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Table 2 Characteristics of N = 341 children with acute respiratory tract infection due to RSV-A, stratified by settinga and RSV-A subtype (RSV-A ON1 vs. RSV-A non-ON1); Bavaria (Germany), 2010/11–2016/17

From: Spread and clinical severity of respiratory syncytial virus A genotype ON1 in Germany, 2011–2017

 

Pediatric practice (PP)

Pediatric ward (PW)

Pediatric intensive care unit (PICU)

 

ON1

non-ON1

p

ON1

non-ON1

p

ON1

non-ON1

p

 

N = 60 (100)

N = 12 (100)

N = 138 (100)

N = 27 (100)

N = 49 (100)

N = 55 (100)

Female sex

28 (46.7)

4 (33.3)

0.53

55 (39.9)

16 (59.3)

0.88

20 (40.8)

27 (49.1)

0.44

Age, years

2.5 (1.9; 3.7)

2.4 (1.9; 3.4)

0.75

1.1 (0.5; 2.3)

1.4 (0.6; 2.9)

0.50

0.3 (0.1; 1.5)

0.2 (0.1; 0.5)

0.02

Age, month

3.4 (1.7; 18.3)

1.8 (1.5; 6.4)

0.02

Premature birth

3 (5.0)

0 (0)

1.00

17 (12.3)

4 (14.8)

0.75

17 (34.7)

9 (16.4)

0.04

Other preexisting conditionb

6 (10.0)

2 (16.7)

0.61

52 (37.7)

6 (22.2)

0.19

13 (26.5)

10 (18.2)

0.35

Viral coinfectionc

29 (48.3)

7 (58.3)

0.75

46 (33.3)

12 (44.4)

0.28

22 (44.9)

16 (29.1)

0.11

Considered severe

1 (1.7)

1 (8.3)

0.31

Considered life threatening

7 (15.9)

10 (18.9)

0.79

Cough

48 (80.0)

9 (75.0)

0.71

107 (77.5)

27 (100)

< 0.01

41 (83.7)

44 (80.0)

0.80

Rhinitis

47 (78.3)

10 (83.3)

1.00

83 (60.1)

21 (77.8)

0.13

36 (73.5)

32 (58.2)

0.14

Refusal to eat / drink

5 (8.3)

1 (8.3)

1.00

65 (47.1)

17 (63.0)

0.15

25 (51.0)

35 (63.6)

0.24

Tachypnea

53 (38.4)

10 (37.0)

1.00

44 (89.8)

43 (78.2)

0.12

Fever

59 (100)

12 (100)

68 (49.3)

12 (44.4)

0.68

17 (34.7)

16 (29.1)

0.67

Fever, °C

39.8 (39.0; 40.2)

39.3 (39.1; 40.3)

0.91

38.7 (38.2; 39.3)

39.2 (38.5; 39.8)

0.07

38.8 (38.3; 39.0)

39.0 (38.8; 39.4)

0.20

Bronchitis / Bronchiolitis

26 (43.3)

4 (33.3)

0.75

68 (49.3)

9 (33.3)

0.15

37 (75.5)

47 (85.5)

0.22

Pneumonia

5 (8.3)

0 (0)

0.58

36 (26.1)

11 (40.7)

0.16

35 (71.4)

37 (67.3)

0.68

Sec. bacterial pneumonia

1 (0.7)

0 (0)

1.00

15 (30.6)

11 (20.0)

0.26

Symptoms, days

11 (8.5; 14)

10.5 (7; 13.5)

0.91

Hospital stay, days

3.0 (2.0; 5.0)

4.0 (3.0; 6.0)

0.10

8.0 (6.5; 12.0)

7.0 (5.0; 9.0)

0.02

PICU stay, days

5.0 (3.0; 7.5)

4.0 (2.0; 7.3)

0.23

Oxygen

59 (42.8)

12 (44.4)

1.00

47 (95.9)

46 (83.6)

0.06

Oxygen, days

3.0 (1.8; 5.0)

2.0 (1.8; 5.3)

0.77

6.0 (4.0; 9.0)

4.0 (2.0; 6.0)

0.03

CPAP

20 (40.8)

16 (29.1)

0.22

CPAP, days

2.5 (2.0; 4.8)

2.5 (2.0; 5.5)

0.89

Mechanical ventilation

7 (14.3)

4 (7.3)

0.34

Mechanical ventilation, days

6.5 (2.5, 8.5)

6.0 (2.3; 12.0)

0.91

Well-being at discharge

137 (99.3)

27 (100)

1.00

48 (98.0)

53 (96.4)

1.00

Well-being 14 days past visit

53 (89.8)

11 (91.7)

1.00

  1. Data shown are number of cases (percent of N) or median (quartiles). P-values were derived using Fisher’s exact test or Mann-Whitney U-test, as appropriate. P-values in boldface indicate statistical significance
  2. aNote that data from PP, PW and PICU were collected during different seasons (PP: 2012/13–2014/15, PW: 2011/12–2016/17, PICU: 2010/11–2016/17), and in different age groups (PP 1–5 years, PW and PICU up to 16 years)
  3. bIncluding mainly chronic lung disease (11% of 341patients), chronic neurological disorders (9%), cardiac malformation (6%), and immunocompromising conditions (4%)
  4. cRefers to coinfection with a different respiratory virus detected in the initial multiplex PCR