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Table 4 Univariable and multivariable semi-parametric proportional hazard model on predictors with time to second-line treatment failure among adults living with HIV in Amhara Region (February 2008–April 2016)

From: Incidence and predictors of second-line antiretroviral treatment failure among adults living with HIV in Amhara region: a multi-centered retrospective follow-up study

Variables Crude hazard ratio (95%CI) Adjusted hazard ratio(95%CI)
Age
 15–24 Reference Reference
 25–34 0.85 (0.56 1.29) 0.91 (0.60 1.39)
 35–44 0.81 (0.52 1.25) 0.85 (0.54 1.32)
  ≥ 45 0.76 (0.45 1.28) 0.86 (0.50 1.47)
Gender
 Female Reference Reference
 male 1.10 (0.86 1.41) 1.18 (0.91 1.53)
BMI(kg/m2)
  < 18.5 1.26 (0.98 1.62) 1.09 (0.83 1.42)
 18.5–24.99 Reference Reference
  > 25 0.67 (0.39 1.20) 0.76 (0.44 1.33)
CD4 count at switch
  ≥ 100 cells/mm3 Reference Reference
  < 100 cells/mm3 0.82 (0.64 1.05) 0.88 (0.68 1.14)
Regimen modification
 Yes Reference Reference
 No 1.65 (1.27 2.14) 1.55 (1.18 2.04)
ART adherence
 good Reference Reference
 Fair 1.11 (0.78 1.59) 1.12 (0.78 1.61)
 poor 1.55 (1.18 2.03) 1.40 (1.06 1.85)
WHO clinical stage
 I Reference Reference
 II 0.95 (0.59 1.53) 0.84 (0.52 1.39)
 III 0.78 (0.59 1.04) 0.68 (0.50 0.91)
 IV 1.44 (0.98 2.11) 1.14 (0.75 1.73)
Isoniazid Preventive Therapy (INH) given
 Yes Reference Reference
 No 1.70 (1.25 2.32) 1.68 (1.23 2.30)
Functional status at switch
 Working Reference Reference
 Ambulatory 1.45 (1.03 2.04) 1.42 (0.97 2.07)
 bedridden 1.99 (0.98 4.05) 1.94 (0.93 4.05)
Opportunistic Infections (OI)
 Yes Reference Reference
 No 1.00 (0.62 1.62) 0.98 (0.60 1.61)
Second-line regimen
 ABC-ddI-LPV/r Reference Reference
 TDF-3TC-LPV/r 1.59 (1.08 2.35) 1.55 (1.03 2.32)
 AZT-3TC-LPV/r 2.85(1.79 4.53) 3.00 (1.86 4.85)
 Othersa 1.89(1.28 2.82) 1.77 (1.19 2.67)
  1. a = (ABC-ddI-NFV, AZT-3TC-ATV/r, TDF-3TC-ATV/r, ABC-3TC-LPV/r, and ABC-3TC-ATV/r)