Skip to main content

Advertisement

Table 3 Receiver operating characteristic curve analyses for IL-23, IL-27, IFN-γ, and ADA in differentiating TMPE from TPE

From: Comparison of pleural effusion features and biomarkers between talaromycosis and tuberculosis in non-human immunodeficiency virus-infected patients

Biomarker Optimal cutoff Sensitivity (%) (95% CI) Specificity (%) (95% CI) LR (+) LR (−) AUC (95% CI) p-value
IL-23 > 53.07 pg/mL 100 (54.1–100) 88.89 (51.7–99.7) 9 1.12 0.875 (0.688–1.000) 0.001 a
IL-27 < 35.75 pg/mL 100 (59.0–100) 66.7 (22.3–95.7) 3 0.85 0.762 (0.463–1.000) 0.116
ADA < 10.9 U/L 100 (63.1–100) 87.5 (47.4–99.7) 8 1.14 0.953 (.0850–1.000) 0.002 a
IFN-γ < 129.9 pg/mL 100 (59.0–100) 83.33 (22.3–95.7) 6 1.2 0.952 (0.839–1.000) 0.006 a
  1. ADA Adenosine deaminase, TMPE Talaromyces marneffei pleural effusions, ADA Adenosine deaminase, AUC Area under the curve, CI Confidence interval, IFN Interferon, IL Interleukin, LR Likelihood ratio, TPE Tuberculous pleural effusion
  2. a p < 0.05