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Table 2 Comparison of PCR and culture results for detecting S. pneumoniae among children in Palwal, India

From: Nasopharyngeal carriage of Streptococcus pneumoniae serotypes among children in India prior to the introduction of pneumococcal conjugate vaccines: a cross-sectional study

 

Children with suspected pneumonia (n = 91)

Children in the community (n = 510)

Culture positive, n (%)

61 (67.0)

268 (52.6)

PCR positive, n (%)

64 (70.3)

259 (50.8)

Culture or PCR positive, n (%)

68 (74.7)

278 (54.5)

PCR positive/culture positive, n (%)

57 (62.6)

249 (48.8)

PCR positive/culture negative, n (%) a

7 (7.7)

10 (2.0)

PCR negative/culture positive, n (%) b

4 (4.4)

19 (3.7)

PCR negative/culture negative, n (%)

23 (25.3)

232 (45.5)

Multiple serotypes present if culture positive, n (%)

1 (1.1)

7 (1.4)

Multiple serotypes present if PCR positive, n (%)

14 (15.4)

21 (4.1)

Multiple serotypes present if culture or PCR positive, n (%)

18 (19.8)

29 (5.7)

  1. aSerotypes: children with clinical pneumonia: 6A/B/C/D, 10A, 19A, 23F, 31, 35F/47F, 39; community children: 5, 7C/B/40, 9 N/L, 10F/C/33C, 14, 16F, 24F/A/B, 25F/A/38, 34, 35B
  2. bSerotypes: children with clinical pneumonia: 33B; community children: 10B, 27, 33B, 48, non-typeable