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Table 3 TB disease development associated with the ratio of neutrophil to lymphocyte (NL ratio) in sub-groups

From: Predicting the risk of pulmonary tuberculosis based on the neutrophil-to-lymphocyte ratio at TB screening in HIV-infected individuals

 TotalCasesUnivariate analysisMultivariate analysisa
Hazard Ratio (95% CI)p-valueAdjusted Hazard Ratio (95% CI)p-value
All (n = 1064)Low NL ratio67021 (3.1%)Reference< 0.001Reference0.007
High NL ratio39439 (9.9%)3.75 (2.21–6.38)2.19 (1.23–3.90)
TB symptoms (−)
+ Chest X ray (−)
(n = 545)
Low NL ratio3894 (1.0%)Reference0.014Reference0.276
High NL ratio1567 (4.5%)4.68 (1.37–16.00)2.10 (0.55–7.97)
TB symptoms (−)
+ Chest X ray (+)
(n = 131)
Low NL ratio852 (2.4%)reference0.074reference0.264
High NL ratio464 (8.7%)4.71 (0.85–25.82)3.08 (0.43–22.26)
TB symptoms (+)
+ Chest X ray (−)
(n = 263)
Low NL ratio13711 (8.0%)Reference0.016Reference0.035
High NL ratio12620 (15.9%)2.47 (1.18–5.18)2.58 (1.07–6.23)
TB symptoms (+)
+ Chest X ray (+)
(n = 119)
Low NL ratio554 (7.3%)Reference0.201Reference0.359
High NL ratio648 (12.5%)2.19 (0.66–7.31)1.90 (0.48–7.53)
CD4 counts:
< 50 (cells/mm3)
(n = 242)
Low NL ratio714 (5.6%)Reference0.062Reference0.045
High NL ratio17121 (12.3%)2.76 (0.94–8.07)3.17 (1.03–9.80)
CD4 counts:
50–199 (cells/mm3) (n = 269)
Low NL ratio15510 (6.3%)Reference0.043Reference0.084
High NL ratio11415 (8.8%)2.28 (1.03–5.10)2.10 (0.90–4.90)
CD4 counts:
> 200 (cells/mm3)
(n = 553)
Low NL ratio4447 (1.6%)Reference0.402Reference0.301
High NL ratio1093 (2.8%)1.78 (0.46–6.89)2.22 (0.49–10.15)
  1. TB Tuberculosis, HR Hazards ratio, CI Confidence interval, NL Neutrophil to lymphocyte
  2. a HR adjusted for age, sex, ethnicity, year of registration, CD4 counts, ART, TST results, abnormal chest x-ray, and TB symptoms