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Table 1 General characteristics of the selected case-series

From: Fever of unknown origin (FUO): which are the factors influencing the final diagnosis? A 2005–2015 systematic review

Ref First Author Year Quality assessment (range 0–5) Country Geographical area Country income classification Model of study a FUO criteria b Study period Number of patients M/F ratio Mean age (range) Minimal diagnostic work-up
[11] Yu 2014 3 China Far East Upper- medium 1 1 2010–2011 107 54/53 48 (15–94) No
[12] Mir 2014 5 India Southern Asia Lower- medium 2 1 2010–2012 91 62/29 NA (16–80) No
[13] Naito 2013 4 Japan Far East High 1 1 2011 121 69/52 59 (19–94) No
[14] Robine 2014 5 France Europe High 1 1 2002–2012 103 54/49 57 (19–84) Yes
[15] Vanderschueren 2014 5 Belgium Europe High 1 3 2000–2010 436 NA 50 (NA) Yes
[16] Alavi 2013 3 Iran Middle East Upper -medium 1 3 2007–2011 106 57/49 50 (18–76) NA
[17] Mahmood 2013 3 Pakistan Southern Asia Lower- medium 1 1 2006–2011 205 111/94 38 (NA) No
[18] Shi 2013 5 China Far East Upper -medium 1 2 2004–2010 997 466/531 43 (14–85) No
[19] Mete 2012 3 Turkey Middle East Upper -medium 1 1 2001–2009 100 53/47 45 (16–82) Yesc
[20] Pedersen 2012 4 Denmark Europe High 1 1 2005–2010 52 36/16 48 (34–64) No
[21] Ali-Eldin 2011 3 Egypt Middle East Lower- medium 2 3 2009–2010 93 45/48 34 (NA) No
[22] Bandyopadhyay 2011 4 India Southern Asia Lower- medium 2 1 2008–2009 164 82/82 42 (NA) No
[23] Adil Khalil 2010 4 Iraq Middle East Upper -medium 2 1 2002–2009 55 27/28 43 (10–76) No
[24] Hu 2008 3 China Far East Upper -medium NA 2 2002–2003 142 69/73 49 (14–81) Yesc
[25] Kucukardali 2007 4 Turkey Middle East Upper -medium 2 1 2003–2004 154 83/71 42 (17–75) No
[3] Bleeker-Rovers 2007 5 Netherland Europe High 2 3 2003–2005 73 33/40 54 (26–87) Yes
[26] Colpan 2007 4 Turkey Middle East Upper -medium NA 3 2001–2004 71 40/31 42 (16–80) No
[27] Chin 2006 5 Taiwan Far East High 2 1 2001–2002 94 57/37 56 (18–86) Yes
  1. a Model of Study: 1, Retrospective; 2, Prospective; b FUO criteria: 1, Durak and Street; 2, Petersdorf and Beeson; 3, personal criteria; c Diagnostic work-up performed, but not detailed; NA Not Available