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Table 2 Characteristics of studies included in the review

From: A systematic review of the epidemiology of hepatitis A in Africa

Author, Year (Citation)

Study Design

Year(s) of Data Collection

Country

Population

Sample Size (n)

Outcome Measures

Study Objective

Abdulla et al., 2010 [22]

Cross-sectional

2006 to 2008

General Africa

Children & adolescents

29

IgG

To determine the prevalence of acute hepatitis A virus infection and immunity among internationally adopted children

Afegbua et al., 2013 [27]

Cross-sectional

2009

Nigeria

Children & adolescents

403

IgG

To determine seroprevalence of HAV among schoolchildren and adolescents in Kaduna State and identify factors associated with seropositivity

Al-Aziz et al., 2008 [28]

Cohort

2008

Egypt

Children & adolescents

296

IgG

To determine the seroprevalence of HAV antibodies among group of children

Blanchi et al., 2014 [23]

Cohort

2009 to 2012

General Africa

Children

146

IgM

To describe infectious diseases in internationally adopted children

Bonney et al., 2013 [29]

Cross-sectional

2008 to 2011

Ghana

All ages

285

IgM

To determine if viral hemorrhagic fevers and viral hepatitides contribute to hospital morbidity in the Central and Northern parts of Ghana

Bouskraoui et al., 2009 [30]

Cross-sectional

2005 to 2006

Morrocco

Children & adolescents

150

IgG

To assess the prevalence of viral hepatitis A infection in febrile icteric children and to examine the main risk factors of transmission

Burrous et al., 2010 [31]

Cross-sectional

2006 to 2008

Morrocco

Children & adolescents

129

IgM

To assess the prevalence of viral hepatitis A infection in febrile icteric children and to examine the main risk factors of transmission

El-Karasksy et al., 2008 [32]

Cohort

2005

Egypt

Children & adolescents

172

IgG

To determine the prevalence of anti-hepatitis A virus antibodies among 172 children with chronic liver disease

Ellis et al., 2008 [33]

Cohort

2008

Mali

Children

36

IgM

Phase 1 study in Malian children of the blood stage malaria vaccine

Enoch et al., 2019 [21]

Cross-sectional

2009 to 2015

South Africa

Children

482

IgG

To determine the seroprevalence of hepatitis A infection in the Western Cape Province of South Africa

Forbi et al., 2012 [34]

Cohort

2012

Cameroon

Children

78

IgM

To undertake genetic analysis of the hepatitis A virus associated with cases of acute diarrhea among children under five in Cameroon

Forbi et al., 2012_2 [35]

Cross-sectional

2006

Nigeria

Adults

114

IgM

To investigate HAV strains among apparently healthy adult Nigerian subjects

Guenifi et al., 2017 [36]

Cross-sectional

2010 to 2011

Algeria

Children

1061

IgG

To estimate the seroprevalence of hepatitis A virus infection in the district of Setif

Ikobah et al., 2015 [37]

Cross-sectional

2012

Nigeria

Children & adolescents

406

IgG

To determine the seroprevalence and predictors of viral hepatitis A in children aged 1 to 18 years

Jablonka et al., 2017 [38]

Cross-sectional

2015

General Africa

All ages

55

IgG

To determine the seroprevalence of anti-HAV IgG in refugees in Germany

Klouwenberg et al., 2011 [39]

Cohort

2011

Kenya

Children

222

IgM

To determine the temporal pattern of a co-infection of P. falciparum malaria and acute HAV in a cohort of Kenyan children under the age of five

Lopes et al., 2017 [40]

Cross-sectional

2015

South Africa

All ages

300

IgG

To determine the seroprevalence of HAV and HEV antibodies in blood donors giving at the Western Province Blood Transfusion Service

Louati et al., 2009 [41]

Cross-sectional

2007

Tunisia

Adults

376

IgG

To assess hepatitis A virus seroprevalence in blood donors from South Tunisia in two periods; 200 and 2007

Majori et al., 2008 [26]

Cross-sectional

2008

General Africa

All ages

182

IgG & IgM

To assess the seroprevalence of viral hepatitis infections in sub-Saharan immigrants living in Italy

Mazanderani et al., 2018 [11]

Cross-sectional

2005 to 2015

South Africa

All ages

501083

IgG & IgM

To assess seroprevalence rates among specimens tested for HAV serology within South Africa’s public health sector

Mphaka et al., 2016 [42]

Cross-sectional

2016

South Africa

Children & adolescents

46

IgM

To respond to an increase in blood samples testing positive for HAV IgM

Murchiri et al., 2012 [43]

Cross-sectional

2007 to 2008

Kenya

Adults

100

IgM

To determine seroprevalence of HAV, HBV HCV and HEV among patients with acute hepatitis in Nairobi Kenya

Nagu et al., 2008 [44]

Cross-sectional

2006

Tanzania

Adults

260

IgM

To determine the prevalence and predictors of viral hepatitis co-infection among HIV-infected individuals presenting at the HIV care and treatment clinics in the country

Neffatti et al., 2017 [45]

Cross-sectional

2014 to 2015

Tunisia

Adults

216

IgG

To supplement lacking data on hepatitis A and E from rural areas of South Tunisia

Ogefere et al., 2016 [46]

Cross-sectional

2016

Nigeria

All ages

200

IgM

To determine the seroprevalence of anti-HAV IgM in an at-risk population in Benin City and to identify the social, demographic and other risk factors

Raabe et al., 2014 [24]

Cross-sectional

2014

General Africa

Children

656

IgM

To assess the need to recommend routine HAV vaccination in internationally adopted children

Rabenau et al., 2010 [47]

Cohort

2007

Lesotho

Adults

205

IgG

To screen international adoptees for acute HAV infection

Rezig et al., 2008 [48]

Cross-sectional

2008

Algeria

Children & adolescents

3357

IgG

To assess the seroprevalence of coinfecting viruses in a cohort of 205 HIV-infected individuals

Smahi et al., 2009 [49]

Cross-sectional

2006

Algeria

Children

252

IgG

To determine the seroprevalence of hepatitis A and E infections

Sule et al., 2013 [50]

Cross-sectional

2010 to 2011

Nigeria

All ages

91

IgG

To determine the prevalence of anti-hepatitis A virus IgG antibody and associated factors among residents of Osogbo

Tantawy et al., 2012 [51]

Case-control

2009 to 2010

Egypt

Children & adolescents

182

IgG

To evaluate the seroprevalence of hepatitis A in Egyptian patients with haemophilia A

Traore et al., 2012

Cross-sectional

2010 to 2012

Burkina Faso

Adults

91

IgG & IgM

To assess the seroprevalence of antibodies to both HAV and HEV in central Burkina Faso in the absence of a recorded hepatitis epidemic

  1. Abbreviations: HAV Hepatitis A virus, IgG Immunoglobin class G, HBV Hepatitis B virus, HCV Hepatitis C virus, HEV Hepatitis E virus