Skip to main content

Table 3 The CPA detection rates of each assay compared with the CPA diagnosis rate of gold standard

From: Prospective study of the serum Aspergillus-specific IgG, IgA and IgM assays for chronic pulmonary aspergillosis diagnosis

  Cut off value Sensitivity(95% CI) Specificity(95% CI) PLR(95% CI) NLP(95% CI) Kappa index P value
Aspergillus IgG test 89.3 AU/mLa 78.6% (62.8–89.2) 94.4% (89.3–97.2) 14.0 (7.3–26.9) 0.23 (0.13–0.41) 0.729 0.000
80.0 AU/mLb 78.6% (62.8–89.2) 89.4% (83.3–93.5) 7.4 (4.6–11.9) 0.24 (0.13–0.43) 0.635 0.000
120.0 AU/mLc 71.4% (55.2–83.8) 96.9% (92.5–98.8) 22.9 (9.4–55.3) 0.29 (0.18–0.48) 0.728 0.000
Aspergillus IgA test 8.2 U/mLa 64.3% (48.0–78.0) 89.4% (83.3–93.5) 6.1 (3.7–10.0) 0.40 (0.27–0.60) 0.527 0.000
8.0 U/mLb 66.7% (50.4–80.0) 84.4% (77.6–89.4) 4.3 (2.8–6.5) 0.39 (0.26–0.61) 0.465 0.000
12.0 U/mLc 47.6% (32.3–63.4) 95.6% (90.8–98.1) 10.9 (4.9–24.0) 0.55 (0.41–0.73) 0.498 0.000
Aspergillus IgM test 73.3 AU/mLa 50.0% (34.4–65.6) 53.7% (45.7–61.6) 1.1 (0.8–1.5) 0.93 (0.7–1.3) 0.026 0.665
80.0 AU/mLb 47.6% (32.3–63.4) 55.6% (47.6–63.4) 1.1 (0.8–1.5) 0.94 (0.7–1.3) 0.017 0.782
120.0 AU/mLc 21.4% (10.8–37.2) 68.8% (60.9–75.7) 0.7 (0.4–1.3) 1.14 (1.0–1.3) 0.085 0.213
GM test 0.50 μg/La 71.4% (55.2–83.8) 58.1% (50.1–65.8) 1.7 (1.3–2.2) 0.49 (0.3–0.8) 0.199 0.001
0.65μg/Lb 35.7% (22.0–52.0) 70.6% (62.8–77.4) 1.2 (0.8–1.9) 0.91 (0.7–1.1) 0.054 0.428
0.85μg/Lc 31.0% (18.1–47.2) 76.3% (68.8–82.5) 1.3 (0.8–2.2) 0.91 (0.7–1.1) 0.013 0.848
Aspergillus IgG + IgA testd 83.3% (68.0–92.5) 87.5% (81.1–92.0) 6.7 (4.3–10.3) 0.19 (0.1–0.4) 0.636 0.000
  1. aCut off value form this study
  2. blower detection limit of the kit
  3. cupper detection limit of the kit
  4. dcombined detection of Aspergillus IgG and IgA