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Table 1 Baseline characteristics and outcome of patients according to their pneumococcus colonization status
| Total n = 500 | Not colonized n = 461 | Colonized n = 39 | P OR (CI95%) | |
|---|---|---|---|---|
| Sex (male) - n (%) | 322 (64.4) | 291 (63.1) | 31 (79.5) | <0.05 (0.20–0.98) |
| Age years, median (range) | 54.4 (45–64) | 54.5 (45–64) | 53.8 (42–64) | ns |
| Type of transplant- n (%) | ||||
| • Kidney | 353 (70.6) | 324 (70.3) | 29 (74.4) | ns |
| • Liver | 106 (21.2) | 100 (21.7) | 6 (15.4) | |
| • Heart | 39 (7.8) | 35 (7.6) | 4 (10.3) | |
| • Liver-kidney | 2 (0.4) | 2 (0.4) | 0 (0) | |
| Time from transplant, median (range) | ||||
| • 0–180 days | 94 (18.8) | 88 (19.1) | 6 (15.4) | ns |
| • >180–360 days | 34 (6.8) | 31 (6.7) | 3 (7.7) | |
| • >1–5 years | 139 (27.8) | 131 (28.4) | 8 (20.5) | |
| • > 5 years | 233 (46.6) | 211 (45.8) | 22 (56.4) | |
| Charlson Comorbidity Index | ||||
| • 0 point | 110 (22) | 103 (22.3) | 7 (17.9) | ns |
| • 1 points | 94 (18.8) | 89 (19.3) | 5 (12.8) | |
| • 2 points | 83 (16.6) | 76 (16.5) | 7 (17.9) | |
| • ≥3 puntos | 213 (42.6) | 193 (41.9) | 20 (51.3) | |
| Cohabiting children- n (%) | 172 (34.4) | 149 (32.3) | 23 (59) | 0.001 (1.55–5.87) |
| • Children pneumococcal vaccination | 18 (3.6) | 17 (4.3) | 1 (2.8) | ns |
| Prior pneumococcal infection- n (%) | 44 (8.8) | 38 (8.2) | 6 (15.4) | ns |
| Prior pneumococcal vaccine- n (%) | 121 (24.2) | 115 (24.9) | 6 (15.4) | ns |
| Baseline immunosuppression- n (%) | ns | |||
| • Tacrolimus | 409 (81.8) | 375 (81.3) | 34 (87.2) | |
| • Mycophenolate | 377 (75.4) | 347 (75.3) | 30 (76.9) | |
| • Ciclosporine | 58 (11.6) | 55 (11.9) | 3 (7.7) | |
| • mTOR | 79 (15.8) | 75 (16.3) | 4 (10.3) | |
| • Azathyoprine | 10 (2) | 10 (2.2) | 0 (0) | |
| • Glucocorticoids | 326 (65.2) | 304 (65.9) | 22 (56.4) | |
| Thymoglobulin induction < 6 m- n (%) | 28 (5.6) | 26 (5.6) | 2 (5.1) | ns |
| Prior organ rejection | 77 (15.4) | 70 (15.2) | 7 (17.9) | ns |
| Outcomes: - n (%) | ||||
| • Pneumococcal infection | 3 | 2 (0.4) | 1 (2.5) | ns |
| • Death | 9 | 9 (2) | 0 (0) | |
| • Rejection | 2 | 2 (0.4) | 0 (0) | |
| • Graft loss | 7 | 7 (1.6) | 0 (0) | |
