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Table 3 Comparison of treatment outcomes between specific drug-containing regimens

From: Towards tailored regimens in the treatment of drug-resistant tuberculosis: a retrospective study in two Italian reference Centres

  Not exposed Exposed p-value
Clofazimine-containing regimens (n = 109) (n = 25)  
Treatment outcome, n (%) Cured 45 (41.3) 12 (48.0) 0.13
Treatment completed 44 (40.4) 8 (32.0)
Died 4 (3.7) 4 (16.0)
Default 9 (8.3) 1 (4.0)
Transferred out 7 (6.4) 0 (0.0)
Linezolid-containing regimens (n = 88) (n = 46)  
Treatment outcome, n (%) Cured 28 (31.8) 29 (63.0) 0.001
Treatment completed 41 (46.6) 11 (23.9) 0.01
Died 4 (4.6) 4 (8.7) 0.44
Default 9 (10.2) 1 (2.2) 0.16
Transferred out 6 (6.8) 1 (2.2) 0.42
Meropenem-containing regimens (n = 89) (n = 45)  
Treatment outcome, n (%) Cured 25 (28.1) 32 (71.1) < 0.0001
Treatment completed 44 (49.4) 8 (17.8) < 0.0001
Died 3 (3.4) 5 (11.1) 0.12
Default 10 (11.2) 0 (0.0) 0.02
Transferred out 7 (7.9) 0 (0.0) 0.10
Fluoroquinolones-containing regimens (n = 15) (n = 119)  
Treatment outcome, n (%) Cured 5 (33.3) 52 (43.7) 0.33
Treatment completed 8 (53.3) 44 (37.0)
Died 2 (13.3) 6 (5.0)
Default 0 (0.0) 10 (8.4)
Transferred out 0 (0.0) 7 (5.9)
Amikacin-containing regimens (n = 69) (n = 65)  
Treatment outcome, n (%) Cured 21 (30.4) 36 (55.4) 0.004
Treatment completed 31 (44.9) 21 (32.3) 0.13
Died 4 (5.8) 4 (6.2) 1.0
Default 9 (13.0) 1 (1.5) 0.02
Transferred out 4 (5.8) 3 (4.6) 1.0