Skip to main content

Table 5 Vaccination and hazard ratios (HR) of influenza onset defined with ICD-10 codes only in Japanese subjects: time-dependent Cox hazard model

From: Influenza vaccination effectiveness for people aged under 65 years in Japan, 2013/2014 season: application of a doubly robust method to a large-scale, real-world dataset

  Age
1–4 years (n = 47,732) 5–12 years (n = 93,946) 13–19 years (n = 50,119) 20–64 years (n = 177,960)
Variable HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
2013/2014 season vaccination 0.705 (0.670–0.741) < 0.001 0.878 (0.849–0.908) < 0.001 1.022 (0.963–1.085) 0.468 0.855 (0.814–0.899) < 0.001
2012/2013 season vaccination 0.822 (0.779–0.868) < 0.001 1.008 (0.975–1.042) 0.646 1.076 (1.013–1.142) 0.017 0.986 (0.932–1.042) 0.616
Age 1.223 (1.199–1.247) < 0.001 0.936 (0.931–0.942) < 0.001 0.775 (0.762–0.789) < 0.001 0.985 (0.983–0.987) < 0.001
Insured persons (vs Dependents) 1.146 (0.747–1.756) 0.533 1.356 (1.277–1.439) < 0.001
Female (vs. Male) 0.931 (0.894–0.971) 0.001 0.984 (0.960–1.009) 0.220 0.820 (0.780–0.861) < 0.001 1.232 (1.166–1.302) < 0.001
Number of children aged 0 to 15 years in a family a 1.063 (1.035–1.092) < 0.001 0.955 (0.938–0.971) < 0.001 1.040 (1.007–1.074) 0.018 1.130 (1.107–1.153) < 0.001
Before influenza season
 High-risk condition 1.111 (1.062–1.163) < 0.001 1.085 (1.051–1.120) < 0.001 1.102 (1.021–1.190) 0.013 1.139 (1.084–1.198) < 0.001
Number of outpatient visits
 During office hours (per visit) 1.014 (1.010–1.018) < 0.001 1.007 (1.004–1.010) < 0.001 1.019 (1.011–1.027) < 0.001 1.016 (1.011–1.020) < 0.001
 Outside office hours (per visit) 1.021 (0.995–1.048) 0.122 0.992 (0.974–1.011) 0.394 0.980 (0.948–1.014) 0.243 0.998 (0.978–1.019) 0.868
Emergency hospitalization 1.330 (0.715–2.475) 0.367 0.504 (0.252–1.008) 0.053 1.630 (0.924–2.876) 0.092 0.812 (0.504–1.308) 0.392
During influenza season
 Preceding onset of influenza in family members 4.671 (4.458–4.893) < 0.001 2.261 (2.193–2.330) < 0.001 1.906 (1.786–2.034) < 0.001 4.530 (4.298–4.776) < 0.001