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Table 1 Demographic, clinical and laboratory parameters of TASMC cases

From: Clinical benefits of FilmArray meningitis-encephalitis PCR assay in partially-treated bacterial meningitis in Israel

  Study groupJune 2016 – June 2018 Control groupJanuary 2010 – May 2016 p-value
Number of cases 8 23  
Annual frequency (cases per year) 4 3.5  
Age (years) 40 ± 26 43 ± 20 0.73
Male, n (%) 4 (50) 7 (30) 0.57
Duration of antibiotic treatment prior to diagnosis (hours) 13 ± 18 77 ± 73 0.02
FilmArray ME PCR result N. meningitidis (n = 4), L. monocytogenes (n = 2), S. pneumoniae (n = 1),H. influenzae (n = 1) Not applicable  
Antimicrobials used in initial regimen
 Ceftriaxone 7 (88) 23 (100) 0.57
 Ampicillin 3 (38) 8 (35) 0.89
 Vancomycin 3 (38) 16 (70) 0.23
 Acyclovir 2 (25) 7 (30) 0.77
 Doxycycline 1 (13) 6 (26) 0.76
 Other 0 (0) 4a (17) 0.51
Antimicrobials used in final regimen
 Ceftriaxone 6 (75) 18 (78) 0.85
 Ampicillin 2 (25) 5 (22) 0.85
 Vancomycin 1 (13) 4 (17) 0.75
 Acyclovir 0 (0) 1 (4) 0.55
 Doxycycline 0 (0) 5 (22) 0.38
 Other 0 (0) 2b (9) 0.98
 CSF-WBC (cells/μl) 3575 ± 3393 1186 ± 1429c 0.01
 CSF-PMN-(%) 78 ± 24 d 66 ± 32c 0.38
 CSF-RBC (cells/μl) 26 ± 26 115 ± 201c 0.22
 Glucose ratio (CSF:blood) 28 ± 26 44 ± 21c 0.11
 CSF-Protein (mg/dL) 214 ± 121 183 ± 153 0.62
 CSF-gram stain positive, n (%) 2 (25), 1-GP and 1-GN cocci 1 (4), GP cocci 0.31
 Blood-WBC (10e3cells/ μl) 17 ± 8 16 ± 8 0.7
 Blood-CRP (mg/L) 153 ± 107 80 ± 86 0.06
 Chronic diseases 3 (38) 12 (52) 0.76
• Diabetes Mellitus 2 (25) 4 (17) 0.63
• Hypertension 2 (25) 4 (17) 0.63
• Vascular disease 2 (25) 1 (4) 0.16
(PVD/stroke/MI)
• Other 1e (13) 3f (13) 0.97
  1. GP gram positive, GN gram negative, CSF cerebrospinal fluid, WBC white blood cells, PMN polymorphonuclear, RBC red blood cells, CRP c-reactive protein, PVD peripheral vascular disease
  2. Bold values are significant
  3. a4 other antimicrobials used were clindamycin, oseltamivir, TMP-SMX, fluconazole
  4. b2 other antimicrobials used were meropenem and moxifloxacin
  5. cOnly 22 cases were included in the analyses of these parameters due to missing data in one case with a traumatic lumbar puncture
  6. d Only 7 cases were included in the analyses of these parameters due to missing data in files.
  7. eOne patient with metastatic neuroendocrine tumor
  8. f3 patients with HIV / Lymphoma / Multiple sclerosis