Skip to main content

Table 2 Summary estimates of the diagnostic accuracy of presepsin, C-reactive protein, procalcitonin to diagnose pediatric sepsis

From: Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis

Author(s) and year

Sensitivity (95% CI)

Specificity (95% CI)

Positive LR (95% CI)

Negative LR (95% CI)

DOR (95% CI)

Presepsin

 Plesko 2016–1

0.81 [0.54, 0.94]

0.28 [0.17, 0.43]

1.13 [0.82, 1.56]

0.68 [0.20, 2.27]

1.67 [0.36, 7.67]

 Plesko 2016–2

0.82 [0.56, 0.94]

0.57 [0.42, 0.71]

1.91 [1.25, 2.91]

0.31 [0.10, 0.99]

6.09 [1.37, 27.17]

 Tanir Basaranoglu 2017

0.99 [0.92, 1.00]

0.93 [0.86, 0.97]

14.60 [6.51, 32.73]

0.01 [0.001, 0.14]

1606.09 [87.05, 29,633.96]

 Baraka 2018

0.97 [0.79, 1.00]

0.85 [0.71, 0.93]

6.44 [3.16, 13.13]

0.03 [0.002, 0.48]

207.77 [11.09, 3892.29]

 Bivariate summary estimates (95% CI)

0.94 [0.74, 0.99]

0.71 [0.35, 0.92]

3.24 [1.14, 12.38]

0.08 [0.01, 0.74]

32.87 [2.12, 510.09]

CRP

 Plesko 2016–1

0.28 [0.14, 0.49]

0.95 [0.85, 0.98]

5.43 [1.38, 21.38]

0.76 [0.58, 0.99]

7.17 [1.50, 34.24]

 Plesko 2016–2

0.50 [0.29, 0.72]

0.71 [0.58, 0.82]

1.74 [0.92, 3.29]

0.70 [0.42, 1.16]

2.48 [0.81, 7.60]

 Baraka 2018

0.76 [0.54, 0.90]

0.66 [0.51, 0.79]

2.26 [1.39, 3.69]

0.36 [0.16, 0.82]

6.33 [1.85, 21.72]

 Bivariate summary estimates (95% CI)

0.51 [0.24, 0.78]

0.81 [0.53, 0.94]

2.68 [0.51, 13.00]

0.60 [0.23, 1.43]

4.63 [2.16, 9.95]

PCT

 Plesko 2016–1

0.80 [0.59, 0.91]

0.68 [0.53, 0.80]

2.47 [1.54, 3.97]

0.30 [0.13, 0.71]

8.18 [2.44, 27.43]

 Plesko 2016–2

0.66 [0.42, 0.84]

0.79 [0.67, 0.88]

3.19 [1.67, 6.08]

0.43 [0.22, 0.86]

7.36 [2.14, 25.32]

 Baraka 2018

0.97 [0.79, 1.00]

0.80 [0.66, 0.89]

4.93 [2.69, 9.04]

0.03 [0.002, 0.51]

150.18 [8.20, 2750.01]

 Bivariate summary estimates (95% CI)

0.76 [0.59, 0.88]

0.76 [0.67, 0.83]

3.17 [1.79, 5.18]

0.32 [0.61, 0.14]

11.88 [3.49, 40.47]

 Bivariate summary estimates (95% CI) (Total)

0.79 [0.60, 0.90]

0.75 [0.61, 0.86]

3.16 [1.54, 6.43]

0.28 [0.66, 0.12]

10.76 [4.31, 26.83]

  1. CRP C-reactive protein, PCT procalcitonin, CI confidence interval, LR likelihood ratio, DOR diagnostic odds ratio