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Table 3 Schedule of the CROPrEP project

From: Protocol for a multicenter, real-world study of HIV pre-exposure prophylaxis among men who have sex with men in China (CROPrEP)

Procedures Screening/Enrollment FU 1 m ± 7dd FU 3 m ± 7d FU 6 m ± 7d FU 9 m ± 7d FU 12 m ± 7d
Informed consent ×      
Self-administrated questionnaire × × × × × ×
Interviews
 Relevant medical history ×      
 Current/concomitant medication × × × × × ×
 Adverse events or side effects   × × × × ×
Medication return and allocation × × × × × ×
HIV/STIs testing
 HIV screening × × × × × ×
 HIV Western Blota × × × × × ×
 HIV RNA Pooling PCRb × × × × × ×
 HIV resistance testingc       
 HIV-1 viral loadc       
 Syphilis × × × × × ×
 HSV-2 × × × × × ×
Safety assessment
 Routine blood tests × × × × × ×
 Routine urine tests × × × × × ×
 Liver functions tests × × × × × ×
 Renal functions tests × × × × × ×
 Blood glucose and lipids × × × × × ×
 Bone mineral density ×    ×   ×
 Hepatitis B virus ×    ×   ×
Adherence lab assessment
 Blood drug level testing   × × × × ×
  1. Abbreviations: FU Follow-up, m Month(s), d Day, HSV-2 Herpes simplex virus 2
  2. aAnyone who screens positive for HIV will have the results confirmed by western blotting
  3. bAnyone who screens negative for HIV will have the results confirmed by HIV RNA pooling PCR test
  4. cAnyone who tests positive for HIV will have their samples further tested for HIV resistance and viral load
  5. dVisit window, 7 days