Linezolid resistant coagulase negative staphylococci (LRCoNS) with novel mutations causing blood stream infections (BSI) in India

Mittal, Gajanand; Bhandari, Vasundhra; Gaind, Rajni; Rani, Vandana; Chopra, Shimpi; Dawar, Reetika; Sardana, Raman; Verma, P. K.

doi:10.1186/s12879-019-4368-6

Table 1 The clinical profile, details of hospitalization, outcome of patients and molecular characterization of LRCoNS

From: Linezolid resistant coagulase negative staphylococci (LRCoNS) with novel mutations causing blood stream infections (BSI) in India

S. NO.	^aAGE GROUP/SEX	WARD	HISTORY/DIAGNOSIS	DEVICE	SPECIES	MIC (μg/ml)		Resistance pattern	Mechanism of Resistance
S. NO.	^aAGE GROUP/SEX	WARD	HISTORY/DIAGNOSIS	DEVICE	SPECIES	LZ	VA		cfr gene	23S rRNA Mutation
1^b	1–5 /F	Paediatric	Congenital Cystic Adenomatoid Malformation & Respiratory Failure	ICD, PC	S. arlettae	8	2	CN, E, CD, G, CIP, COT	POS	G2614 T
2	< 1/F	Paediatric	VSD, Hepatomegaly, Pneumonia	PC	S. arlettae	16	2	CN, E, CD, CIP, COT	POS	G2614 T C2384T
3	21–40/M	ICU	Hepatic abscess	V, PC	S.haemolyticus	8	2	CN, E, CD, G, CIP, CH, COT	POS	G2614 T
4^b	21–40/M	ICU	Perforation Peritonitis With Septic Shock	V, PC	S.haemolyticus	32	4	CN, E, CD, G, CIP, CH, COT	POS	G2614 T
5^b	41–60/M	Medicine	Diabetes MellitusChronic alcoholic with hepatitis	PC	S.cohnii	32	2	CN, E, CD, G, CIP, CH,COT	POS	NIL
6	1–5 /F	Paediatric	Pneumonia	PC	S.haemolyticus	32	4	CN, E, CD, G, CIP, CH,COT, TC	POS	G2614 T
7	21–40/M	ICU	fracture OF Inferior pelvic remi, acetabulam,ileum, hemo-peritoneum, Pleural effusion	V, PC	S.haemolyticus	32	4	CN,E,CD, G, CIP, CH,COT, TC	POS	G2614 T
8	21–40/F	ICU	Pulmonary edema With Amniotic Fluid Embolism With ARF	V, PC	S.cohnii	8	1	CN,E,CD, G, CIP, CH, COT, TC	POS	C2384T
9	21–40/F	Respiratory medicine	Pneumonia	PC	S.haemolyticus	32	2	CN,E,CD, G, CIP, CH, COT, TC	POS	G2614 T
10	61–80/F	ICU	Closed traumatic fracture neck femur, DVT, Pulmonary Embolism	V, PC	S.haemolyticus	16	2	CN,E,CD, G, CIP, CH, COT, TC	POS	G2614 T
11	11–20/M	ICU	Opium Poisoning	V, PC	S.haemolyticus	32	2	CN,E,CD, G, CIP, CH, COT, TC	POS	G2614 T
12	41–60/F	Oncology	Carcinoma Ovary With Metastasis	PC	S.haemolyticus	32	2	CN,E,CD, G, CIP, CH, COT, TC	POS	G2614 T
13	21–40/F	Obstetrics	Preterm Baby With PROM	PC	S.haemolyticus	8	1	CN, E, CD, G, COT, TC	POS	G2614 T
14	41–60/F	ICU	Head Injury With GCS Score 2	V, PC	S.arlettae	8	2	CN,E,CD, G, CIP, CH, COT, TC	POS	NIL
15	11–20/F	ICU	Snake bite	V, PC	S.cohnii	8	2	CN,E,CD, G, CIP, CH, COT, TC	POS	NIL

^a Age group in Years < 1, < 5, 5–10, 11–20,21-40,41-60,61–80,> 80
^b patient expired, M Male, F Female, VSD Ventricular septal defect, ARF Acute renal failure, DVT Deep vein thrombosis, PROM Premature rupture of membrane, GCS Glasgow coma score, V Ventilator, PC Peripheral catheter, ICD Intercostal drain, POS Positive, LZ Linezolid, VA Vancomycin, CN Cefoxitin, E Erytromycin, CD Clindamycin, G Gentamicin, CIP Ciprofloxacin, CH Chloramphenicol, COT Trimethoprim-sulfamethoxazole, TC Teicoplanin
GenBank Accession numbers of the 23 s rRNA gene sequence of the isolates in which mutation was observed are KY952716, KY952715, KY952717, KY952718, KY952719, KY952720, KY952714, KY952721, KY952722, KY952723, KY952724 and KY952725 in order of the serial number in the table

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ISSN: 1471-2334

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