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Fig. 2 | BMC Infectious Diseases

Fig. 2

From: Genomic characterization of MDR/XDR-TB in Kazakhstan by a combination of high-throughput methods predominantly shows the ongoing transmission of L2/Beijing 94–32 central Asian/Russian clusters

Fig. 2

Six QGIS® built genetic maps of Kazakhstan showing Mycobacterium tuberculosis based on samples recruited respectively in 2001 (n = 91), 2008 (n = 152) and 2014–2015 (n = 632) a: from top to bottom: The L2/Beijing (Blue) and L4-Euro-American (Red) relative prevalence based on three different studies published in 2005 (Kubica et al.), 2015 (Skiba et al.) and in this study suggests an increase of prevalence of L2 relatively to L4. b: from top to bottom: the assessment of epidemiological clusters, done by different methods (IS6110-RFLP by Kubica et al. 2005, MLVA by Skiba et al. 2005; a SNP-based (SigE) specific for the 94–32 cluster found in this study, shows a dynamic increase towards the prevalence of a very limited number of variants of the 94–32 cluster. Red stars identifies majors IS6110-RFLP clusters 4 and 6, identified in the 2001 study

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