Fig. 1

Immune phenotypes and HIV-specific T cell responses prior to and following ART imitation in the setting of EC. CD4+ and CD8+ T cell immune phenotyping prior to and following initiation of antiretroviral therapy. Changes in CD4+ T cell subsets, markers of early and late activation, and PD-1 and CCR5 expression are shown in a-c. Changes in frequencies of CD8+ T cells expressing subset, activation, immune checkpoint, and CCR5 are shown in d-f. Frequencies of cells co-expressing CD107a and Interferon (IFN) γ (g) and Tumor Necrosis Factor (TNF) α and Interferon (IFN) γ (h) are shown prior to and following initiation of ART. Results shown in all panels are from sampling at least 2 years following acute HIV infection