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Table 3 Predictors of Mortality Among HIV-infected and HIV-uninfected Patients in Durban, South Africa

From: Assessing rates and contextual predictors of 5-year mortality among HIV-infected and HIV-uninfected individuals following HIV testing in Durban, South Africa

Measure Primary analysis Alternate analyses
PS & CD4 MI HR (95% CI) P ǂ CD4 MI HR (95% CI) PS HR (95% CI) Base HR (95% CI)
a. Adjusted hazard ratio of factors in the primary and alternative multivariable models, and in univariate analyses
 HIV Statusx 3.86 (3.08–4.85) < 0.001 3.99 (2.94–5.41) 4.44 (3.51–5.62) 4.54 (3.32–6.21)
 Male sex 1.57 (1.35–1.82) < 0.001 1.67 (1.35–2.06) 1.67 (1.44–1.93) 1.75 (1.41–2.16)
 Test received at primary health clinic 0.51 (0.38–0.68) < 0.001 0.60 (0.40–0.91) 0.47 (0.35–0.62) 0.55 (0.37–0.83)
 Healthcare use in past year:
  1–2 times 1.53 (1.15–2.02) 0.003 1.66 (1.09–2.54) 1.65 (1.25–2.18) 1.79 (1.17–2.73)
  3–5 times 1.86 (1.41–2.44) < 0.001 1.99 (1.32–3.00) 2.01 (1.54–2.63) 2.16 (1.44–3.25)
   > 5 times 2.34 (1.75–3.12) < 0.001 2.39 (1.55–3.67) 2.63 (1.98–3.49) 2.68 (1.75–4.10)
 Total number of healthcare barrier domains reported out of 5 possible 1.12 (1.07–1.16) < 0.001 1.11 (1.05–1.18) 1.14 (1.09–1.18) 1.13 (1.06–1.20)
 10-point increase in mental health score corresponding to better mental health 0.93 (0.89–0.97) 0.002 0.94 (0.89–1.01) 0.92 (0.88–0.96) 0.94 (0.88–1.00)
 CD4 count (per 100) 0.80 (0.76–0.84) < 0.001 0.82 (0.76–0.88)
b. Adjusted hazard ratios related to the interaction between age and HIV status
 10-year age increase for HIV-infected* 1.22 (1.13–1.31) < 0.001 1.20 (1.07–1.35) 1.24 (1.15–1.34) 1.21 (1.08–1.36)
 10-year age increase for HIV-uninfected* 1.94 (1.78–2.11) < 0.001 1.89 (1.69–2.11) 1.92 (1.77–2.09) 1.87 (1.67–2.09)
 HR for HIV-infected at age 20 6.59 (4.79–9.06) < 0.001 6.98 (4.43–11.00) 7.11 (5.07–9.96) 7.24 (4.61–11.38)
 HR for HIV-infected at age 30 4.24 (3.35–5.35) < 0.001 4.45 (3.18–6.22) 4.59 (3.58–5.89) 4.71 (3.38–6.56)
 HR for HIV-infected at age 40 2.72 (2.26–3.28) < 0.001 2.83 (2.18–3.67) 2.96 (2.46–3.57) 3.06 (2.38–3.94)
 HR for HIV-infected at age 50 1.75 (1.43–2.15) < 0.001 1.80 (1.38–2.36) 1.91 (1.60–2.29) 1.99 (1.54–2.57)
 HR for HIV-infected at age 60 1.13 (0.86–1.48) < 0.001 1.15 (0.81–1.63) 1.24 (0.98–1.56) 1.29 (0.92–1.82)
  1. PS: with propensity score adjustment; CD4 MI: with CD4 multiple imputation; HR: adjusted hazard ratio; Base: baseline analysis without propensity score adjustment or CD4 multiple imputation.
  2. x The HIV status variable is calculated as a contrast based on the parameter estimates for the HIV factor,and age factor, incorporating the average difference in age between the HIV+ and HIV- groups. For models including CD4, the HIV status variable also adjusts for the parameter estimate for CD4 and the and the average difference in CD4 between the HIV+ and HIV- groups
  3. ǂ p-values were generated from Cox proportional hazards models