Table 2 Comparison of mutant profiles in katG and inhA among INH-resistant isolates between 2005 and 2015
Mutation type | No. of INH-resistant isolates with different mutations (%) | P value | |
|---|---|---|---|
2005 (n = 82) | 2015 (n = 105) | ||
Single Mutation | |||
 inhA − 8 | 0(0.0) | 4(3.8) | 0.13 |
 inhA − 15 | 5(6.1) | 8(7.6) | 0.69 |
 katG 315 | 56(68.3) | 58(54.3) | 0.07 |
 Total | 61(74.4) | 70(65.7) | 0.25 |
Double Mutations | |||
 inhA − 8 + katG 315 | 3(3.7) | 4(3.8) | 1.00 |
 inhA − 15 + katG 315 | 4(4.9) | 12(11.4) | 0.11 |
 Total | 7(8.5) | 16(15.2) | 0.17 |
With mutations | |||
 inhA | 12(14.6) | 28(26.7) | 0.04 |
 katG | 63(76.8) | 74(70.5) | 0.33 |
Without mutation | 14(17.1) | 19(18.1) | 0.86 |