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Table 3 TB disease development associated with the ratio of neutrophil to lymphocyte (NL ratio) in sub-groups

From: Predicting the risk of pulmonary tuberculosis based on the neutrophil-to-lymphocyte ratio at TB screening in HIV-infected individuals

 

Total

Cases

Univariate analysis

Multivariate analysisa

Hazard Ratio (95% CI)

p-value

Adjusted Hazard Ratio (95% CI)

p-value

All (n = 1064)

Low NL ratio

670

21 (3.1%)

Reference

< 0.001

Reference

0.007

High NL ratio

394

39 (9.9%)

3.75 (2.21–6.38)

2.19 (1.23–3.90)

TB symptoms (−)

+ Chest X ray (−)

(n = 545)

Low NL ratio

389

4 (1.0%)

Reference

0.014

Reference

0.276

High NL ratio

156

7 (4.5%)

4.68 (1.37–16.00)

2.10 (0.55–7.97)

TB symptoms (−)

+ Chest X ray (+)

(n = 131)

Low NL ratio

85

2 (2.4%)

reference

0.074

reference

0.264

High NL ratio

46

4 (8.7%)

4.71 (0.85–25.82)

3.08 (0.43–22.26)

TB symptoms (+)

+ Chest X ray (−)

(n = 263)

Low NL ratio

137

11 (8.0%)

Reference

0.016

Reference

0.035

High NL ratio

126

20 (15.9%)

2.47 (1.18–5.18)

2.58 (1.07–6.23)

TB symptoms (+)

+ Chest X ray (+)

(n = 119)

Low NL ratio

55

4 (7.3%)

Reference

0.201

Reference

0.359

High NL ratio

64

8 (12.5%)

2.19 (0.66–7.31)

1.90 (0.48–7.53)

CD4 counts:

< 50 (cells/mm3)

(n = 242)

Low NL ratio

71

4 (5.6%)

Reference

0.062

Reference

0.045

High NL ratio

171

21 (12.3%)

2.76 (0.94–8.07)

3.17 (1.03–9.80)

CD4 counts:

50–199 (cells/mm3) (n = 269)

Low NL ratio

155

10 (6.3%)

Reference

0.043

Reference

0.084

High NL ratio

114

15 (8.8%)

2.28 (1.03–5.10)

2.10 (0.90–4.90)

CD4 counts:

> 200 (cells/mm3)

(n = 553)

Low NL ratio

444

7 (1.6%)

Reference

0.402

Reference

0.301

High NL ratio

109

3 (2.8%)

1.78 (0.46–6.89)

2.22 (0.49–10.15)

  1. TB Tuberculosis, HR Hazards ratio, CI Confidence interval, NL Neutrophil to lymphocyte
  2. a HR adjusted for age, sex, ethnicity, year of registration, CD4 counts, ART, TST results, abnormal chest x-ray, and TB symptoms