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Table 3 Subgroup analyses of N = 104 children with respiratory tract infection due to RSV-A admitted to PICU, stratified by premature birth status; Bavaria (Germany) 2010/11–2016/17

From: Spread and clinical severity of respiratory syncytial virus A genotype ON1 in Germany, 2011–2017

  PICU
All children
PICU
Premature birth
PICU
Non-premature birth
  ON1 non-ON1 p ON1 non-ON1 p ON1 non-ON1 p
  N = 49 (100) N = 55 (100) N = 17 (100) N = 9 (100) N = 32 (100) N = 46 (100)
Female sex 20 (40.8) 27 (49.1) 0.44 9 (52.9) 3 (33.3) 0.43 11 (34.4) 24 (52.2) 0.17
Age, month 3.4 (1.7; 18.3) 1.8 (1.5; 6.4) 0.02 3.4 (1.7; 23.6) 2.7 (1.7; 3.2) 0.39 3.6 (1.7; 18.4) 1.7 (1.4; 7.6) 0.05
Other preexisting conditiona 13 (26.5) 10 (18.2) 0.35 5 (29.4) 1 (11.1) 0.38 8 (25.0) 9 (19.6) 0.59
Viral coinfectionb 22 (44.9) 16 (29.1) 0.11 11 (64.7) 3 (33.3) 0.22 11 (34.4) 13 (28.3) 0.62
Hospital stay, days 8.0 (6.5; 12.0) 7.0 (5.0; 9.0) 0.02 8.0 (7.5; 14.0) 8.5 (7.3; 28.3) 0.66 8.0 (6.0; 12.0) 7.0 (5.0; 9.0) 0.02
PICU stay, days 5.0 (3.0; 7.5) 4.0 (2.0; 7.3) 0.23 3.0 (2.0; 8.5) 8.5 (3.3; 11.8) 0.27 5.0 (3.0; 6.0) 4.0 (2.0; 5.3) 0.06
Oxygen 47 (95.9) 46 (83.6) 0.06 17 (100) 6 (66.7) 0.03 30 (93.8) 40 (87.0) 0.46
Oxygen, days 6.0 (4.0; 9.0) 4.0 (2.0; 6.0) 0.03 5.0 (3.8; 9.0) 6.0 (4.0; 20.0) 0.35 6.0 (4.0; 9.0) 4.0 (2.0; 5.3) 0.01
CPAP 20 (40.8) 16 (29.1) 0.22 8 (47.0) 5 (55.6) 1.00 12 (37.5) 11 (23.9) 0.22
CPAP, days 2.5 (2.0; 4.8) 2.5 (2.0; 5.5) 0.89 3.0 (2.0; 4.5) 2.0 (2.0; 4.5) 0.70 2.0 (2.0; 4.8) 3.0 (2.0; 8.0) 0.66
  1. Data shown are number of cases (percent of N) or median (quartiles). P-values were derived using Fisher’s exact test or Mann-Whitney U-test, as appropriate. P-values in boldface indicate statistical significance
  2. aIncluded mainly chronic neurological disorders (14% of 104 patients), chronic lung disease (12%), cardiac malformations (7%), and genetic disorders (7%)
  3. bViral coinfections: 38 (37%) children with RSV-A were co-infected with at least one other respiratory virus, most frequently rhinovirus (n = 14) or coronavirus (n = 12)