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Table 2 Comparison of pregnant versus non-pregnant participants

From: Pregnancy as a risk factor for severe influenza infection: an individual participant data meta-analysis

 

Participant characteristics

Core model

 

Pregnant

(n = 4379, 12.0%)

Non-pregnant

(n = 32,119, 88.0%)

Risk estimate (95% CI)

 Mean age (years), SD

26.7 ± 6.1

29.2 ± 8.7

MD 2.43 (2.23–2.64)

 Antiviral treatment

2073 (55.4%)

8452 (28.7%)

OR 3.09 (2.88–3.31)

 Vaccinateda

367 (12.1%)

2221 (7.8%)

OR 1.62 (1.44–1.82)

 Diabetes mellitus

150 (3.9%)

1094 (3.8%)

OR 1.03 (0.86–1.22)

 Cardio-respiratory

287 (7.7%)

2186 (7.5%)

OR 1.03 (0.91–1.18)

 Immunosuppressionc

74 (2.0%)

814 (2.8%)

OR 0.69 (0.54–0.87)

Secondary model

 Obesity

107 (4.3%)

963 (4.7%)

OR 0.92 (0.75–1.13)

 Smoking

77 (4.6%)

762 (3.3%)

OR 1.43 (1.12–1.81)

 Chronic respiratoryb

251 (6.9%)

1907 (6.6%)

OR 1.05 (0.91–1.20)

  1. Abbreviations: SD Standard deviation, MD Mean difference, OR Odds ratio
  2. aVaccination status not included in the core model for the outcome ICU admission given > 20% missing data
  3. b‘Chronic respiratory’ replaced ‘cardio-respiratory’ from the core model in the secondary analysis
  4. c‘Immunosuppression’ includes participants with HIV positivity
  5. All variables and figures in bold are indeed statistically significant