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Table 2 Frequency of nonadherence types per interval and cumulative probability of adherence to ART among a cohort of mothers (N = 1572) and NVP among a cohort of infants (N = 2370) from 6 weeks to 18 months postpartum in South Africa followed in 2012–2014 (unweighted)

From: Longitudinal adherence to maternal antiretroviral therapy and infant Nevirapine prophylaxis from 6 weeks to 18 months postpartum amongst a cohort of mothers and infants in South Africa

  Follow-up intervals from 6 weeks to 18 months postpartum
6 weeks - 14 weeks 14 weeks - 6 months 6 months - 9 months 9 months - 12 months 12 months - 15 months 15 months - 18 months
Adherence to ART among mothers reported on ART
 Total number of mothers entering interval n = 1026 n = 902 n = 866 n = 833 n = 800 n = 832
  Cumulative probability of adherencea 85.0 (82.8–87.0) 79.1 (76.6–81.4) 74.2 (71.6–76.6) 71.1 (67.0–72.2) 67.3 (64.6–69.9) 63.4 (60.7–66.0)
  Total adherence events during interval 861 820 801 777 749 763
  Total nonadherence events during interval 165 82 65 56 51 69
   Taking ART but missed > 5% doses 25 (15.2) 17 (20.7) 17 (26.2) 9 (16.1) 8 (15.7) 8 (11.6)
   Stopped taking ART during interval (not according to care) 140 (84.8) 65 (79.3) 48 (73.8) 47 (83.9) 43 (84.3) 61 (88.4)
Mothers not included in the analysis at each stage and reason for exclusion
 Total number of mothers not reporting on ART at interval n = 546 n = 670 n = 706 n = 739 n = 772 n = 740
  Missed interview 462 (84.6) 508 (75.8) 528 (74.8) 544 (73.6) 542 (70.2) 473 (63.9)
  Non-mother caregiver gave interview 84 (15.4) 92 (13.7) 94 (13.3) 111 (15.0) 150 (19.4) 185 (25.0)
  No longer on ART 0 (0.00) 70 (10.5) 84 (11.9) 84 (11.4) 80 (10.4) 82 (11.1)
Adherence to NVP among infants reported on NVP
 Total number of infants assessed for adherence in interval n = 1145 n = 702 n = 426 n = 248 n = 125 n = 52
  Cumulative probability of adherencea 96.4 (94.3–97.8) 92.3 (89.8–94.2) 88.8 (85.9–91.2) 86.9 (83.6–89.6) 81.6 (76.9–85.5) 74.5 (70.2–81.9)
  Total adherence events during interval 1102 670 403 236 113 49
  Total nonadherence events during interval 43 32 23 12 12 3
   Taking ART but missed > 5% doses 8 (18.6) 12 (37.5) 5 (21.7) 3 (25.0) 5 (41.7) 0 (0.0)
   Stopped taking NVP during interval (not according to care) 35 (81.4) 20 (62.5) 18 (78.3) 9 (75.0) 7 (58.3) 3 (100.0)
Infants not included in the analysis during each interval and reason for exclusion
 Total number of infants not reporting on NVP at interval n = 1225 n = 1668 n = 1944 n = 2122 n = 2245 n = 2318
  Missed interview 338 (27.6) 405 (24.3) 437 (22.5) 448 (21.1) 425 (18.9) 389 (16.8)
  Appropriately stopped NVP 887 (72.4) 1263 (75.7) 1507 (77.5) 1674 (78.9) 1821 (81.1) 1929 (83.2)
   Never breastfed during interval 850 (95.8) 1183 (93.7) 1404 (93.2) 1542 (92.1) 1678 (92.2) 1784 (92.5)
   Clinician said to stop NVP 37 (4.2) 80 (6.3) 103 (6.8) 132 (7.9) 143 (7.8) 145 (7.5)
  1. aSurvivor function (probability of adherence) is calculated over full data and evaluated at indicated times; it is not calculated from aggregates shown in this table