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Table 2 Leishmania spp. Antibiogram of ATCC© and Clinical Isolates Resistant at Varying Concentrations of Amphotericin B and Fluconazole

From: Susceptibility testing of Leishmania spp. against amphotericin B and fluconazole using the Sensititre™ YeastOne™ YO9 platform

Species Total Number of Isolates Amphotericin B (μg/mL) Fluconazole (μg/mL)
0.12 0.25 0.5 1 ≥256
Old World
 L. donovani ATCC®50212™ 3 3 (100%) 0 (0%) 0 (0%) 0 (0%) 3 (100%)
 L. infantum ATCC®50134™ 5 2 (40%) 1 (20%) 0 (0%) 0 (0%) 5 (100%)
 Clinical L. infantum 3 0 (0%) 0 (0%) 0 (0%) 0 (0%) 3 (100%)
 L. tropica ATCC®50129™ 3 3 (100%) 0 (0%) 0 (0%) 0 (0%) 3 (100%)
 Clinical L. tropica 6 6 (100%) 0 (0%) 0 (0%) 0 (0%) 6 (100%)
 L. major ATCC®50122™ 4 4 (100%) 3 (75%) 0 (0%) 0 (0%) 4 (100%)
New World
 L. amazonensis ATCC®50159™ 3 3 (100%) 2 (66.6%) 1 (33.3%) 0 (0%) 3 (100%)
 L. chagasi ATCC®50133™ 3 3 (100%) 1 (33.3%) 0 (0%) 0 (0%) 3 (100%)
 L. mexicana ATCC®50157™ 3 3 (100%) 1 (33.3%) 0 (0%) 0 (0%) 3 (100%)
 L. V. braziliensis ATCC® 50135™ 3 3 (100%) 0 (0%) 0 (0%) 0 (0%) 3 (100%)
 Clinical L. V. braziliensis 3 3 (100%) 3 (100%) 0 (0%) 0 (0%) 3 (100%)
 L. V. guyanensis ATCC®50126™ 4 2 (50%) 1 (25%) 0 (0%) 0 (0%) 4 (100%)
 L. V. panamensis ATCC®50158™ 3 3 (100%) 3 (100%) 0 (0%) 0 (0%) 3 (100%)
 Clinical L. V. panamensis 15 4 (27%) 3 (25%) 1 (8.3%) 0 (0%) 15 (100%)
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BMC Infectious Diseases

ISSN: 1471-2334

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