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Table 2 Characteristics of studies included in the review

From: A systematic review of the epidemiology of hepatitis A in Africa

Author, Year (Citation) Study Design Year(s) of Data Collection Country Population Sample Size (n) Outcome Measures Study Objective
Abdulla et al., 2010 [22] Cross-sectional 2006 to 2008 General Africa Children & adolescents 29 IgG To determine the prevalence of acute hepatitis A virus infection and immunity among internationally adopted children
Afegbua et al., 2013 [27] Cross-sectional 2009 Nigeria Children & adolescents 403 IgG To determine seroprevalence of HAV among schoolchildren and adolescents in Kaduna State and identify factors associated with seropositivity
Al-Aziz et al., 2008 [28] Cohort 2008 Egypt Children & adolescents 296 IgG To determine the seroprevalence of HAV antibodies among group of children
Blanchi et al., 2014 [23] Cohort 2009 to 2012 General Africa Children 146 IgM To describe infectious diseases in internationally adopted children
Bonney et al., 2013 [29] Cross-sectional 2008 to 2011 Ghana All ages 285 IgM To determine if viral hemorrhagic fevers and viral hepatitides contribute to hospital morbidity in the Central and Northern parts of Ghana
Bouskraoui et al., 2009 [30] Cross-sectional 2005 to 2006 Morrocco Children & adolescents 150 IgG To assess the prevalence of viral hepatitis A infection in febrile icteric children and to examine the main risk factors of transmission
Burrous et al., 2010 [31] Cross-sectional 2006 to 2008 Morrocco Children & adolescents 129 IgM To assess the prevalence of viral hepatitis A infection in febrile icteric children and to examine the main risk factors of transmission
El-Karasksy et al., 2008 [32] Cohort 2005 Egypt Children & adolescents 172 IgG To determine the prevalence of anti-hepatitis A virus antibodies among 172 children with chronic liver disease
Ellis et al., 2008 [33] Cohort 2008 Mali Children 36 IgM Phase 1 study in Malian children of the blood stage malaria vaccine
Enoch et al., 2019 [21] Cross-sectional 2009 to 2015 South Africa Children 482 IgG To determine the seroprevalence of hepatitis A infection in the Western Cape Province of South Africa
Forbi et al., 2012 [34] Cohort 2012 Cameroon Children 78 IgM To undertake genetic analysis of the hepatitis A virus associated with cases of acute diarrhea among children under five in Cameroon
Forbi et al., 2012_2 [35] Cross-sectional 2006 Nigeria Adults 114 IgM To investigate HAV strains among apparently healthy adult Nigerian subjects
Guenifi et al., 2017 [36] Cross-sectional 2010 to 2011 Algeria Children 1061 IgG To estimate the seroprevalence of hepatitis A virus infection in the district of Setif
Ikobah et al., 2015 [37] Cross-sectional 2012 Nigeria Children & adolescents 406 IgG To determine the seroprevalence and predictors of viral hepatitis A in children aged 1 to 18 years
Jablonka et al., 2017 [38] Cross-sectional 2015 General Africa All ages 55 IgG To determine the seroprevalence of anti-HAV IgG in refugees in Germany
Klouwenberg et al., 2011 [39] Cohort 2011 Kenya Children 222 IgM To determine the temporal pattern of a co-infection of P. falciparum malaria and acute HAV in a cohort of Kenyan children under the age of five
Lopes et al., 2017 [40] Cross-sectional 2015 South Africa All ages 300 IgG To determine the seroprevalence of HAV and HEV antibodies in blood donors giving at the Western Province Blood Transfusion Service
Louati et al., 2009 [41] Cross-sectional 2007 Tunisia Adults 376 IgG To assess hepatitis A virus seroprevalence in blood donors from South Tunisia in two periods; 200 and 2007
Majori et al., 2008 [26] Cross-sectional 2008 General Africa All ages 182 IgG & IgM To assess the seroprevalence of viral hepatitis infections in sub-Saharan immigrants living in Italy
Mazanderani et al., 2018 [11] Cross-sectional 2005 to 2015 South Africa All ages 501083 IgG & IgM To assess seroprevalence rates among specimens tested for HAV serology within South Africa’s public health sector
Mphaka et al., 2016 [42] Cross-sectional 2016 South Africa Children & adolescents 46 IgM To respond to an increase in blood samples testing positive for HAV IgM
Murchiri et al., 2012 [43] Cross-sectional 2007 to 2008 Kenya Adults 100 IgM To determine seroprevalence of HAV, HBV HCV and HEV among patients with acute hepatitis in Nairobi Kenya
Nagu et al., 2008 [44] Cross-sectional 2006 Tanzania Adults 260 IgM To determine the prevalence and predictors of viral hepatitis co-infection among HIV-infected individuals presenting at the HIV care and treatment clinics in the country
Neffatti et al., 2017 [45] Cross-sectional 2014 to 2015 Tunisia Adults 216 IgG To supplement lacking data on hepatitis A and E from rural areas of South Tunisia
Ogefere et al., 2016 [46] Cross-sectional 2016 Nigeria All ages 200 IgM To determine the seroprevalence of anti-HAV IgM in an at-risk population in Benin City and to identify the social, demographic and other risk factors
Raabe et al., 2014 [24] Cross-sectional 2014 General Africa Children 656 IgM To assess the need to recommend routine HAV vaccination in internationally adopted children
Rabenau et al., 2010 [47] Cohort 2007 Lesotho Adults 205 IgG To screen international adoptees for acute HAV infection
Rezig et al., 2008 [48] Cross-sectional 2008 Algeria Children & adolescents 3357 IgG To assess the seroprevalence of coinfecting viruses in a cohort of 205 HIV-infected individuals
Smahi et al., 2009 [49] Cross-sectional 2006 Algeria Children 252 IgG To determine the seroprevalence of hepatitis A and E infections
Sule et al., 2013 [50] Cross-sectional 2010 to 2011 Nigeria All ages 91 IgG To determine the prevalence of anti-hepatitis A virus IgG antibody and associated factors among residents of Osogbo
Tantawy et al., 2012 [51] Case-control 2009 to 2010 Egypt Children & adolescents 182 IgG To evaluate the seroprevalence of hepatitis A in Egyptian patients with haemophilia A
Traore et al., 2012 Cross-sectional 2010 to 2012 Burkina Faso Adults 91 IgG & IgM To assess the seroprevalence of antibodies to both HAV and HEV in central Burkina Faso in the absence of a recorded hepatitis epidemic
  1. Abbreviations: HAV Hepatitis A virus, IgG Immunoglobin class G, HBV Hepatitis B virus, HCV Hepatitis C virus, HEV Hepatitis E virus