Table 3 The CPA detection rates of each assay compared with the CPA diagnosis rate of gold standard
| Â | Cut off value | Sensitivity(95% CI) | Specificity(95% CI) | PLR(95% CI) | NLP(95% CI) | Kappa index | P value |
|---|---|---|---|---|---|---|---|
Aspergillus IgG test | 89.3 AU/mLa | 78.6% (62.8–89.2) | 94.4% (89.3–97.2) | 14.0 (7.3–26.9) | 0.23 (0.13–0.41) | 0.729 | 0.000 |
80.0 AU/mLb | 78.6% (62.8–89.2) | 89.4% (83.3–93.5) | 7.4 (4.6–11.9) | 0.24 (0.13–0.43) | 0.635 | 0.000 | |
120.0 AU/mLc | 71.4% (55.2–83.8) | 96.9% (92.5–98.8) | 22.9 (9.4–55.3) | 0.29 (0.18–0.48) | 0.728 | 0.000 | |
Aspergillus IgA test | 8.2 U/mLa | 64.3% (48.0–78.0) | 89.4% (83.3–93.5) | 6.1 (3.7–10.0) | 0.40 (0.27–0.60) | 0.527 | 0.000 |
8.0 U/mLb | 66.7% (50.4–80.0) | 84.4% (77.6–89.4) | 4.3 (2.8–6.5) | 0.39 (0.26–0.61) | 0.465 | 0.000 | |
12.0 U/mLc | 47.6% (32.3–63.4) | 95.6% (90.8–98.1) | 10.9 (4.9–24.0) | 0.55 (0.41–0.73) | 0.498 | 0.000 | |
Aspergillus IgM test | 73.3 AU/mLa | 50.0% (34.4–65.6) | 53.7% (45.7–61.6) | 1.1 (0.8–1.5) | 0.93 (0.7–1.3) | 0.026 | 0.665 |
80.0 AU/mLb | 47.6% (32.3–63.4) | 55.6% (47.6–63.4) | 1.1 (0.8–1.5) | 0.94 (0.7–1.3) | 0.017 | 0.782 | |
120.0 AU/mLc | 21.4% (10.8–37.2) | 68.8% (60.9–75.7) | 0.7 (0.4–1.3) | 1.14 (1.0–1.3) | 0.085 | 0.213 | |
GM test | 0.50 μg/La | 71.4% (55.2–83.8) | 58.1% (50.1–65.8) | 1.7 (1.3–2.2) | 0.49 (0.3–0.8) | 0.199 | 0.001 |
0.65μg/Lb | 35.7% (22.0–52.0) | 70.6% (62.8–77.4) | 1.2 (0.8–1.9) | 0.91 (0.7–1.1) | 0.054 | 0.428 | |
0.85μg/Lc | 31.0% (18.1–47.2) | 76.3% (68.8–82.5) | 1.3 (0.8–2.2) | 0.91 (0.7–1.1) | 0.013 | 0.848 | |
Aspergillus IgG + IgA testd | 83.3% (68.0–92.5) | 87.5% (81.1–92.0) | 6.7 (4.3–10.3) | 0.19 (0.1–0.4) | 0.636 | 0.000 | |