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Table 1 The timeline of the P. vivax attacks for the patient and antimalarial treatment

From: Multiple relapses of Plasmodium vivax malaria acquired from West Africa and association with poor metabolizer CYP2D6 variant: a case report

  1st attack 2nd attack 3rd attack 4th attack 5th attack
Days from previous attack 0 58 113 88 232
Days from the 1st attack 0 58 171 259 491
Axillary temperature (°C) on admission 38.0 38.3 38.4 38.6 38.9
Symptomsa R, H, B, C R, H, B R, H, B R, H, B R, H, B
Parasitemia (%) on admission 0.36 0.25 0.19 0.18 0.38
Treatmentb CQ/PQ + AS (420 mg) CQ/PQ + AS (660 mg); ACT1 CQ/PQ + AS (660 mg); ACT2 CQ/PQ; ACT2 AS (660 mg) + AZ (3500 mg); ACT2
Fever clearance time (h) 16 21 18.5 NA 23
  1. aSymptoms: R – rigor, H – headache, B – body aches, C – cough
  2. bDrug treatment: CQ/PQ – chloroquine (total 1200 mg base, 600 mg on day 1, 300 mg each on day 2 and 3)/primaquine (total 180 mg, 22.5 mg daily for 8 days), AS – artesunate at 12 h interval, ACT1 – artesunate-amodiaquine, ACT2 - dihydroartemisinin-piperaquine, AZ – azithromycin, NA – not available