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Table 1 ROC curve analysis for potential biomarkers for CP diagnosis

From: Identification of early biomarkers in a rabbit model of primary Candida pneumonia

 

AUC (95% CI)

Cut-off value

Sensitivity

Specificity

PCT

0.685 (0.420, 0.850)

1027.84 ng/L

75%

65%

sCD163

0.814 (0.678, 0.950)

16.44 U/mL

80%

75%

sTREM-1

0.882 (0.922, 0.976)

45.88 pg/mL

85%

80%

CRP

0.55 (0.363, 0.737)

0.944 mg/L

70%

55%

IL-6

0.724 (0.563, 0.844)

121.26 ng/L

70%

60%

IL-8

0.514 (0.333, 0.702)

73.63 ng/L

60%

50%

IL-10

0.620 (0.444, 0.796)

27.50 ng/L

60%

55%

TNF-α

0.74 (0.583, 0.897)

638.89 pg/mL

70%

60%

WBC

0.553 (0.371, 0.734)

5.38 × 109/L

55%

55%,

PaO2

0.333 (0.159, 0.506)

78 mmHg

50%

25%

  1. PCT: procalcitonin, sCD163: soluble hemoglobin-haptoglobin scavenger receptor, sTREM-1: soluble triggering receptor expressed on myeloid cells-1, CRP: C-reactive protein, IL-6: interleukin-6, IL-8: interleukin-8, IL-10: interleukin-10, TNF-α: tumor necrosis factor-α, WBC: white blood cell, PaO2: blood gas parameter, AUC: value of area under the ROC curve