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Table 1 Reported cases of Cellulosimicrobium species (or Oerskovia) infections

From: Infections due to Cellulosimicrobium species: case report and literature review

Ref Age/sex Predisposing condition or underlying disease Species (specimen) Type of infection Foreign body (time before)/ removal Antibiotic therapya and surgery Failed antibiotic therapy aloneb Outcome
[9] 68 yr./M Aortic insufficiency, prosthetic valve, Crohn’s, ankylosing spondylitis, steroids O. turbata (blood, prosthetic heart valve) Endocarditis Prosthetic heart valve (2 mo)/yes PEN, AMP + ERY, SXT, SXT + AMP, SXT + AMX Aortic valve replacement Yes Cure
[10] 3 yr./M Acute myelogenous leukemia, neutropenia O. turbata (blood) CVC-related bacteremia CVC (1 mo)/yes AMK Yes Cure
[11] 40 yr./F Crohn’s, short bowel syndrome Oerskovia species (blood, TPN solution) CVC-related bacteremia CVC (9 mo)/no VAN+GEN + MET, VAN No Cure
[12] 40 yr./M Alcoholism, cirrhosis O. xanthineolytica (blood) Bacteremia None VAN+GEN + CLI NA Cure
[13] 54 yr./F Metastatic breast cancer, chemotherapy O. xanthineolytica (blood) CVC-related? bacteremia CVC (4 mo) (unclear role)/no CXM, VAN No Cure
[14] 49 yr./F Metastatic colonic cancer O. xanthineolytica (blood, CVC tip) CVC-related bacteremia CVC (15 mo)/no VAN No Cure
[15] 27 yr./M AIDS, neutropenia O. turbata (blood) CVC-related bacteremia CVC (4 wk)/yes IMP+AMK NA Cure
[16] 53 yr./F Non-Hodgkin’s lymphoma, BMT, neutropenia O. xanthineolytica (blood, CVC tip) CVC-related bacteremia ➔Endocarditis CVC (1 yr)/yes DOX, CLI, MPM, AMX + SXT, IMP+AMK, CLA + RIF, PEN NA Death
[17] 64 yr./F Peritonitis carcinomatosa O. xanthineolytica (blood) Bacteremia None PTZ, PTZ + NET, VAN+NET, PTZ + NET NA Cure
[18] 31 yr./M CRF, renal transplant, DM O. xanthineolytica (blood, heart valve) CVC-related bacteremia ➔Endocarditis CVC (NR)/yes AMS, AMS + VAN, CAZ + VAN, VAN Aortic valve replacement NA Cure
[19] 13 yr./M Short bowel syndrome C. cellulans (blood) CVC-related bacteremia CVC (NR)/no VAN+CTX, VAN+GEN, VAN, VAN+RIF No Cure
[20] 1 d/M None C. cellulans (blood) Bacteremia None CTX + AMP, VAN NA Cure
[21] 81 yr./M Aortic stenosis, prosthetic valve C. funkei (blood) Endocarditis Prosthetic heart valve (7 mo)/no AMC, VAN+GEN Yes Death
[22] 59 yr./M COPD, arteriosclerosis C. cellulans (blood) CVC-related bacteremia CVC (7 d)/yes VAN+PTZ NA Death
[23] 80 yr./F CRF, hemodialysis C. cellulans (blood) CVC-related bacteremia CVC (NR)/yes VAN Yes Curec
[24] 59 yr./F Metastatic rectal cancer C. cellulans (blood) CVC-related bacteremia CVC (NR)/yes VAN, VAN+IMP, VAN Yes Cure
[25] 44 yr./F T-cell lymphoma, BMT, neutropenia Cellulosimicrobium species (blood, CVC tip) CVC-related bacteremia CVC (5 wk)/yes VAN+CPM, VAN+MPM, VAN NA Death
[26] ≈50 yr./M DM Oerskovia species (blood) Osteomyelitis None VAN+CPM + MET, SXT Amputation NA Cure
[27] 47 yr./F Kidney trouble? Oerskovia species (kidney) Pyonephrosis None Nephrectomy NA Cure
[28] 47 yr./M Penetrating eye injury, steroids O. xanthineolytica (vitreous humor) Endophthalmitis Intraocular metallic object (12 d)/yes GEN (sc), PEN, PEN+CFL Vitrectomy NA Cure
[29] 38 yr./F Hydrocephalus O. xanthineolytica (CSF) Meningitis VP shunt (7 yr)/yes PEN, PEN+RIF Yes Cure
[30] 70 yr./M CRF, CAPD O. xanthineolytica (peritoneal fluid, PC tip) Peritonitis PC (11 yr)/yes VAN+GEN Yes Cure
[31] 23 yr./M AIDS O. turbata (subcutaneous fluid) Soft tissue infection None Debridement NA Cure
[5] 53 yr./F Arthropathy, intramuscular injections O. xanthineolytica (subcutaneous fluid) Soft tissue infection None DOX NA Cure
[5] 72 yr./M None O. xanthineolytica (bile) Cholecystitis None CFX Cholecystectomy NA Cure
[32] 59 yr./F CRF, CAPD, DM O. xanthineolytica (peritoneal fluid) Peritonitis PC (6 wk)/no VAN (ip) + TOB, DOX No Cure
[33] 28 yr./F None O. xanthineolytica (cornea) Keratitis Contact lens (NR)/yes CFZ (drops) + GEN (drops) NA Cure
[34] 72 yr./M Gonarthrosis, knee prosthesis, closed knee injury, alcoholism O. xanthineolytica (sinovial tissue, bone) Prosthetic joint infection Prosthetic joint (3 yr)/yes VAN, SXT Two-stage reimplantation NA Cure
[35] 13 yr./F CRF, CAPD O. xanthineolytica (peritoneal fluid) Peritonitis PC (11 mo)/no VAN (ip) No Cure
[36] 23 mo/F None O. xanthineolytica (intervertebral biopsy) Spondylodiscitis None CFT + RIF, CXM + RIF NA Cure
[37] 48 yr./M HIV C. cellulans (ulcer) Tongue ulcer None PEN+AZI NA Cure
[38] 44 yr./M Hydrocephalus O. xanthineolytica (CSF, VP shunt) Meningitis VP shunt (3 mo)/yes VAN+RIF Yes Cure
[39] 76 yr./M COPD O. turbata (bile) Cholecystitis None Cholecystectomy NA Cure
[40] 5 yr./M Penetrating hand injury C. cellulans (tendon, deep biopsy) Tenosynovitis Splinters (4 mo)/yes SXT + RIF Debridement NA Cure
[41] 1 d/M Premature O. xanthineolytica (lung) Pneumonia None CTX + GEN NA Death
[42] 72 yr./F Cataract surgery C. cellulans (vitreous humor) Endophthalmitis Intraocular lens (1 d)/no VAN (iv) + CAZ (iv) No Cure
[42] 74 yr./M Cataract surgery, arteriosclerosis C. cellulans (vitreous humor) Endophthalmitis Intraocular lens (3 d)/no VAN (iv) + CAZ (iv) No Cure
[42] 78 yr./F Cataract surgery C. cellulans (vitreous humor) Endophthalmitis Intraocular lens (7 d)/no VAN (iv) + CAZ (iv) Vitrectomy No Cure
[43] 28 yr./M Penetrating eye injury C. cellulans (vitreous humor) Endophthalmitis Intraocular metallic object (2 d)/yes VAN+CAZ + CLI, VAN+CAZ + MOX (all iv) Vitrectomy Yes Cure
[44] 45 yr./M None C. cellulans (vitreous humor) Endophthalmitis None CIP, VAN (iv) + CAZ (iv) Vitrectomy NA Cure
[45] 62 yr./M CRF, CAPD O. turbata (peritoneal fluid) Peritonitis PC (3 yr)/yes VAN (ip) + GEN (ip) + CIP, VAN (ip) + SXT, VAN (ip) + GEN (ip) + SXT, VAN (ip) Yes Cure
[46] 81 yr./M CRF, penetrating knee injury C. cellulans (sinovial fluid) Arthritis None LEV, LEV+LNZ, LNZ + RIF Debridement NA Cure
[47] 50 yr./F CRF, CAPD, DM C. cellulans (peritoneal fluid, PC tip) Peritonitis PC (15 mo)/yes CAZ (ip) + TOB (ip), CAZ (ip) + TOB (ip) + VAN (ip), VAN Yes Cure
  1. AIDS Acquired immunodeficiency síndrome, AMC Amoxicillin-clavulanate, AMK Amikacin, AMP Ampicillin, AMS Ampicilllin-sulbactam, AMX Amoxicillin, AZI Azithromycin, BMT Bone marrow transplant, CAPD Chronic ambulatory peritoneal dialysis, CAZ Ceftazidime, CFL Cephalexin, CFT Ceftriaxone, CFX Cefoxitin, CFZ Cefazolin, CIP Ciprofloxacin, CLA Clarithromycin, CLI Clindamycin, COPD Chronic obstructive pulmonary disease, CPM Cefepime, CRF Chronic renal failure, CSF Cerebrospinal fluid, CTX Cefotaxime, CVC Central venous catheter, CXM Cefuroxime, DM Diabetes mellitus, DOX Doxycycline, ERY Erythromycin, GEN Gentamycin, HIV Human immunodeficiency virus, IMP Imipenem, ip Intraperitoneal, iv Intravitreal, LEV Levofloxacin, LNZ Linezolid, MET Metronidazole, MOX Moxifloxacin, MPM Meropenem, NA Not applicable, NR Not reported, NET Netilmicin, PC Peritoneal catheter, PEN Penicillin, PR Present report, PTZ Piperacillin-tazobactam, RIF Rifampin, sc Subconjunctival, SXT Trimetroprim-sulfamethoxazole, TOB Tobramycin, TPN Total parenteral nutrition, VAN Vancomycin, VP Ventriculoperitoneal
  2. aThe route of administration is systemic if it is not specified
  3. bThat is, foreign body associated infections which were not cured by antibiotic therapy alone (10 cases requiring its removal and another case resulting in death)
  4. cLater death not attributable to the infection