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Table 5 Comparison of different models of inheritance for the 7 selected SNPs

From: Genetic variants in Forkhead box O1 associated with predisposition to sepsis in a Chinese Han population

SNP Model Genotype Normal controls Sepsis patients p value p# value Survivors (n = 85) Nonsurvivors (n = 71) p value P# value
rs1126772 Codominant A/A 85 (57.05%) 90 (57.69%) 0.999 0.999 47 (55.29%) 44 (61.97%) 0.654 0.658
A/G 49 (32.88%) 52 (33.33%)    31 (36.47%) 21 (29.58%)   
G/G 12 (8.05%) 13 (8.33%)    7 (8.24%) 6 (8.45%)   
Dominant A/A 85 (57.05%) 90 (57.69%) 0.978 0.978 47 (55.29%) 44 (61.97%) 0.4 0.45
A/G-G/G 61 (42.95%) 65 (42.31%)    38 (44.71%) 27 (38.03%)   
Recessive A/A-A/G 134 (91.95%) 142 (91.67%) 0.958 0.968 7 (8.24%) 6 (8.45%) 0.961 0.963
G/G 12 (8.05%) 13 (8.33%)    78 (91.76%) 65 (91.55%)   
Overdominant A/A-G/G 97 (67.12%) 103 (66.03%) 0.998 0.999 54 (63.53%) 50 (70.42%) 0.363 0.363
A/G 49 (32.88%) 52 (33.33%)    31 (36.47%) 21 (29.58%)   
rs2269715 Codominant C/C 59 (39.6%) 58 (37.18%) 0.082 0.092 38 (44.71%) 20 (28.17%) 0.035 0.061
C/G 70 (46.98%) 79 (50.64%)    35 (41.18%) 44 (61.98%)   
G/G 19 (12.75%) 8 (5.13%)    12 (14.12%) 7 (9.86%)   
Dominant C/C 59 (39.6%) 58 (37.18%) 0.981 0.980 38 (44.71%) 20 (28.17%) 0.033 0.053
C/G-G/G 89 (60.4%) 87 (55.77%)    47 (55.29%) 51 (71.83%)   
Recessive C/C-C/G 129 (87.25%) 137 (87.82%) 0.03 0.03 73 (85.88%) 64 (90.14%) 0.418 0.420
G/G 19 (12.75%) 8 (5.13%)    12 (14.12%) 7 (9.86%)   
Overdominant C/C-G/G 78 (52.35%) 66 (42.31%) 0.219 0.219 50 (58.83%) 27 (38.02%) 0.01 0.021
C/G 70 (46.98%) 79 (50.64%)    35 (41.18%) 44 (61.98%)   
rs2721068 Codominant T/T 7 (4.7%) 19 (12.18%) 0.03 0.03 12 (14.12%) 7 (9.86%) 0.665 0.667
T/C 58 (38.93%) 66 (42.31%)    34 (40.0%) 32 (45.07%)   
C/C 84 (56.38%) 71 (45.51%)    39 (45.88%) 32 (45.07%)   
Dominant T/T 7 (4.7%) 19 (12.18%) 0.019 0.02 12 (14.12%) 7 (9.86%) 0.418 0.428
T/C-C/C 142 (95.3%) 137 (87.82%)    73 (85.88%) 64 (90.14%)   
Recessive T/T-T/C 65 (43.62%) 85 (54.49%) 0.058 0.058 46 (54.12%) 39 (54.93%) 0.919 0.920
C/C 84 (56.38%) 71 (45.51%)    39 (45.88%) 32 (45.07%)   
Overdominant T/T-C/C 92 (61.07%) 90 (57.69%) 0.517 0.520 51 (60.0%) 39 (54.93%) 0.523 0.525
T/C 58 (38.93%) 66 (42.31%)    34 (40.0%) 32 (45.07%)   
rs17446614 Codominant A/A 2 (1.34%) 3 (1.92%) 0.045 0.046 1 (1.18%) 2 (2.82%) 0.679 0.680
A/G 35 (23.49%) 20 (12.82%)    10 (11.76%) 10 (14.08%)   
G/G 110 (73.83%) 133 (85.25%)    74 (87.06%) 59 (83.10%)   
Dominant A/A 2 (1.34%) 3 (1.92%) 0.701 0.701 1 (1.18%) 2 (2.82%) 0.458 0.460
A/G-G/G 145 (97.32%) 153 (98.08%)    84 (98.82%) 69 (97.18%)   
Recessive A/A-A/G 37 (24.84%) 23 (14.75%) 0.023 0.023 11 (12.94%) 12 (16.90%) 0.487 0.489
G/G 110 (73.83%) 133 (85.25%)    74 (87.06%) 59 (83.10%)   
Overdominant A/A-G/G 112 (75.17%) 136 (87.18%) 0.013 0.013 75 (88.24%) 61 (85.92%) 0.666 0.667
A/G 35 (23.49%) 20 (12.82%)    10 (11.76%) 10 (14.08%)   
rs41317734 Codominant C/C 121 (81.21%) 133 (85.25%) 0.585 0.589 73 (85.88%) 60 (84.51%) 0.6 0.63
C/T 26 (17.45%) 22 (14.10%)    11 (12.94%) 11 (15.49%)   
T/T 2 (1.34%) 1 (0.64%)    1 (1.18%) 0 (0.00%)   
Dominant C/C 121 (81.21%) 133 (85.25%) 0.344 0.367 73 (85.88%) 60 (84.51%) 0.809 0.810
C/T-T/T 28 (18.79%) 23 (14.75%)    12 (14.12%) 11 (15.49%)   
Recessive C/C-C/T 147 (98.66%) 155 (99.36%) 0.535 0.535 84 (98.82%) 71 (100%) 0.359 0.360
T/T 2 (1.34%) 1 (0.64%)    1 (1.18%) 0 (0.00%)   
Overdominant C/C-T/T 123 (82.55%) 134 (85.90%) 0.422 0.435 74 (87.06%) 60 (84.51%) 0.648 0.659
C/T 26 (17.45%) 22 (14.10%)    11 (12.94%) 11 (15.49%)   
rs62464631 Codominant A/A 2 (1.34%) 1 (0.64%) 0.555 0.556 1 (1.18%) 0 (0.00%) 0.6 0.61
A/G 26 (17.45%) 22 (14.10%)    11 (12.94%) 11 (15.49%)   
G/G 119 (79.87%) 133 (85.25%)    73 (85.88%) 60 (84.51%)   
Dominant A/A 2 (1.34%) 1 (0.64%) 0.527 0.528 1 (1.18%) 0 (0.00%) 0.359 0.359
A/G-G/G 145 (97.32%) 155 (99.36%)    84 (98.82%) 71 (100%)   
Recessive A/A-A/G 28 (18.79%) 23 (14.75%) 0.317 0.318 12 (14.12%) 11 (15.49%) 0.809 0.812
G/G 119 (79.87%) 133 (85.25%)    73 (85.88%) 60 (84.51%)   
Overdominant A/A-G/G 121 (81.21%) 134 (85.90%) 0.393 0.393 74 (87.06%) 60 (84.51%) 0.648 0.648
A/G 26 (17.45%) 22 (14.10%)    11 (12.94%) 11 (15.49%)   
rs56952063 Codominant C/C 10 (6.71%) 7 (4.49%) 0.419 0.420 3 (3.53%) 4 (5.63%) 0.676 0.678
C/T 54 (36.24%) 67 (42.95%)    35 (41.18%) 32 (45.07%)   
T/T 84 (56.38%) 82 (43.10%)    47 (55.29%) 35 (49.30%)   
Dominant C/C 10 (6.71%) 7 (4.49%) 0.389 0.389 3 (3.53%) 4 (5.63%) 0.527 0.527
C/T-T/T 138 (92.62%) 149 (95.51%)    82 (96.47%) 67 (94.37%)   
Recessive C/C-C/T 64 (42.96%) 74 (56.90%) 0.463 0.470 38 (44.71%) 36 (50.70%) 0.455 0.456
T/T 84 (56.38%) 82 (43.10%)    47 (55.29%) 35 (49.30%)   
Overdominant C/C-T/T 94 (63.09%) 89 (57.05%) 0.25 0.26 50 (58.82%) 39 (54.93%) 0.625 0.626
C/T 54 (36.24%) 67 (42.95%)    35 (41.18%) 32 (45.07%)   
  1. P value: Chi-squared test or Fisher’s exact two-tailed tests; p# value: False discovery rate adjusted p value using the Benjamini-Hochberg method