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Table 1 Univariate analysis of SFCs to ESAT-6 or CFP-10 (nominal and ordinal variables)

From: Quantitative investigation of factors relevant to the T cell spot test for tuberculosis infection in active tuberculosis

VariableNSFCs to ESAT-6SFCs to CFP-10
SFCs/250000PBMCsTest valueP valueSFCs/250000PBMCsTest valueP value
Total36069.0 (24.3–148.3)  83.5 (23.0–218.3)  
Sex
 Female7987.0 (42.0–155.0)  97.0 (42.0–200.0)  
 Male28166.0 (22.5–134.5)Z = 12,681.50.05382.0 (21.0–227.0)Z = 11,627.50.518
Smokinga
 No14771.0 (37.0–143.0)  92.0 (29.0–234.0)  
 Yes21366.0 (20.0–150.0)Z = 14,353.00.18082.0 (21.5–205.5)Z = 15,138.00.594
Dust exposurea
 No25769.0 (27.0–146.5)  82.0 (22.0–200.0)  
 Yes10359.0 (19.0–150.0)Z = 12,438.50.37285.0 (28.0–237.0)Z = 13,966.00.413
Previously treated cases
 Nob25774.0 (28.5–150.0)  91.0 (23.0–235.5)  
 Yesc10354.0 (13.0–97.0)Z = 10,233.00.00165.0 (23.0–200.0)Z = 12,289.50.289
Cavitation
 No13772.0 (26.5–144.0)  91.0 (18.0–200.0)  
 Yes22367.0 (24.0–150.0)Z = 15,093.00.84982.0 (24.0–257.0)Z = 15,772.50.604
Extrapulmonary tuberculosis
 No29769.0 (24.0–150.0)  82.0 (23.0–200.0)  
 Yes6366.0 (25.0–114.0)Z = 8997.50.633121.0 (24.0–300.0)Z = 9996.50.393
Diabetes mellitus
 No33070.0 (24.8–150.0)  87.0 (24.0–220.3)  
 Yes3038.5 (22.0–89.5)Z = 3920.00.05949.5 (7.8–216.0)Z = 4321.00.249
Drug-resistant tuberculosis
 No32769.0 (25.0–150.0)  85.0 (23.0–220.0)  
 Yes3365.0 (15.5–134.5)Z = 5181.00.70771.0 (25.0–199.0)Z = 5409.00.981
Staged
 Minimal/Mild277.5 (0.0–77.50)  85.5 (22.0–85.5)  
 Moderate14378.0 (38.0–150.0)  97.0 (41.0–264.0)  
 Advanced21564.0 (22.0–126.0)SRCC = -0.0950.07182.0 (15.0–211.0)SRCC = 0.0000.995
Gradee
 DNA/RNA positive8068.0 (27.3–99.5)  84.0 (22.5–251.8)  
 The number of colony24104.0 (51.8–203.5)  132.5 (24.8–262.5)  
 1+10267.0 (21.8–150.0)  77.0 (22.8–205.0)  
 2+5059.5 (25.5–142.3)  81.0 (21.3–291.8)  
 3+7069.0 (24.5–150.0)  86.0 (26.8–200.0)  
 4+3465.5 (30.3–126.8)SRCC = -0.0750.15859.5 (19.3–154.8)SRCC = -0.0290.587
  1. Data are presented as N, median (interquartile range). There were no missing values
  2. a: Smoking or dust exposure for at least 3 months before a diagnosis of pulmonary tuberculosis
  3. b: New cases are defined as not starting anti-TB treatment or being on anti-TB treatment for <1 month
  4. c: Previously treated cases are defined as those anti-TB treated ≥1 month in the past
  5. d: The staging standard of National Tuberculosis Association of the United States of America
  6. e: Smear grading before treatment
  7. CFP-10 Culture filtrate protein 10 kDa, DNA Deoxyribonucleic acid, ESAT-6 Early secreted antigenic target 6 kDa, PBMCs Peripheral blood mononuclear cells, RNA Ribonucleic acid, SFCs Spot-forming cells, SRCC Spearman’s rho correlation coefficient, Z Wilcoxon’s rank sum test