TY - JOUR AU - He, Xi AU - Pan, Maohua AU - Zeng, Weilin AU - Zou, Chunyan AU - Pi, Liang AU - Qin, Yucheng AU - Zhao, Luyi AU - Qin, Pien AU - Lu, Yuxin AU - Baird, J. Kevin AU - Huang, Yaming AU - Cui, Liwang AU - Yang, Zhaoqing PY - 2019 DA - 2019/08/09 TI - Multiple relapses of Plasmodium vivax malaria acquired from West Africa and association with poor metabolizer CYP2D6 variant: a case report JO - BMC Infectious Diseases SP - 704 VL - 19 IS - 1 AB - Plasmodium vivax transmission in West Africa, dominant for the Duffy-negative blood group, has been increasingly recognized from both local residents as well as international travelers who contracted P. vivax malaria there. However, the relapsing pattern and sensitivity to antimalarial treatment of P. vivax strains originated from this region are largely unknown. There is evidence that the efficacy of primaquine for radical cure of relapsing malaria depends on host factors such as the hepatic enzyme cytochrome P450 (CYP) 2D6. SN - 1471-2334 UR - https://doi.org/10.1186/s12879-019-4357-9 DO - 10.1186/s12879-019-4357-9 ID - He2019 ER -