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Table 4 Performance of pill count adherence in determining viral load suppression

From: Long-term adherence to antiretroviral therapy in a South African adult patient cohort: a retrospective study

Pill count adherence

Viral load unsuppressed (≥400 copies/ml)

Viral load suppressed (< 400 copies/ml)

Sensitivity (95% CI)

Specificity (95% CI)

PPV (95% CI)

NPV (95% CI)

Year 1 on ART (n = 268)

 < 95%

2 (1%)

9 (3%)

97% (94–98)

22% (3–60)

97% (94–99)

18% (2–52)

 ≥ 95%

7 (3%)

250 (93%)

Year 2 on ART (n = 201)

 < 95%

1 (1%)

4 (2%)

98% (95–99)

10% (0–45)

95% (91–98)

20% (1–72)

 ≥ 95%

9 (4%)

187 (93%)

Year 3 on ART (n = 166)

 < 95%

3 (2%)

4 (2%)

97% (94–99)

33% (7–70)

96% (92–99)

43% (10–82)

 ≥ 95%

6 (4%)

153 (92%)

Year 4 on ART (n = 243)

  < 95%

0

4 (2%)

98% (96–100)

0

95% (91–97)

0

  ≥ 95%

13 (5%)

226 (93%)

Year 5 on ART (n = 233)

 < 95%

1 (1%)

11 (5%)

95% (91–98)

9% (0–41)

95% (92–98)

8% (0–38)

 ≥ 95%

10 (4%)

211 (90%)

  1. CI Confidence interval
  2. ART Antiretroviral therapy
  3. PPV Positive predictive value
  4. NPV Negative predictive value
  5. n Number of patients