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Table 3 Predictive values of Pj PCR and betaglucan in serum at a pre-test probability of 20%

From: Serum-based diagnosis of Pneumocystis pneumonia by detection of Pneumocystis jirovecii DNA and 1,3-β-D-glucan in HIV-infected patients: a retrospective case control study

Index tests in serum

Positive predictive value

Negative predictive value

Pj PCR positive

0.46

1.0

Pj PCR with Ct ≤34a

0.71

0.99

BG ≥80 pg/mlb

0.45

0.99

BG ≥200 pg/mlb

0.63

0.98

BG ≥400 pg/mlb

0.69

0.97

Pj PCR positive and BG ≥200 pg/mlb

0.70

0.98

  1. Pj Pneumocystis jirovecii, PCP Pneumocystis jirovecii pneumonia, BG 1,3-ß-D-glucan
  2. The results are based on 26 patients with PCP and 21 HIV-infected negative controls
  3. aThree PCP patients whose serum samples had been analysed after 1:2 dilution were excluded
  4. bOne PCP patient whose serum sample was not analyzed for BG due to insufficient volume of serum was excluded
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BMC Infectious Diseases

ISSN: 1471-2334

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