| |
Death
|
Hospital admission
|
ICU admission
|
|---|
|
Variable
|
Adjusted odds ratio (95% CI)
|
p-value
|
Adjusted odds ratio (95% CI)
|
p-value
|
Adjusted odds ratio (95% CI)
|
p-value
|
|---|
|
Obesity
|
1.72 (1.17–2. 52)
|
0.005
|
1.49 (1.15–1.93)
|
0.002
|
2.93 (1.99–4.31)
|
< 0.001
|
|
Smoking
|
1.84 (1.04–3.25)
|
0.036
|
0.93 (0.71–1.22)
|
0.60
|
1.56 (0.81–3.00)
|
0.18
|
|
Chronic respiratory
|
0.92 (0.61–1.37)
|
0.67
|
2.30 (1.92–2.75)
|
< 0.001
|
1.20 (0.96–1.49)
|
0.10
|
|
Sensitivity Analysis
|
|
Pregnancy (core modelj)
|
1.00 (0.75–1.34)
|
1.00
|
6.80 (6.02–7.68)
|
< 0.001
|
0.57 (0.48–0.69)
|
< 0.001
|
|
Pregnancy (core model including obesity)
|
0.99 (0.71–1.38)a
|
0.93
|
6.83 (6.05–7.71)
d
|
< 0.001
|
0.91 (0.66–1.25)g
|
0.56
|
|
Pregnancy (core model including Smoking)
|
1.62 (1.03–2.56)
b
|
0.038
|
7.86 (6.94–8.90)
e
|
< 0.001
|
0.59 (0.35–0.99)
h
|
0.047
|
|
Pregnancy (core model including chronic respiratory)
|
0.99 (0.74–1.32)c
|
0.93
|
6.40 (5.58–7.33)
f
|
< 0.001
|
0.57 (0.47–0.68)
i
|
< 0.001
|
- a18542, 21 studies, b23064, 7 studies, c26948, 23 studies
- d17505, 7 studies, e22846, 4 studies, f23438, 6 studies
- g 2087, 20 studies, h1069, 11 studies, i5683, 23 studies
- jVariables included in the core model were age, antiviral use, vaccination (with the exception of ICU admission), cardio-respiratory illness, diabetes, and immunosuppression
- All variables and figures in bold are indeed statistically significant
