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Table 4 Comparison of treatment outcomes between specific drug-containing regimens by drug-resistance pattern (MDR- VS- pre-XDR TB)

From: Towards tailored regimens in the treatment of drug-resistant tuberculosis: a retrospective study in two Italian reference Centres

  MDR-TB Pre-XDR TB p-value
Clofazimine-containing regimens n = 8 n = 17  
Treatment outcome, n (%) Cured 5 (62.5) 7 (41.2) 0.41
Treatment completed 2 (25.0) 6 (35.3) 1.0
Died 1 (12.5) 3 (17.7) 1.0
Default 1 (5.9) 1.0
Transferred out
Treatment success 7 (87.5) 13 (76.5) 1.0
Linezolid-containing regimens n = 23 n = 23  
Treatment outcome, n (%) Cured 17 (73.9) 12 (52.2) 0.22
Treatment completed 3 (13.0) 8 (34.8) 0.17
Died 1 (4.4) 3 (13.0) 0.61
Default 1 (4.4) 1.0
Transferred out 1 (4.4) 1.0
Treatment success 20 (87.0) 20 (87.0) 1.0
Meropenem-containing regimens n = 22 n = 23  
Treatment outcome, n (%) Cured 20 (90.9) 12 (52.2) 0.007
Treatment completed 0 (0.0) 8 (34.8) 0.004
Died 2 (9.1) 3 (13.0) 1.0
Default  
Transferred out  
Treatment success 20 (90.9) 20 (87.0) 1.0
Fluoroquinolones-containing regimens n = 88 n = 31  
Treatment outcome, n (%) Cured 39 (44.3) 13 (41.9) 0.82
Treatment completed 33 (37.5) 11 (35.5) 0.84
Died 3 (3.4) 3 (9.7) 0.18
Default 9 (10.2) 1 (3.2) 0.45
Transferred out 4 (4.6) 3 (9.7) 0.38
Treatment success 72 (81.8) 24 (77.4) 0.59
Amikacin-containing regimens n = 43 n = 22  
Treatment outcome, n (%) Cured 28 (65.1) 8 (36.4) 0.03
Treatment completed 11 (25.6) 10 (45.5) 0.11
Died 2 (4.7) 2 (9.1) 0.60
Default 1 (2.3) 1.0
Transferred out 1 (2.3) 2 (9.1) 0.26
Treatment success 39 (90.7) 18 (81.8) 0.43