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Table 1 ROC curve analysis for potential biomarkers for CP diagnosis

From: Identification of early biomarkers in a rabbit model of primary Candida pneumonia

  AUC (95% CI) Cut-off value Sensitivity Specificity
PCT 0.685 (0.420, 0.850) 1027.84 ng/L 75% 65%
sCD163 0.814 (0.678, 0.950) 16.44 U/mL 80% 75%
sTREM-1 0.882 (0.922, 0.976) 45.88 pg/mL 85% 80%
CRP 0.55 (0.363, 0.737) 0.944 mg/L 70% 55%
IL-6 0.724 (0.563, 0.844) 121.26 ng/L 70% 60%
IL-8 0.514 (0.333, 0.702) 73.63 ng/L 60% 50%
IL-10 0.620 (0.444, 0.796) 27.50 ng/L 60% 55%
TNF-α 0.74 (0.583, 0.897) 638.89 pg/mL 70% 60%
WBC 0.553 (0.371, 0.734) 5.38 × 109/L 55% 55%,
PaO2 0.333 (0.159, 0.506) 78 mmHg 50% 25%
  1. PCT: procalcitonin, sCD163: soluble hemoglobin-haptoglobin scavenger receptor, sTREM-1: soluble triggering receptor expressed on myeloid cells-1, CRP: C-reactive protein, IL-6: interleukin-6, IL-8: interleukin-8, IL-10: interleukin-10, TNF-α: tumor necrosis factor-α, WBC: white blood cell, PaO2: blood gas parameter, AUC: value of area under the ROC curve