Persistence of cervical high-risk human papillomavirus in women living with HIV in Denmark – the SHADE

BMC Infectious Diseases

Table 4 Worse cytological and histological findings in women living with HIV with persistent^a and cleared^b high-risk (hr) human papillomavirus (HPV) infection during the study period 2011–2014 (n = 71)

	HPV persistence (n = 31)	HPV clearance (n = 40)
Cytology
Normal cytology, n(%)	16 (36.4)	28 (63.6)
ASCUS^c, n(%)	0 (0)	1 (100.0)
LSIL^d, n(%)	9 (50.0)	9 (50.0)
HSIL^e, n(%)	6 (75.0)	2 (25.0)
Carcinoma, n(%)	0 (0)	0 (0)
Histology
Normal histology, n(%)	3 (30.0)	7 (70.0)
CIN1^f, n(%)	4 (66.7)	2 (33.3)
CIN2^g, n(%)	3 (75.0)	1 (25.0)
CIN3^h, n(%)	2 (100.0)	0 (0)
Carcinoma verified histologically, n(%)	0 (0)	0 (0)

^aPersistent = Type-specific persistence was defined as positivity of the same hrHPV type in two separate cervical samples having been taken at least 1 year and at most 2 years after the date the patient was first hrHPV positive; ^bCleared = having one or more negative results after an hrHPV positive sample; ^cASCUS atypical cells of undetermined significance; ^dLSIL = low-grade squamous intraepithelial lesions; ^eHSIL high-grade squamous intraepithelial lesions including atypical squamous cells - cannot exclude HSIL (ASC-H), atypical glandular cells (AGC) and adenocarcinoma in situ (AIS); ^fCIN1 cervical intraepithelial neoplasia grade 1; ^gCIN2 cervical intraepithelial neoplasia grade 2; ^hCIN3 cervical intraepithelial neoplasia grade 3

ISSN: 1471-2334