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Table 1 Characteristics of MIRU-VNTR clusters, included MIRU profile, identified Mycobacterium tuberculosis sub-lineage, patients’ country of origin, residence area in Portugal (including North, Central region, Lisbon and Tagus Valley, South and autonomous islands Madeira and Azores), patients’ risk factors (identified at diagnosis, namely alcohol abuse, drug misuse, residence in shelters or community residence and history of previous tuberculosis treatment)

From: A nationwide study of multidrug-resistant tuberculosis in Portugal 2014–2017 using epidemiological and molecular clustering analyses

Cluster MIRU-24 loci profile M.tuberculosis sublineage n Country of origin Residence area in Portugal Risk factors Disease site Previous TB treatment
1 243,244,331,234
424,153,334,332
Haarlem 4 Portugal North 1 alcohol abuse 3 pulmonary,
1 extra-pulmonary
No
2 244,233,352,644
425,153,353,823
Beijing 3 Guinea-Bissau 2 LVT,
1 Central
No 1 pulmonary,
1 extra-pulmonary,
1 unknown
1 no,
1 yes,
1 unknown
3 244,233,352,644
425,173,343,723
Beijing 3 Portugal LVT Injectable drugs use Pulmonary No
4 244,233,352,644
425,183,353,823
Beijing 2 Portugal 1 Madeira,
1 Central
No Pulmonary No
5 244,213,132,324
114,142,532,822
LAM 10 7 Portugal,
2 Cape Verde,
1 Mozambique
LVT 3 alcohol abuse,
2 injectable drug use,
1 shelter
7 pulmonary,
2 extra-pulmonary,
1 unknown
5 no,
4 yes,
1 unknown
6 244,213,232,324
116,143,532,822
LAM 6 5 Portugal,
1 Cape Verde
5 LVT,
1 Central
3 alcohol abuse,
2 injectable drug use
Pulmonary 4 no,
2 yes
7 244,213,232,424
116,143,532,822
LAM 14 12 Portugal,
2 Angola
9 LVT,
2 Central,
3 North
4 alcohol abuse,
4 injectable drug use
10 pulmonary,
3 extra-pulmonary,
1 unknown
6 no,
7 yes,
1 unknown