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Table 3 Comparison of treatment outcomes between specific drug-containing regimens

From: Towards tailored regimens in the treatment of drug-resistant tuberculosis: a retrospective study in two Italian reference Centres

 

Not exposed

Exposed

p-value

Clofazimine-containing regimens

(n = 109)

(n = 25)

 

Treatment outcome, n (%)

Cured

45 (41.3)

12 (48.0)

0.13

Treatment completed

44 (40.4)

8 (32.0)

Died

4 (3.7)

4 (16.0)

Default

9 (8.3)

1 (4.0)

Transferred out

7 (6.4)

0 (0.0)

Linezolid-containing regimens

(n = 88)

(n = 46)

 

Treatment outcome, n (%)

Cured

28 (31.8)

29 (63.0)

0.001

Treatment completed

41 (46.6)

11 (23.9)

0.01

Died

4 (4.6)

4 (8.7)

0.44

Default

9 (10.2)

1 (2.2)

0.16

Transferred out

6 (6.8)

1 (2.2)

0.42

Meropenem-containing regimens

(n = 89)

(n = 45)

 

Treatment outcome, n (%)

Cured

25 (28.1)

32 (71.1)

< 0.0001

Treatment completed

44 (49.4)

8 (17.8)

< 0.0001

Died

3 (3.4)

5 (11.1)

0.12

Default

10 (11.2)

0 (0.0)

0.02

Transferred out

7 (7.9)

0 (0.0)

0.10

Fluoroquinolones-containing regimens

(n = 15)

(n = 119)

 

Treatment outcome, n (%)

Cured

5 (33.3)

52 (43.7)

0.33

Treatment completed

8 (53.3)

44 (37.0)

Died

2 (13.3)

6 (5.0)

Default

0 (0.0)

10 (8.4)

Transferred out

0 (0.0)

7 (5.9)

Amikacin-containing regimens

(n = 69)

(n = 65)

 

Treatment outcome, n (%)

Cured

21 (30.4)

36 (55.4)

0.004

Treatment completed

31 (44.9)

21 (32.3)

0.13

Died

4 (5.8)

4 (6.2)

1.0

Default

9 (13.0)

1 (1.5)

0.02

Transferred out

4 (5.8)

3 (4.6)

1.0