Table 3 Rate of Incident TB in entire cohort and subgroup analysis
Characteristics | Entire Cohort (n = 1904) | Patients with NO baseline prevalent TB (n = 1267) | ||
|---|---|---|---|---|
Number of patients (n) | Incidence rate (95% CI)per 100 person years | Number of patients (n) | Incidence rate (95% CI) per 100 person years | |
Total patients | 182 | 1.85 (1.604, 2.144) | 113 | 1.73 (1.436, 2.076) |
Age (years) | ||||
  ≤ 40 years | 100 | 1.83 (1.502, 2.223) | 63 | 1.75 (1.363, 2.233) |
  > 40 years | 82 | 1.89 (1.521, 2.344) | 50 | 1.71 (1.292, 2.249) |
Gender | ||||
 Female | 50 | 1.49 (1.132, 1.971) | 35 | 1.34 (0.961, 1.865) |
 Male | 132 | 2.04 (1.721, 2.421) | 78 | 1.98 (1.589, 2.478) |
History of prior TB at baseline | ||||
 Yes | 69 | 2.11 (1.666, 2.671) |  |  |
 No | 113 | 1.73 (1.436, 2.076) |  |  |
Haemoglobin at baseline (g/dl) | (n = 156) |  | (n = 88) |  |
  ≤ 10 | 53 | 2.84 (2.171, 3.719) | 65 | 2.79 (1.853, 4.196) |
  > 10 | 103 | 1.58 (1.304, 1.919) | 23 | 1.43 (1.125, 1.830) |
Virologic status on ART | ||||
 Virologic failure (VF) | 105 | 8.51 (7.030, 10.307) | 71 | 10.23 (8.107, 12.910) |
 Virologic suppression (VS) | 77 | 0.90 (0.717, 1.122) | 42 | 0.72 (0.530, 0.972) |
IPT | ||||
 ART plus IPT | 5 | 0.20 (0.081, 0.469) | 2 | 0.11 (0.026, 0.423) |
 ART alone | 177 | 2.44 (2.106, 2.828) | 111 | 2.38 (1.979, 2.872) |
Duration of ART (months) | ||||
  ≤ 12 | 33 | 24.32 (17.293, 34.215) | 23 | 25.58 (16.998, 38.492) |
 13–36 | 52 | 5.46 (4.162, 7.167) | 29 | 4.32 (3.005, 6.223) |
 37–60 | 44 | 2.54 (1.890, 3.413) | 28 | 2.41 (1.666, 3.495) |
  > 60 | 53 | 0.75 (0.579, 0.992) | 33 | 0.72 (0.507, 1.004) |
Pre ART CD4 count (cells/mm3) | ||||
  ≤ 50 | 32 | 2.28 (1.612, 3.224) | 18 | 2.57 (1.621, 4.085) |
 51–200 | 108 | 2.20 (1.824, 2.660) | 59 | 1.98 (1.537, 2.560) |
 201–500 | 41 | 1.28 (0.943, 1.740) | 35 | 1.35 (0.967, 1.875) |
  >  500 | 1 | 0.32 (0.045, 2.303) | 1 | 0.36 (0.052, 2.625) |
Current/ updated CD4 count (cells/mm3) | ||||
  ≤ 200 | 107 | 7.36 (6.090, 8.896) | 65 | 8.35 (6.548, 10.648) |
 201–350 | 36 | 1.75 (1.265, 2.432) | 22 | 1.64 (1.078, 2.486) |
 351–500 | 20 | 1.03 (0.667, 1.602) | 12 | 0.97 (0.552, 1.711) |
  >  500 | 19 | 0.43 (0.277, 0.681) | 14 | 0.44 (0.260, 0.741) |