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Table 1 Characteristics of the included studies

From: Diagnostic accuracy of in-house real-time PCR assay for Mycobacterium tuberculosis: a systematic review and meta-analysis

Author
Year
Study design Country Number of participants Number of samples sent for culture Culture+/− Type of test (target sequence) Acid-fast stain Culture Respiratory specimen Non-respiratory specimen R/NR TP FP FN TN
Aggarwal 2012 [20] Cross-sectional India 80 80 18/62 16 s rRNA ? MGIT csf 0/80 12 14 6 48
Albuquerque 2014 [21] Cross-sectional Brazil 140 140 47/93 IS6110 ZN 7H9,LJ sp 140/0 41 1 6 92
Barletta 2014 [10] Cross-sectional Peru 112 112 84/28 IS6110 ZN LJ sp 109/0 79 1 5 25
Chaidir 2013 [22] Case-control Indonesia 230 230 102/105 IS6110 ZN Liquid and solid csf 0/207 94 46 8 59
Darban-Sarokhalil 2012 [23] Case-control Iran 247 247 112/135 cyp141 ZN LJ sp 247/0 101 3 11 132
Gallo 2016 [24] Cross-sectional Brazil ? 1451 1351/100 mpt64 ? Liquid and solid sp 1451/0 1347 4 4 96
Inoue 2011 [25] Cross-sectional Singapore 414 414 55/128 IS6110 ? MGIT sp csf,pf,ti 104/66 43 3 8 116
Lee 2011 [26] Case-control Korea 370 129 53/76 senX3-regX3 ZN 3% Ogawa ti ti 53/76 47 1 16 65
Lira, LA 2012 [27] Case-control Brazil 165 165 66/99 IS6110 ZN LJ sp 165/0 58 2 8 97
Lyra 2014 [28] Cross-sectional Brazil 181 194 11/91 IS6110 ZN LJ sp 102/0 11 3 0 88
Miller 2011 [29] Cross-sectional America 90 112 89/23 IS6110 ? MGIT, LJ,7H11 sp,ba,bal.,ti In,ab,pf,ti 89/23 30 4 7 71
Rao 2016 [30] Cross-sectional India 100 200 44/56 16sRNA ? MGIT sp 100/0 44 2 0 54
Rozales 2014 [31] Cross-sectional Brazil 447 447 42/405 IS6110 ZN 7H9,MGIT sp,bal 124/0 41 7 1 75
Sanjuan-Jimenez 2015 [32] Case-control Spain 153 145 76/69 senX3-regX3 ZN LJ,MGIT sp,ba,bal pf,In,ur,csf,ar 125/20 65 0 11 69
Sanjuan-Jimenez 2015 [32] Case-control Spain 153 145 76/69 IS6110 ZN LJ,MGIT sp,ba,bal pf,In,ur,csf,ar 125/20 72 9 4 60
  1. Acid-fast stain: ZN, Ziehl-Neelsen; Culture: MGIT, Mycobacteria growth indicator tube; LJ, Löwenstein-Jensen; 7H9, Middlebrook 7H9 Broth. Respiratory specimen: sp., sputum; ba, broncheal/tracheal aspirate; bal., bronchialalveolar lavage; ti, tissue specimen. Non-respiratory specimen: ln, lymph node; pf, pleural fluid; ar, articular fluid; ab, abcess/pus; ur, urine; csf, cerebrospinal fluid; ti, tissue sample. Specimen number: R, number of the respiratory specimens; NR, number of the non-respiratory specimens. “?” represents that the specific method is not mentioned in this paper. TP, true-positive; FP, false-positive; FN, false-negative; TN, true-negative