Variable | Univariate analysis | Multivariable analysisd | |||
---|---|---|---|---|---|
Odds ratio (95% CI) | p-value | Cases (studies) included | Adjusted odds ratio (95% CI) | p-value | |
Deatha | |||||
 Age (per 5-year increase) | 1.24 (1.19–1.29) | < 0.001 | 35,591 (32) | 1.19 (1.12–1.26) | < 0.001 |
 Pregnancy | 0.66 (0.54–0.81) | < 0.001 | 35,591 (32) | 1.00 (0.75–1.34) | 0.99 |
 Antiviral (yes) | 0.77 (0.63–0.96) | 0.017 | 32,652 (31) | 0.67 (0.49–0.90) | 0.009 |
 Vaccination | 0.50 (0.32–0.78) | 0.002 | 31,342 (26) | 0.41 (0.25–0.68) | < 0.001 |
 Cardio-respiratory | 1.41 (1.11–1.81) | 0.006 | 32,167 (31) | 1.30 (0.93–1.81) | 0.12 |
 Diabetes mellitus | 2.06 (1.54–2.75) | < 0.001 | 32,442 (31) | 1.67 (1.10–2.51) | 0.015 |
 Immunosuppressione | 2.37 (1.77–3.18) | < 0.001 | 31,995 (29) | 2.35 (1.56–3.55) | < 0.001 |
Hospitalizationb | |||||
 Age (per 5-year increase) | 1.08 (1.06–1.10) | < 0.001 | 27,972 (9) | 1.12 (1.09–1.15) | < 0.001 |
 Pregnancy | 5.33 (4.79–5.94) | < 0.001 | 27,972 (9) | 6.80 (6.02–7.68) | < 0.001 |
 Antiviral (yes) | 0.96 (0.86–1.07) | 0.45 | 25,814 (9) | 1.01 (0.89–1.14) | 0.89 |
 Vaccination | 0.88 (0.75–1.03) | 0.11 | 27,225 (8) | 0.91 (0.76–1.09) | 0.31 |
 Cardio-respiratory | 2.24 (1.91–2.62) | < 0.001 | 26,227 (9) | 2.28 (1.91–2.73) | < 0.001 |
 Diabetes | 1.00 (0.78–1.29) | 0.99 | 25,185 (8) | 0.92 (0.69–1.23) | 0.59 |
 Immunosuppressione | 1.16 (0.82–1.65) | 0.41 | 25,214 (9) | 1.05 (0.69–1.60) | 0.83 |
ICUc Admissionc | |||||
 Age (per 5-year increase) | 1.16 (1.13–1.20) | < 0.001 | 8836 (26) | 1.07 (1.03–1.11) | 0.003 |
 Pregnancy | 0.65 (0.57–0.74) | < 0.001 | 8836 (26) | 0.57 (0.48–0.69) | < 0.001 |
 Antiviral (yes) | 1.73 (1.48–2.01) | < 0.001 | 7769 (26) | 1.96 (1.63–2.35) | < 0.001 |
 Cardio-respiratory | 1.39 (1.19–1.63) | < 0.001 | 7152 (26) | 1.22 (1.01–1.48) | 0.043 |
 Diabetes | 1.81 (1.48–2.21) | < 0.001 | 8019 (26) | 1.58 (1.26–1.99) | < 0.001 |
 Immunosuppressione | 1.45 (1.18–1.78) | < 0.001 | 7516 (24) | 1.09 (0.86–1.39) | 0.48 |