SNP | Model | Genotype | Normal controls | Sepsis patients | p value | p# value | Survivors (n = 85) | Nonsurvivors (n = 71) | p value | P# value |
---|---|---|---|---|---|---|---|---|---|---|
rs1126772 | Codominant | A/A | 85 (57.05%) | 90 (57.69%) | 0.999 | 0.999 | 47 (55.29%) | 44 (61.97%) | 0.654 | 0.658 |
A/G | 49 (32.88%) | 52 (33.33%) | Â | Â | 31 (36.47%) | 21 (29.58%) | Â | Â | ||
G/G | 12 (8.05%) | 13 (8.33%) | Â | Â | 7 (8.24%) | 6 (8.45%) | Â | Â | ||
Dominant | A/A | 85 (57.05%) | 90 (57.69%) | 0.978 | 0.978 | 47 (55.29%) | 44 (61.97%) | 0.4 | 0.45 | |
A/G-G/G | 61 (42.95%) | 65 (42.31%) | Â | Â | 38 (44.71%) | 27 (38.03%) | Â | Â | ||
Recessive | A/A-A/G | 134 (91.95%) | 142 (91.67%) | 0.958 | 0.968 | 7 (8.24%) | 6 (8.45%) | 0.961 | 0.963 | |
G/G | 12 (8.05%) | 13 (8.33%) | Â | Â | 78 (91.76%) | 65 (91.55%) | Â | Â | ||
Overdominant | A/A-G/G | 97 (67.12%) | 103 (66.03%) | 0.998 | 0.999 | 54 (63.53%) | 50 (70.42%) | 0.363 | 0.363 | |
A/G | 49 (32.88%) | 52 (33.33%) | Â | Â | 31 (36.47%) | 21 (29.58%) | Â | Â | ||
rs2269715 | Codominant | C/C | 59 (39.6%) | 58 (37.18%) | 0.082 | 0.092 | 38 (44.71%) | 20 (28.17%) | 0.035 | 0.061 |
C/G | 70 (46.98%) | 79 (50.64%) | Â | Â | 35 (41.18%) | 44 (61.98%) | Â | Â | ||
G/G | 19 (12.75%) | 8 (5.13%) | Â | Â | 12 (14.12%) | 7 (9.86%) | Â | Â | ||
Dominant | C/C | 59 (39.6%) | 58 (37.18%) | 0.981 | 0.980 | 38 (44.71%) | 20 (28.17%) | 0.033 | 0.053 | |
C/G-G/G | 89 (60.4%) | 87 (55.77%) | Â | Â | 47 (55.29%) | 51 (71.83%) | Â | Â | ||
Recessive | C/C-C/G | 129 (87.25%) | 137 (87.82%) | 0.03 | 0.03 | 73 (85.88%) | 64 (90.14%) | 0.418 | 0.420 | |
G/G | 19 (12.75%) | 8 (5.13%) | Â | Â | 12 (14.12%) | 7 (9.86%) | Â | Â | ||
Overdominant | C/C-G/G | 78 (52.35%) | 66 (42.31%) | 0.219 | 0.219 | 50 (58.83%) | 27 (38.02%) | 0.01 | 0.021 | |
C/G | 70 (46.98%) | 79 (50.64%) | Â | Â | 35 (41.18%) | 44 (61.98%) | Â | Â | ||
rs2721068 | Codominant | T/T | 7 (4.7%) | 19 (12.18%) | 0.03 | 0.03 | 12 (14.12%) | 7 (9.86%) | 0.665 | 0.667 |
T/C | 58 (38.93%) | 66 (42.31%) | Â | Â | 34 (40.0%) | 32 (45.07%) | Â | Â | ||
C/C | 84 (56.38%) | 71 (45.51%) | Â | Â | 39 (45.88%) | 32 (45.07%) | Â | Â | ||
Dominant | T/T | 7 (4.7%) | 19 (12.18%) | 0.019 | 0.02 | 12 (14.12%) | 7 (9.86%) | 0.418 | 0.428 | |
T/C-C/C | 142 (95.3%) | 137 (87.82%) | Â | Â | 73 (85.88%) | 64 (90.14%) | Â | Â | ||
Recessive | T/T-T/C | 65 (43.62%) | 85 (54.49%) | 0.058 | 0.058 | 46 (54.12%) | 39 (54.93%) | 0.919 | 0.920 | |
C/C | 84 (56.38%) | 71 (45.51%) | Â | Â | 39 (45.88%) | 32 (45.07%) | Â | Â | ||
Overdominant | T/T-C/C | 92 (61.07%) | 90 (57.69%) | 0.517 | 0.520 | 51 (60.0%) | 39 (54.93%) | 0.523 | 0.525 | |
T/C | 58 (38.93%) | 66 (42.31%) | Â | Â | 34 (40.0%) | 32 (45.07%) | Â | Â | ||
rs17446614 | Codominant | A/A | 2 (1.34%) | 3 (1.92%) | 0.045 | 0.046 | 1 (1.18%) | 2 (2.82%) | 0.679 | 0.680 |
A/G | 35 (23.49%) | 20 (12.82%) | Â | Â | 10 (11.76%) | 10 (14.08%) | Â | Â | ||
G/G | 110 (73.83%) | 133 (85.25%) | Â | Â | 74 (87.06%) | 59 (83.10%) | Â | Â | ||
Dominant | A/A | 2 (1.34%) | 3 (1.92%) | 0.701 | 0.701 | 1 (1.18%) | 2 (2.82%) | 0.458 | 0.460 | |
A/G-G/G | 145 (97.32%) | 153 (98.08%) | Â | Â | 84 (98.82%) | 69 (97.18%) | Â | Â | ||
Recessive | A/A-A/G | 37 (24.84%) | 23 (14.75%) | 0.023 | 0.023 | 11 (12.94%) | 12 (16.90%) | 0.487 | 0.489 | |
G/G | 110 (73.83%) | 133 (85.25%) | Â | Â | 74 (87.06%) | 59 (83.10%) | Â | Â | ||
Overdominant | A/A-G/G | 112 (75.17%) | 136 (87.18%) | 0.013 | 0.013 | 75 (88.24%) | 61 (85.92%) | 0.666 | 0.667 | |
A/G | 35 (23.49%) | 20 (12.82%) | Â | Â | 10 (11.76%) | 10 (14.08%) | Â | Â | ||
rs41317734 | Codominant | C/C | 121 (81.21%) | 133 (85.25%) | 0.585 | 0.589 | 73 (85.88%) | 60 (84.51%) | 0.6 | 0.63 |
C/T | 26 (17.45%) | 22 (14.10%) | Â | Â | 11 (12.94%) | 11 (15.49%) | Â | Â | ||
T/T | 2 (1.34%) | 1 (0.64%) | Â | Â | 1 (1.18%) | 0 (0.00%) | Â | Â | ||
Dominant | C/C | 121 (81.21%) | 133 (85.25%) | 0.344 | 0.367 | 73 (85.88%) | 60 (84.51%) | 0.809 | 0.810 | |
C/T-T/T | 28 (18.79%) | 23 (14.75%) | Â | Â | 12 (14.12%) | 11 (15.49%) | Â | Â | ||
Recessive | C/C-C/T | 147 (98.66%) | 155 (99.36%) | 0.535 | 0.535 | 84 (98.82%) | 71 (100%) | 0.359 | 0.360 | |
T/T | 2 (1.34%) | 1 (0.64%) | Â | Â | 1 (1.18%) | 0 (0.00%) | Â | Â | ||
Overdominant | C/C-T/T | 123 (82.55%) | 134 (85.90%) | 0.422 | 0.435 | 74 (87.06%) | 60 (84.51%) | 0.648 | 0.659 | |
C/T | 26 (17.45%) | 22 (14.10%) | Â | Â | 11 (12.94%) | 11 (15.49%) | Â | Â | ||
rs62464631 | Codominant | A/A | 2 (1.34%) | 1 (0.64%) | 0.555 | 0.556 | 1 (1.18%) | 0 (0.00%) | 0.6 | 0.61 |
A/G | 26 (17.45%) | 22 (14.10%) | Â | Â | 11 (12.94%) | 11 (15.49%) | Â | Â | ||
G/G | 119 (79.87%) | 133 (85.25%) | Â | Â | 73 (85.88%) | 60 (84.51%) | Â | Â | ||
Dominant | A/A | 2 (1.34%) | 1 (0.64%) | 0.527 | 0.528 | 1 (1.18%) | 0 (0.00%) | 0.359 | 0.359 | |
A/G-G/G | 145 (97.32%) | 155 (99.36%) | Â | Â | 84 (98.82%) | 71 (100%) | Â | Â | ||
Recessive | A/A-A/G | 28 (18.79%) | 23 (14.75%) | 0.317 | 0.318 | 12 (14.12%) | 11 (15.49%) | 0.809 | 0.812 | |
G/G | 119 (79.87%) | 133 (85.25%) | Â | Â | 73 (85.88%) | 60 (84.51%) | Â | Â | ||
Overdominant | A/A-G/G | 121 (81.21%) | 134 (85.90%) | 0.393 | 0.393 | 74 (87.06%) | 60 (84.51%) | 0.648 | 0.648 | |
A/G | 26 (17.45%) | 22 (14.10%) | Â | Â | 11 (12.94%) | 11 (15.49%) | Â | Â | ||
rs56952063 | Codominant | C/C | 10 (6.71%) | 7 (4.49%) | 0.419 | 0.420 | 3 (3.53%) | 4 (5.63%) | 0.676 | 0.678 |
C/T | 54 (36.24%) | 67 (42.95%) | Â | Â | 35 (41.18%) | 32 (45.07%) | Â | Â | ||
T/T | 84 (56.38%) | 82 (43.10%) | Â | Â | 47 (55.29%) | 35 (49.30%) | Â | Â | ||
Dominant | C/C | 10 (6.71%) | 7 (4.49%) | 0.389 | 0.389 | 3 (3.53%) | 4 (5.63%) | 0.527 | 0.527 | |
C/T-T/T | 138 (92.62%) | 149 (95.51%) | Â | Â | 82 (96.47%) | 67 (94.37%) | Â | Â | ||
Recessive | C/C-C/T | 64 (42.96%) | 74 (56.90%) | 0.463 | 0.470 | 38 (44.71%) | 36 (50.70%) | 0.455 | 0.456 | |
T/T | 84 (56.38%) | 82 (43.10%) | Â | Â | 47 (55.29%) | 35 (49.30%) | Â | Â | ||
Overdominant | C/C-T/T | 94 (63.09%) | 89 (57.05%) | 0.25 | 0.26 | 50 (58.82%) | 39 (54.93%) | 0.625 | 0.626 | |
C/T | 54 (36.24%) | 67 (42.95%) | Â | Â | 35 (41.18%) | 32 (45.07%) | Â | Â |