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Table 2 Comparison of demographics and clinical characteristics of hospitalized and non-hospitalized patients of HAdV infection between 2011 and 2014 epidemics

From: Comparative study of clinical and epidemiological characteristics of major pediatric adenovirus epidemics in southern Taiwan

Variables 2011 epidemics 2014 epidemics Significance of comparisons
Non-hospitalization Hospitalization Non-hospitalization Hospitalization P value1 P value2 P value3
Age 5.0 ± 3.1 4.4 ± 3.5 5.1 ± 3.3 4.7 ± 3.5 0.045 0.209 0546
Gender (M/F ratio) 1.08 1.57 1.33 1.63 0.072 0.297 0.671
Co-infection 7 (1.6) 8 (4.2) 6 (1.7) 16 (10.1) 0.081 < 0.001* 0.031
Underlying disease 29 (6.5) 28 (14.8) 8 (2.3) 23 (14.6) 0.001* < 0.001* 0.946
Diagnosis
 Acute pharyngitis/PCF 350 (78.5) 73 (38.6) 284 (80.7) 101 (63.9) < 0.001 < 0.001 < 0.001
 Bronchiolitis/bronchopneumonia 60 (13.5) 74 (39.2) 55 (15.6) 58 (36.7) < 0.001 < 0.001* 0.640
 Pneumonia 1 (0.2) 20 (10.6) 0 (0.0) 8 (5.1) < 0.001 < 0.001 0.006
 Acute gastro-enterocolitis 34 (7.6) 26 (13.8) 16 (4.5) 14 (8.9) 0.016 0.055 0.155
Clinical manifestation
 Fever 378 (84.8) 168 (88.9) 352 (100.0) 158 (100.0) 0.17 < 0.001*
 Injected throat 406 (91.0) 157 (83.1) 344 (97.7) 152 (96.2) 0.004 0.381 < 0.001*
 Cough 259 (58.1) 151 (79.9) 282 (80.1) 140 (88.6) < 0.001* 0.019 0.028*
 Rhinorrhea 229 (51.3) 112 (59.3) 271 (77.0) 132 (83.5) 0.067 0.093 < 0.001*
 Conjunctivitis 35 (7.8) 16 (8.5) 46 (13.1) 23 (14.6) 0.793 0.649 0.074
 Abdominal pain 66 (14.8) 33 (17.5) 59 (16.8) 30 (19.0) 0.398 0.540 0.713
 Diarrhea 97 (21.7) 56 (29.6) 43 (12.2) 44 (27.8) 0.034 < 0.001* 0.715
 Vomiting 146 (32.7) 72 (38.1) 75 (21.3) 61 (38.6) 0.193 < 0.001* 0.922
Laboratory monitor
 WBC (cells/μL) 5051 ± 6336 12,044 ± 5983 6000 ± 6683 13,130 ± 5825 < 0.001 < 0.001* 0.089
 ANC (cells/μL) 14,857 ± 77,292 8312 ± 5207 15,095 ± 101,895 9076 ± 4865 0.217 0.465 0.163
 ALC (cells/μL) 2138 ± 1500 2624 ± 2307 2456 ± 1608 2670 ± 2097 0.015 0.286 0.847
 CRP (mg/L) 47.6 ± 33.4 80.8 ± 71.5 52.4 ± 39.5 77.4 ± 63.3 < 0.001* < 0.001* 0.641
Survival rates 445 (99.8) 188 (99.5) 352 (100.0) 158 (100.0) 0.360
  1. Note: M/F ratio, male to female ratio; PCF, pharyngoconjunctival fever; WBC, white blood cell counts; ANC, absolute neutrophil counts; ALC, absolute lymphocyte counts; CRP, C-reactive protein
  2. 123, p-value of comparison between non-hospitalization and hospitalization in 12011 epidemics, 22014 epidemics, and p-value of 3comparison between 2011 and 2014 epidemics given hospitalization
  3. * P < 0.05