None | O. xanthineolytica (bile) | Cholecystitis | None | CFX Cholecystectomy | NA | Cure |
[32] | 59 yr./F | CRF, CAPD, DM | O. xanthineolytica (peritoneal fluid) | Peritonitis | PC (6 wk)/no | VAN (ip) + TOB, DOX | No | Cure |
[33] | 28 yr./F | None | O. xanthineolytica (cornea) | Keratitis | Contact lens (NR)/yes | CFZ (drops) + GEN (drops) | NA | Cure |
[34] | 72 yr./M | Gonarthrosis, knee prosthesis, closed knee injury, alcoholism | O. xanthineolytica (sinovial tissue, bone) | Prosthetic joint infection | Prosthetic joint (3 yr)/yes | VAN, SXT Two-stage reimplantation | NA | Cure |
[35] | 13 yr./F | CRF, CAPD | O. xanthineolytica (peritoneal fluid) | Peritonitis | PC (11 mo)/no | VAN (ip) | No | Cure |
[36] | 23 mo/F | None | O. xanthineolytica (intervertebral biopsy) | Spondylodiscitis | None | CFT + RIF, CXM + RIF | NA | Cure |
[37] | 48 yr./M | HIV | C. cellulans (ulcer) | Tongue ulcer | None | PEN+AZI | NA | Cure |
[38] | 44 yr./M | Hydrocephalus | O. xanthineolytica (CSF, VP shunt) | Meningitis | VP shunt (3 mo)/yes | VAN+RIF | Yes | Cure |
[39] | 76 yr./M | COPD | O. turbata (bile) | Cholecystitis | None | Cholecystectomy | NA | Cure |
[40] | 5 yr./M | Penetrating hand injury | C. cellulans (tendon, deep biopsy) | Tenosynovitis | Splinters (4 mo)/yes | SXT + RIF Debridement | NA | Cure |
[41] | 1 d/M | Premature | O. xanthineolytica (lung) | Pneumonia | None | CTX + GEN | NA | Death |
[42] | 72 yr./F | Cataract surgery | C. cellulans (vitreous humor) | Endophthalmitis | Intraocular lens (1 d)/no | VAN (iv) + CAZ (iv) | No | Cure |
[42] | 74 yr./M | Cataract surgery, arteriosclerosis | C. cellulans (vitreous humor) | Endophthalmitis | Intraocular lens (3 d)/no | VAN (iv) + CAZ (iv) | No | Cure |
[42] | 78 yr./F | Cataract surgery | C. cellulans (vitreous humor) | Endophthalmitis | Intraocular lens (7 d)/no | VAN (iv) + CAZ (iv) Vitrectomy | No | Cure |
[43] | 28 yr./M | Penetrating eye injury | C. cellulans (vitreous humor) | Endophthalmitis | Intraocular metallic object (2 d)/yes | VAN+CAZ + CLI, VAN+CAZ + MOX (all iv) Vitrectomy | Yes | Cure |
[44] | 45 yr./M | None | C. cellulans (vitreous humor) | Endophthalmitis | None | CIP, VAN (iv) + CAZ (iv) Vitrectomy | NA | Cure |
[45] | 62 yr./M | CRF, CAPD | O. turbata (peritoneal fluid) | Peritonitis | PC (3 yr)/yes | VAN (ip) + GEN (ip) + CIP, VAN (ip) + SXT, VAN (ip) + GEN (ip) + SXT, VAN (ip) | Yes | Cure |
[46] | 81 yr./M | CRF, penetrating knee injury | C. cellulans (sinovial fluid) | Arthritis | None | LEV, LEV+LNZ, LNZ + RIF Debridement | NA | Cure |
[47] | 50 yr./F | CRF, CAPD, DM | C. cellulans (peritoneal fluid, PC tip) | Peritonitis | PC (15 mo)/yes | CAZ (ip) + TOB (ip), CAZ (ip) + TOB (ip) + VAN (ip), VAN | Yes | Cure |