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Table 2 Comparison of mutant profiles in katG and inhA among INH-resistant isolates between 2005 and 2015

From: Change in prevalence and molecular characteristics of isoniazid-resistant tuberculosis over a 10-year period in China

Mutation type No. of INH-resistant isolates with different mutations (%) P value
2005
(n = 82)
2015
(n = 105)
Single Mutation
inhA − 8 0(0.0) 4(3.8) 0.13
inhA − 15 5(6.1) 8(7.6) 0.69
katG 315 56(68.3) 58(54.3) 0.07
 Total 61(74.4) 70(65.7) 0.25
Double Mutations
inhA − 8 + katG 315 3(3.7) 4(3.8) 1.00
inhA − 15 + katG 315 4(4.9) 12(11.4) 0.11
 Total 7(8.5) 16(15.2) 0.17
With mutations
inhA 12(14.6) 28(26.7) 0.04
katG 63(76.8) 74(70.5) 0.33
Without mutation 14(17.1) 19(18.1) 0.86