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Table 1 Univariate analysis of SFCs to ESAT-6 or CFP-10 (nominal and ordinal variables)

From: Quantitative investigation of factors relevant to the T cell spot test for tuberculosis infection in active tuberculosis

Variable

N

SFCs to ESAT-6

SFCs to CFP-10

SFCs/250000PBMCs

Test value

P value

SFCs/250000PBMCs

Test value

P value

Total

360

69.0 (24.3–148.3)

  

83.5 (23.0–218.3)

  

Sex

 Female

79

87.0 (42.0–155.0)

  

97.0 (42.0–200.0)

  

 Male

281

66.0 (22.5–134.5)

Z = 12,681.5

0.053

82.0 (21.0–227.0)

Z = 11,627.5

0.518

Smokinga

 No

147

71.0 (37.0–143.0)

  

92.0 (29.0–234.0)

  

 Yes

213

66.0 (20.0–150.0)

Z = 14,353.0

0.180

82.0 (21.5–205.5)

Z = 15,138.0

0.594

Dust exposurea

 No

257

69.0 (27.0–146.5)

  

82.0 (22.0–200.0)

  

 Yes

103

59.0 (19.0–150.0)

Z = 12,438.5

0.372

85.0 (28.0–237.0)

Z = 13,966.0

0.413

Previously treated cases

 Nob

257

74.0 (28.5–150.0)

  

91.0 (23.0–235.5)

  

 Yesc

103

54.0 (13.0–97.0)

Z = 10,233.0

0.001

65.0 (23.0–200.0)

Z = 12,289.5

0.289

Cavitation

 No

137

72.0 (26.5–144.0)

  

91.0 (18.0–200.0)

  

 Yes

223

67.0 (24.0–150.0)

Z = 15,093.0

0.849

82.0 (24.0–257.0)

Z = 15,772.5

0.604

Extrapulmonary tuberculosis

 No

297

69.0 (24.0–150.0)

  

82.0 (23.0–200.0)

  

 Yes

63

66.0 (25.0–114.0)

Z = 8997.5

0.633

121.0 (24.0–300.0)

Z = 9996.5

0.393

Diabetes mellitus

 No

330

70.0 (24.8–150.0)

  

87.0 (24.0–220.3)

  

 Yes

30

38.5 (22.0–89.5)

Z = 3920.0

0.059

49.5 (7.8–216.0)

Z = 4321.0

0.249

Drug-resistant tuberculosis

 No

327

69.0 (25.0–150.0)

  

85.0 (23.0–220.0)

  

 Yes

33

65.0 (15.5–134.5)

Z = 5181.0

0.707

71.0 (25.0–199.0)

Z = 5409.0

0.981

Staged

 Minimal/Mild

2

77.5 (0.0–77.50)

  

85.5 (22.0–85.5)

  

 Moderate

143

78.0 (38.0–150.0)

  

97.0 (41.0–264.0)

  

 Advanced

215

64.0 (22.0–126.0)

SRCC = -0.095

0.071

82.0 (15.0–211.0)

SRCC = 0.000

0.995

Gradee

 DNA/RNA positive

80

68.0 (27.3–99.5)

  

84.0 (22.5–251.8)

  

 The number of colony

24

104.0 (51.8–203.5)

  

132.5 (24.8–262.5)

  

 1+

102

67.0 (21.8–150.0)

  

77.0 (22.8–205.0)

  

 2+

50

59.5 (25.5–142.3)

  

81.0 (21.3–291.8)

  

 3+

70

69.0 (24.5–150.0)

  

86.0 (26.8–200.0)

  

 4+

34

65.5 (30.3–126.8)

SRCC = -0.075

0.158

59.5 (19.3–154.8)

SRCC = -0.029

0.587

  1. Data are presented as N, median (interquartile range). There were no missing values
  2. a: Smoking or dust exposure for at least 3 months before a diagnosis of pulmonary tuberculosis
  3. b: New cases are defined as not starting anti-TB treatment or being on anti-TB treatment for <1 month
  4. c: Previously treated cases are defined as those anti-TB treated ≥1 month in the past
  5. d: The staging standard of National Tuberculosis Association of the United States of America
  6. e: Smear grading before treatment
  7. CFP-10 Culture filtrate protein 10 kDa, DNA Deoxyribonucleic acid, ESAT-6 Early secreted antigenic target 6 kDa, PBMCs Peripheral blood mononuclear cells, RNA Ribonucleic acid, SFCs Spot-forming cells, SRCC Spearman’s rho correlation coefficient, Z Wilcoxon’s rank sum test
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BMC Infectious Diseases

ISSN: 1471-2334

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