Skip to main content

Table 1 Characteristics of the included studies

From: Diagnostic accuracy of in-house real-time PCR assay for Mycobacterium tuberculosis: a systematic review and meta-analysis

Author

Year

Study design

Country

Number of participants

Number of samples sent for culture

Culture+/−

Type of test (target sequence)

Acid-fast stain

Culture

Respiratory specimen

Non-respiratory specimen

R/NR

TP

FP

FN

TN

Aggarwal 2012 [20]

Cross-sectional

India

80

80

18/62

16 s rRNA

?

MGIT

csf

0/80

12

14

6

48

Albuquerque 2014 [21]

Cross-sectional

Brazil

140

140

47/93

IS6110

ZN

7H9,LJ

sp

140/0

41

1

6

92

Barletta 2014 [10]

Cross-sectional

Peru

112

112

84/28

IS6110

ZN

LJ

sp

109/0

79

1

5

25

Chaidir 2013 [22]

Case-control

Indonesia

230

230

102/105

IS6110

ZN

Liquid and solid

csf

0/207

94

46

8

59

Darban-Sarokhalil 2012 [23]

Case-control

Iran

247

247

112/135

cyp141

ZN

LJ

sp

247/0

101

3

11

132

Gallo 2016 [24]

Cross-sectional

Brazil

?

1451

1351/100

mpt64

?

Liquid and solid

sp

1451/0

1347

4

4

96

Inoue 2011 [25]

Cross-sectional

Singapore

414

414

55/128

IS6110

?

MGIT

sp

csf,pf,ti

104/66

43

3

8

116

Lee 2011 [26]

Case-control

Korea

370

129

53/76

senX3-regX3

ZN

3% Ogawa

ti

ti

53/76

47

1

16

65

Lira, LA 2012 [27]

Case-control

Brazil

165

165

66/99

IS6110

ZN

LJ

sp

165/0

58

2

8

97

Lyra 2014 [28]

Cross-sectional

Brazil

181

194

11/91

IS6110

ZN

LJ

sp

102/0

11

3

0

88

Miller 2011 [29]

Cross-sectional

America

90

112

89/23

IS6110

?

MGIT, LJ,7H11

sp,ba,bal.,ti

In,ab,pf,ti

89/23

30

4

7

71

Rao 2016 [30]

Cross-sectional

India

100

200

44/56

16sRNA

?

MGIT

sp

100/0

44

2

0

54

Rozales 2014 [31]

Cross-sectional

Brazil

447

447

42/405

IS6110

ZN

7H9,MGIT

sp,bal

124/0

41

7

1

75

Sanjuan-Jimenez 2015 [32]

Case-control

Spain

153

145

76/69

senX3-regX3

ZN

LJ,MGIT

sp,ba,bal

pf,In,ur,csf,ar

125/20

65

0

11

69

Sanjuan-Jimenez 2015 [32]

Case-control

Spain

153

145

76/69

IS6110

ZN

LJ,MGIT

sp,ba,bal

pf,In,ur,csf,ar

125/20

72

9

4

60

  1. Acid-fast stain: ZN, Ziehl-Neelsen; Culture: MGIT, Mycobacteria growth indicator tube; LJ, Löwenstein-Jensen; 7H9, Middlebrook 7H9 Broth. Respiratory specimen: sp., sputum; ba, broncheal/tracheal aspirate; bal., bronchialalveolar lavage; ti, tissue specimen. Non-respiratory specimen: ln, lymph node; pf, pleural fluid; ar, articular fluid; ab, abcess/pus; ur, urine; csf, cerebrospinal fluid; ti, tissue sample. Specimen number: R, number of the respiratory specimens; NR, number of the non-respiratory specimens. “?” represents that the specific method is not mentioned in this paper. TP, true-positive; FP, false-positive; FN, false-negative; TN, true-negative