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Table 4 Risk factors associated with a weak humoral response to each of the three vaccine antigens contained in the adjuvanted influenza vaccine Fluad® among individuals ≥65 years of aged

From: Self-reported diabetes and herpes zoster are associated with a weak humoral response to the seasonal influenza A H1N1 vaccine antigen among the elderly

Variables A H1N1 A H3N2 B
UOR & 95% CI AOR & 95% CI UOR & 95% CI AOR & 95% CI UOR & 95% CI AOR & 95% CI
Female vs. male 1.21 (0.69–2.13) 1.36 (0.73–2.50) 0.52 (0.22–1.26) 0.48 (0.19–1.20) 0.74 (0.41–1.32) 0.78 (0.42–1.46)
Age (change per year) 1.06 (0.99–1.13) 1.08 (0.99–1.16) 0.99 (0.90–1.09) 1.01 (0.91–1.12) 1.05 (0.98–1.12) 1.03 (0.96–1.11)
BMI (change per unit)a 1.02 (0.96–1.08) 1.01 (0.94–1.08) 1.00 (0.91–1.10) 0.99 (0.89–1.09) 0.96 (0.90–1.03) 0.98 (0.91–1.05)
Hypertensionb 0.73 (0.42–1.28) 0.67 (0.36–1.23) 0.82 (0.37–1.86) 0.94 (0.40–2.19) 1.05 (0.59–1.87) 0.94 (0.51–1.72)
Diabetesc 5.11 (1.40–18.53) 4.64 (1.16–18.54) 1.53 (0.41–5.76) 1.16 (0.24–5.65) 0.37 (0.10–1.35) 0.58 (0.14–2.29)
Cancerc 1.39 (0.69–2.79) 1.26 (0.58–2.69) 0.88 (0.31–2.50) 0.73 (0.24–2.25) 1.74 (0.86–3.52) 1.57 (0.74–3.31)
Heart attackc 3.41 (0.89–13.01) 2.78 (0.64–12.15) 3.54 (0.99–12.71) 3.39 (0.80–14.40) 0.32 (0.07–1.49) 0.44 (0.09–2.21)
Herpes zosterc 1.99 (0.94–4.23) 2.27 (1.01–5.10) 2.71 (1.10–6.69) 3.12 (1.18–8.23) 1.03 (0.48–2.20) 0.96 (0.43–2.12)
CMV (change per unit) 1.00 (0.99–1.00) 1.00 (0.99–1.00) 1.00 (0.99–1.01) 1.00 (0.99–1.01) 1.00 (0.99–1.00) 1.00 (0.99–1.00)
  1. BMI Body mass index, CMV Cytomegalovirus, UOR Unadjusted odds ratio, AOR Adjusted odds ratio, CI Confidence intervals
  2. aWeight and height were measured at the study center (see Methods). BMI was calculated using the formula “weight/height2” (kg/m2)
  3. bBlood pressure was measured at the study center (see Methods). Hypertension was defined as a systolic or diastolic blood pressure ≥ 140 mmHg and/or 90 mmHg, respectively
  4. cSelf-reported information
  5. dResults of fractional polynomial regression. Robust independent risk factors (underlined) were defined as those with lower bound 95% CI of AOR not crossing below 1