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Table 1 Baseline characteristics and outcome of patients according to their pneumococcus colonization status

From: Prevalence and clinical impact of Streptococcus pneumoniae nasopharyngeal carriage in solid organ transplant recipients

 

Total n = 500

Not colonized n = 461

Colonized n = 39

P OR (CI95%)

Sex (male) - n (%)

322 (64.4)

291 (63.1)

31 (79.5)

<0.05 (0.20–0.98)

Age years, median (range)

54.4 (45–64)

54.5 (45–64)

53.8 (42–64)

ns

Type of transplant- n (%)

• Kidney

353 (70.6)

324 (70.3)

29 (74.4)

ns

• Liver

106 (21.2)

100 (21.7)

6 (15.4)

• Heart

39 (7.8)

35 (7.6)

4 (10.3)

• Liver-kidney

2 (0.4)

2 (0.4)

0 (0)

Time from transplant, median (range)

• 0–180 days

94 (18.8)

88 (19.1)

6 (15.4)

ns

• >180–360 days

34 (6.8)

31 (6.7)

3 (7.7)

• >1–5 years

139 (27.8)

131 (28.4)

8 (20.5)

• > 5 years

233 (46.6)

211 (45.8)

22 (56.4)

Charlson Comorbidity Index

• 0 point

110 (22)

103 (22.3)

7 (17.9)

ns

• 1 points

94 (18.8)

89 (19.3)

5 (12.8)

• 2 points

83 (16.6)

76 (16.5)

7 (17.9)

• ≥3 puntos

213 (42.6)

193 (41.9)

20 (51.3)

Cohabiting children- n (%)

172 (34.4)

149 (32.3)

23 (59)

0.001 (1.55–5.87)

• Children pneumococcal vaccination

18 (3.6)

17 (4.3)

1 (2.8)

ns

Prior pneumococcal infection- n (%)

44 (8.8)

38 (8.2)

6 (15.4)

ns

Prior pneumococcal vaccine- n (%)

121 (24.2)

115 (24.9)

6 (15.4)

ns

Baseline immunosuppression- n (%)

   

ns

• Tacrolimus

409 (81.8)

375 (81.3)

34 (87.2)

 

• Mycophenolate

377 (75.4)

347 (75.3)

30 (76.9)

• Ciclosporine

58 (11.6)

55 (11.9)

3 (7.7)

• mTOR

79 (15.8)

75 (16.3)

4 (10.3)

• Azathyoprine

10 (2)

10 (2.2)

0 (0)

• Glucocorticoids

326 (65.2)

304 (65.9)

22 (56.4)

Thymoglobulin induction < 6 m- n (%)

28 (5.6)

26 (5.6)

2 (5.1)

ns

Prior organ rejection

77 (15.4)

70 (15.2)

7 (17.9)

ns

Outcomes: - n (%)

• Pneumococcal infection

3

2 (0.4)

1 (2.5)

ns

• Death

9

9 (2)

0 (0)

 

• Rejection

2

2 (0.4)

0 (0)

 

• Graft loss

7

7 (1.6)

0 (0)

 
  1. Abbreviations: OR odds ratio, CI Confidence Interval, mTOR mammalian Target of Rapamycin, ns not significant