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Table 4 Subgroup analysis of N = 247 children with acute respiratory tract infection due to RSV-A ON1, stratified by setting and the first ON1 seasons (‘early’, 2011/12 to 2012/13) vs. later ON1 seasons (‘late’, 2013/14 to 2016/17); Bavaria (Germany), 2011/12–2016/17

From: Spread and clinical severity of respiratory syncytial virus A genotype ON1 in Germany, 2011–2017

  Pediatric practice (PP) Pediatric ward (PW) Pediatric intensive care unit (PICU)
Early ON1 Late ON1 p Early ON1 Late ON1 p Early ON1 Late ON1 p
N = 40 (100) N = 20 (100)   N = 67 (100) N = 71 (100) N = 30 (100) N = 19 (100)
Female sex 22 (55.0) 6 (30.0) 0.10 27 (40.3) 28 (37.4) 1.00 16 (53.3) 4 (21.1) 0.04
Age, years 2.6 (1.8; 3.9) 2.5 (2.1; 3.6) 0.84 1.1 (0.5; 2.2) 1.1 (0.5; 2.3) 0.87 0.2 (0.1; 1.0) 0.5 (0.2; 1.7) 0.19
Age, month 2.3 (1.5; 12.8) 5.8 (2.1; 20.0) 0.19
Premature birth 1 (2.5) 2 (10.0) 0.26 7 (10.4) 10 (14.1) 0.61 11 (36.7) 6 (31.6) 0.77
Other preexisting condition 6 (15.0) 0 (0) 0.17 19 (28.4) 33 (46.5) 0.04 6 (20.0) 7 (36.8) 0.32
Viral coinfection 20 (50.0) 9 (45.0) 0.78 23 (34.3) 23 (32.4) 0.86 15 (50.0) 7 (36.8) 0.40
Considered severe 1 (2.5) 0 (0) 1.00
Considered life threatening 4 (13.3) 3 (21.4) 0.66
Cough 32 (80.0) 16 (80.0) 1.00 52 (77.6) 55 (77.5) 1.00 27 (90.0) 14 (73.7) 0.23
Rhinitis 29 (72.5) 18 (90.0) 0.19 43 (64.2) 40 (56.3) 0.39 25 (83.3) 11 (57.9) 0.01
Refusal to eat / drink 4 (10.0) 1 (5.0) 0.66 38 (56.7) 27 (38.0) 0.04 15 (50.0) 10 (52.6) 1.00
Tachypnea 21 (31.3) 32 (45.1) 0.12 26 (86.7) 18 (94.7) 0.64
Fever 39 (100) 20 (100) 32 (47.8) 36 (50.7) 0.74 10 (33.3) 7 (36.8) 1.00
Fever, °C 39.7 (39.0; 40.1) 40.0 (39.1; 40.2) 0.41 38.7 (38.2; 39.2) 38.8 (38.3; 39.4) 0.35 38.8 (38.5; 39.1) 38.8 (38.1; 39.6) 0.77
Bronchitis / Bronchiolitis 19 (47.5) 7 (35.0) 0.42 37 (55.2) 31 (43.7) 0.23 22 (73.3) 15 (78.9) 0.74
Pneumonia 4 (1.0) 1 (5.0) 0.66 17 (25.4) 19 (26.8) 1.00 19 (63.3) 16 (84.2) 0.19
Sec. bac.pneumonia 0 (0) 1 (1.4) 1.00 7 (23.3) 8 (42.1) 0.21
Symptoms, days 11.0 (9.0; 14.0) 10.0 (7.0; 15.0) 0.92
Hospital stay, days 3.0 (2.0; 5.0) 3.0 (2.0; 5.0) 0.68 8.0 (6.0; 11.3) 10.0 (7.0; 14.0) 0.21
PICU stay, days 4.5 (3.0; 6.3) 5.0 (2.0; 10.0) 0.76
Oxygen 26 (38.8) 33 (46.5) 0.39 28 (93.3) 19 (100) 0.51
Oxygen, days 4.0 (3.3; 4.8) 3.0 (1.0; 5.0) 0.32 5.0 (4.0; 7.0) 8.5 (4.3; 14.3) 0.06
CPAP 0 (0) 0 (0) 15 (50.0) 5 (26.3) 0.14
CPAP, days 3.0 (2.0; 5.0) 2.0 (1.0; 2.0) 0.01
Mechanical ventilation 0 (0) 0 (0) 4 (13.3) 3 (15.8) 1.00
Mechanical ventilation, days 3.0 (1.0; −) 7.0 (6.0; −) 0.18
Well-being at discharge 67 (100) 70 (98.6) 1.00 30 (100) 18 (94.7) 0.39
Well-being 14 days past visit 33 (90.0) 17 (89.5) 1.00
  1. Data shown are number of cases (percent of N) or median (quartiles). P-values were derived using Fisher’s exact test or Mann-Whitney U-test, as appropriate. P-values in boldface indicate statistical significance