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Table 2 Summary estimates of the diagnostic accuracy of presepsin, C-reactive protein, procalcitonin to diagnose pediatric sepsis

From: Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis

Author(s) and year Sensitivity (95% CI) Specificity (95% CI) Positive LR (95% CI) Negative LR (95% CI) DOR (95% CI)
Presepsin
 Plesko 2016–1 0.81 [0.54, 0.94] 0.28 [0.17, 0.43] 1.13 [0.82, 1.56] 0.68 [0.20, 2.27] 1.67 [0.36, 7.67]
 Plesko 2016–2 0.82 [0.56, 0.94] 0.57 [0.42, 0.71] 1.91 [1.25, 2.91] 0.31 [0.10, 0.99] 6.09 [1.37, 27.17]
 Tanir Basaranoglu 2017 0.99 [0.92, 1.00] 0.93 [0.86, 0.97] 14.60 [6.51, 32.73] 0.01 [0.001, 0.14] 1606.09 [87.05, 29,633.96]
 Baraka 2018 0.97 [0.79, 1.00] 0.85 [0.71, 0.93] 6.44 [3.16, 13.13] 0.03 [0.002, 0.48] 207.77 [11.09, 3892.29]
 Bivariate summary estimates (95% CI) 0.94 [0.74, 0.99] 0.71 [0.35, 0.92] 3.24 [1.14, 12.38] 0.08 [0.01, 0.74] 32.87 [2.12, 510.09]
CRP
 Plesko 2016–1 0.28 [0.14, 0.49] 0.95 [0.85, 0.98] 5.43 [1.38, 21.38] 0.76 [0.58, 0.99] 7.17 [1.50, 34.24]
 Plesko 2016–2 0.50 [0.29, 0.72] 0.71 [0.58, 0.82] 1.74 [0.92, 3.29] 0.70 [0.42, 1.16] 2.48 [0.81, 7.60]
 Baraka 2018 0.76 [0.54, 0.90] 0.66 [0.51, 0.79] 2.26 [1.39, 3.69] 0.36 [0.16, 0.82] 6.33 [1.85, 21.72]
 Bivariate summary estimates (95% CI) 0.51 [0.24, 0.78] 0.81 [0.53, 0.94] 2.68 [0.51, 13.00] 0.60 [0.23, 1.43] 4.63 [2.16, 9.95]
PCT
 Plesko 2016–1 0.80 [0.59, 0.91] 0.68 [0.53, 0.80] 2.47 [1.54, 3.97] 0.30 [0.13, 0.71] 8.18 [2.44, 27.43]
 Plesko 2016–2 0.66 [0.42, 0.84] 0.79 [0.67, 0.88] 3.19 [1.67, 6.08] 0.43 [0.22, 0.86] 7.36 [2.14, 25.32]
 Baraka 2018 0.97 [0.79, 1.00] 0.80 [0.66, 0.89] 4.93 [2.69, 9.04] 0.03 [0.002, 0.51] 150.18 [8.20, 2750.01]
 Bivariate summary estimates (95% CI) 0.76 [0.59, 0.88] 0.76 [0.67, 0.83] 3.17 [1.79, 5.18] 0.32 [0.61, 0.14] 11.88 [3.49, 40.47]
 Bivariate summary estimates (95% CI) (Total) 0.79 [0.60, 0.90] 0.75 [0.61, 0.86] 3.16 [1.54, 6.43] 0.28 [0.66, 0.12] 10.76 [4.31, 26.83]
  1. CRP C-reactive protein, PCT procalcitonin, CI confidence interval, LR likelihood ratio, DOR diagnostic odds ratio