Skip to main content

Table 2 Treatment outcome at month 6 and 12 in relation to the nucleoside analogue used

From: A viral genome wide association study and genotypic resistance testing in patients failing first line antiretroviral therapy in the first large countrywide Ethiopian HIV cohort

Time point

All: n (%)

Tenofovir

Zidovudine

d4T

p-value

Baselinea

874

467/874; 53.4%

362/874; 41.4%

44/874; 5.0%)

NA

Month 6b

743/874; 85.1%

391/467; 83.7%

313/362; 86.5%

39/44; 88.6%

0.591

 with VL; still on treatment

676/743; 91.0%

350/391; 89.5%

288/313; 92.0%

38/39; 97.4%

0.225

 VL > 150c

90/676; 13.3%

52/350; 15.0%

34/288; 11.8%

4/38; 10.5%

0.956

 VL > 1000c

57/676; 8.4%

34/350; 9.7%

19/288; 6.6%

4/38; 10.5%

0.957

 Died or LTFU

131/874; 15.0%

77/426; 18.1%

49/337; 14.5%

5/38; 13.2%

0.912

 Died or LTFU + VL > 150c

221/807; 27.4%

129/426; 30.2%

83/337; 24.6%

9/43; 20.9%

0.731

 Died or LTFU + VL > 1000c

188/807; 23.3%

111/426; 26.0%

68/337; 20.2%

9/43; 20.9%

0.773

Month 12b

690/874; 78.9%

364/467 77.9%

289/362; 79.8%

37/44; 84.1%

0.730

 with VL; still on treatment

459/690; 66.5%

219/364; 60.2%

207/289; 71.6%

33/37; 89.2%

0.006

 VL > 150#

61/459; 13.3%

30/219; 13.7%

27/207; 13.0%

4/33; 12.1%

1.000

 VL > 1000c

34/459; 7.4%

19/219; 8.7%

13/207; 6.3%

2/33; 6.1%

0.989

 Died or LTFU

184/874; 21.1%

103/322; 32.0%

73/280; 26.1%

7/40; 17.5%

0.654

 Died or LTFU + VL > 150c

245/643; 38.1%

133/322; 41.3%

100/280; 35.7%

11/40; 27.5%

0.623

 Died or LTFU + VL > 1000c

218/643; 33.9%

122/322; 37.9%

86/280; 30.7%

9/40; 22.5%

0.550

  1. aone additional patient was given abacavir; bstill remaining in the study at month 6 or 12; cAlthough 67 patients continued receiving their treatment (TDF: 41, ZDV: 25, and d4T:1) during the first 6 months follow up period, they were excluded from analyses due to lack of viral load data. Hence, in the ITT analysis 426, 337, and 43 TDF-, ZDV-, and d4T-treated patients were considered, respectively. Similarly, 231 patients were receiving their treatment (TDF: 145, ZDV: 82, and d4T:4) during the 12 months follow up period, but they were excluded from the analysis due to lack of viral load data. Hence, in the ITT analysis 322, 280, and 40 TDF-, ZDV-, and d4T-treated patients were considered, respectively