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Table 1 The clinical profile, details of hospitalization, outcome of patients and molecular characterization of LRCoNS

From: Linezolid resistant coagulase negative staphylococci (LRCoNS) with novel mutations causing blood stream infections (BSI) in India

S. NO. aAGE GROUP/SEX WARD HISTORY/DIAGNOSIS DEVICE SPECIES MIC (μg/ml) Resistance pattern Mechanism of Resistance
LZ VA   cfr gene 23S rRNA Mutation
1b 1–5 /F Paediatric Congenital Cystic Adenomatoid Malformation & Respiratory Failure ICD, PC S. arlettae 8 2 CN, E, CD, G, CIP, COT POS G2614 T
2 < 1/F Paediatric VSD, Hepatomegaly, Pneumonia PC S. arlettae 16 2 CN, E, CD, CIP, COT POS G2614 T C2384T
3 21–40/M ICU Hepatic abscess V, PC S.haemolyticus 8 2 CN, E, CD, G, CIP, CH, COT POS G2614 T
4b 21–40/M ICU Perforation Peritonitis With Septic Shock V, PC S.haemolyticus 32 4 CN, E, CD, G, CIP, CH, COT POS G2614 T
5b 41–60/M Medicine Diabetes MellitusChronic alcoholic with hepatitis PC S.cohnii 32 2 CN, E, CD, G, CIP, CH,COT POS NIL
6 1–5 /F Paediatric Pneumonia PC S.haemolyticus 32 4 CN, E, CD, G, CIP, CH,COT, TC POS G2614 T
7 21–40/M ICU fracture OF Inferior pelvic remi, acetabulam,ileum, hemo-peritoneum, Pleural effusion V, PC S.haemolyticus 32 4 CN,E,CD, G, CIP, CH,COT, TC POS G2614 T
8 21–40/F ICU Pulmonary edema With Amniotic Fluid Embolism With ARF V, PC S.cohnii 8 1 CN,E,CD, G, CIP, CH, COT, TC POS C2384T
9 21–40/F Respiratory medicine Pneumonia PC S.haemolyticus 32 2 CN,E,CD, G, CIP, CH, COT, TC POS G2614 T
10 61–80/F ICU Closed traumatic fracture neck femur, DVT, Pulmonary Embolism V, PC S.haemolyticus 16 2 CN,E,CD, G, CIP, CH, COT, TC POS G2614 T
11 11–20/M ICU Opium Poisoning V, PC S.haemolyticus 32 2 CN,E,CD, G, CIP, CH, COT, TC POS G2614 T
12 41–60/F Oncology Carcinoma Ovary With Metastasis PC S.haemolyticus 32 2 CN,E,CD, G, CIP, CH, COT, TC POS G2614 T
13 21–40/F Obstetrics Preterm Baby With PROM PC S.haemolyticus 8 1 CN, E, CD, G, COT, TC POS G2614 T
14 41–60/F ICU Head Injury With GCS Score 2 V, PC S.arlettae 8 2 CN,E,CD, G, CIP, CH, COT, TC POS NIL
15 11–20/F ICU Snake bite V, PC S.cohnii 8 2 CN,E,CD, G, CIP, CH, COT, TC POS NIL
  1. a Age group in Years < 1, < 5, 5–10, 11–20,21-40,41-60,61–80,> 80
  2. b patient expired, M Male, F Female, VSD Ventricular septal defect, ARF Acute renal failure, DVT Deep vein thrombosis, PROM Premature rupture of membrane, GCS Glasgow coma score, V Ventilator, PC Peripheral catheter, ICD Intercostal drain, POS Positive, LZ Linezolid, VA Vancomycin, CN Cefoxitin, E Erytromycin, CD Clindamycin, G Gentamicin, CIP Ciprofloxacin, CH Chloramphenicol, COT Trimethoprim-sulfamethoxazole, TC Teicoplanin
  3. GenBank Accession numbers of the 23 s rRNA gene sequence of the isolates in which mutation was observed are KY952716, KY952715, KY952717, KY952718, KY952719, KY952720, KY952714, KY952721, KY952722, KY952723, KY952724 and KY952725 in order of the serial number in the table