|
Sex (male) - n (%)
|
322 (64.4)
|
291 (63.1)
|
31 (79.5)
|
<0.05 (0.20–0.98)
|
|
Age years, median (range)
|
54.4 (45–64)
|
54.5 (45–64)
|
53.8 (42–64)
|
ns
|
|
Type of transplant- n (%)
|
|
• Kidney
|
353 (70.6)
|
324 (70.3)
|
29 (74.4)
|
ns
|
|
• Liver
|
106 (21.2)
|
100 (21.7)
|
6 (15.4)
|
|
• Heart
|
39 (7.8)
|
35 (7.6)
|
4 (10.3)
|
|
• Liver-kidney
|
2 (0.4)
|
2 (0.4)
|
0 (0)
|
|
Time from transplant, median (range)
|
|
• 0–180 days
|
94 (18.8)
|
88 (19.1)
|
6 (15.4)
|
ns
|
|
• >180–360 days
|
34 (6.8)
|
31 (6.7)
|
3 (7.7)
|
|
• >1–5 years
|
139 (27.8)
|
131 (28.4)
|
8 (20.5)
|
|
• > 5 years
|
233 (46.6)
|
211 (45.8)
|
22 (56.4)
|
|
Charlson Comorbidity Index
|
|
• 0 point
|
110 (22)
|
103 (22.3)
|
7 (17.9)
|
ns
|
|
• 1 points
|
94 (18.8)
|
89 (19.3)
|
5 (12.8)
|
|
• 2 points
|
83 (16.6)
|
76 (16.5)
|
7 (17.9)
|
|
• ≥3 puntos
|
213 (42.6)
|
193 (41.9)
|
20 (51.3)
|
|
Cohabiting children- n (%)
|
172 (34.4)
|
149 (32.3)
|
23 (59)
|
0.001 (1.55–5.87)
|
|
• Children pneumococcal vaccination
|
18 (3.6)
|
17 (4.3)
|
1 (2.8)
|
ns
|
|
Prior pneumococcal infection- n (%)
|
44 (8.8)
|
38 (8.2)
|
6 (15.4)
|
ns
|
|
Prior pneumococcal vaccine- n (%)
|
121 (24.2)
|
115 (24.9)
|
6 (15.4)
|
ns
|
|
Baseline immunosuppression- n (%)
| | | |
ns
|
|
• Tacrolimus
|
409 (81.8)
|
375 (81.3)
|
34 (87.2)
| |
|
• Mycophenolate
|
377 (75.4)
|
347 (75.3)
|
30 (76.9)
|
|
• Ciclosporine
|
58 (11.6)
|
55 (11.9)
|
3 (7.7)
|
|
• mTOR
|
79 (15.8)
|
75 (16.3)
|
4 (10.3)
|
|
• Azathyoprine
|
10 (2)
|
10 (2.2)
|
0 (0)
|
|
• Glucocorticoids
|
326 (65.2)
|
304 (65.9)
|
22 (56.4)
|
|
Thymoglobulin induction < 6 m- n (%)
|
28 (5.6)
|
26 (5.6)
|
2 (5.1)
|
ns
|
|
Prior organ rejection
|
77 (15.4)
|
70 (15.2)
|
7 (17.9)
|
ns
|
|
Outcomes: - n (%)
|
|
• Pneumococcal infection
|
3
|
2 (0.4)
|
1 (2.5)
|
ns
|
|
• Death
|
9
|
9 (2)
|
0 (0)
| |
|
• Rejection
|
2
|
2 (0.4)
|
0 (0)
| |
|
• Graft loss
|
7
|
7 (1.6)
|
0 (0)
| |
