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Table 3 Subgroup analyses of N = 104 children with respiratory tract infection due to RSV-A admitted to PICU, stratified by premature birth status; Bavaria (Germany) 2010/11–2016/17

From: Spread and clinical severity of respiratory syncytial virus A genotype ON1 in Germany, 2011–2017

 

PICU

All children

PICU

Premature birth

PICU

Non-premature birth

 

ON1

non-ON1

p

ON1

non-ON1

p

ON1

non-ON1

p

 

N = 49 (100)

N = 55 (100)

N = 17 (100)

N = 9 (100)

N = 32 (100)

N = 46 (100)

Female sex

20 (40.8)

27 (49.1)

0.44

9 (52.9)

3 (33.3)

0.43

11 (34.4)

24 (52.2)

0.17

Age, month

3.4 (1.7; 18.3)

1.8 (1.5; 6.4)

0.02

3.4 (1.7; 23.6)

2.7 (1.7; 3.2)

0.39

3.6 (1.7; 18.4)

1.7 (1.4; 7.6)

0.05

Other preexisting conditiona

13 (26.5)

10 (18.2)

0.35

5 (29.4)

1 (11.1)

0.38

8 (25.0)

9 (19.6)

0.59

Viral coinfectionb

22 (44.9)

16 (29.1)

0.11

11 (64.7)

3 (33.3)

0.22

11 (34.4)

13 (28.3)

0.62

Hospital stay, days

8.0 (6.5; 12.0)

7.0 (5.0; 9.0)

0.02

8.0 (7.5; 14.0)

8.5 (7.3; 28.3)

0.66

8.0 (6.0; 12.0)

7.0 (5.0; 9.0)

0.02

PICU stay, days

5.0 (3.0; 7.5)

4.0 (2.0; 7.3)

0.23

3.0 (2.0; 8.5)

8.5 (3.3; 11.8)

0.27

5.0 (3.0; 6.0)

4.0 (2.0; 5.3)

0.06

Oxygen

47 (95.9)

46 (83.6)

0.06

17 (100)

6 (66.7)

0.03

30 (93.8)

40 (87.0)

0.46

Oxygen, days

6.0 (4.0; 9.0)

4.0 (2.0; 6.0)

0.03

5.0 (3.8; 9.0)

6.0 (4.0; 20.0)

0.35

6.0 (4.0; 9.0)

4.0 (2.0; 5.3)

0.01

CPAP

20 (40.8)

16 (29.1)

0.22

8 (47.0)

5 (55.6)

1.00

12 (37.5)

11 (23.9)

0.22

CPAP, days

2.5 (2.0; 4.8)

2.5 (2.0; 5.5)

0.89

3.0 (2.0; 4.5)

2.0 (2.0; 4.5)

0.70

2.0 (2.0; 4.8)

3.0 (2.0; 8.0)

0.66

  1. Data shown are number of cases (percent of N) or median (quartiles). P-values were derived using Fisher’s exact test or Mann-Whitney U-test, as appropriate. P-values in boldface indicate statistical significance
  2. aIncluded mainly chronic neurological disorders (14% of 104 patients), chronic lung disease (12%), cardiac malformations (7%), and genetic disorders (7%)
  3. bViral coinfections: 38 (37%) children with RSV-A were co-infected with at least one other respiratory virus, most frequently rhinovirus (n = 14) or coronavirus (n = 12)