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Table 3 Aetiology of AUFI by site of patient recruitment

From: Diversity of infectious aetiologies of acute undifferentiated febrile illnesses in south and Southeast Asia: a systematic review

Organism

IP (n; %)

OP (n; %)

OP+IP (n; %)

Total (n; %)

Viral aetiologies

2721 (18.8)

5536 (36.7)

6631 (13.0)

14,888 (18.5)

Dengue

2377 (16.4)

1277 (8.5)

5857 (11.5)

9511 (11.8)

JE***

77 (0.5)

7 (0.0)

225 (0.4)

309 (0.4)

Influenza**

86 (0.6)

2077 (13.8)

351 (0.7)

2514 (3.1)

HINI

6 (0.0)

513 (3.4)

0 (0.0)

519 (0.6)

Chikungunya

54 (0.4)

224 (1.5)

177 (0.3)

455 (0.6)

Hepatitis A

0 (0.0)

62 (0.4)

11 (0.0)

73 (0.1)

Hepatitis B

4 (0.0)

267 (1.8)

1 (0.0)

272 (0.3)

Hepatitis E

2 (0.0)

1038 (6.9)

0 (0.0)

1040 (1.3)

Flavi virus

65 (0.4)

0 (0.0)

0 (0.0)

65 (0.1)

Para influenza 1

10 (0.1)

0 (0.0)

0 (0.0)

10 (0.0)

Para influenza 3

28 (0.2)

0 (0.0)

0 (0.0)

28 (0.0)

Hanta virus

1 (0.0)

71 (0.5)

1 (0.0)

73 (0.1)

HIV

11 (0.1)

0 (0.0)

8 (0.0)

19 (0.0)

Bacterial aetiologies

3340 (23.1)

3383 (22.4)

3662 (7.2)

10,385 (12.9)

Leptospirosis

989 (6.8)

2090 (13.9)

470 (0.9)

3549 (4.4)

Typhoid

406 (2.8)

912 (6.0)

1940 (3.8)

3258 (4.0)

Paratyphoid

57 (0.4)

0 (0.0)

0 (0.0)

57 (0.1)

Rickettsial diseases

1670 (11.6)

341 (2.3)

1232 (2.4)

3243 (4.0)

Scrub typhus

1449 (10.0)

245 (1.6)

1165 (2.3)

2859 (3.5)

Murine typhus

178 (1.2)

65 (0.4)

29 (0.1)

272 (0.3)

Spotted fever

43 (0.3)

31 (0.2)

38 (0.1)

112 (0.1)

Q fever

7 (0.0)

0 (0.0)

0 (0.0)

7 (0.0)

E coli

29 (0.2)

25 (0.2)

4 (0.0)

58 (0.1)

Burkholderia pseudomallei

17 (0.1)

3 (0.0)

3 (0.0)

23 (0.0)

Tuberculosis

36 (0.2)

0 (0.0)

7 (0.0)

43 (0.1)

Klebsiella pneumonia

2 (0.0)

0 (0.0)

2 (0.0)

4 (0.0)

Haemophilus influenza

9 (0.1)

0 (0.0)

0 (0.0)

9 (0.0)

Staph aureus

39 (0.3)

8 (0.1)

2 (0.0)

49 (0.1)

Strep pneumonia

73 (0.5)

2 (0.0)

0 (0.0)

75 (0.1)

Strep Gr A

1 (0.0)

0 (0.0)

1 (0.0)

2 (0.0)

Strep Gr C

0 (0.0)

0 (0.0)

1 (0.0)

1 (0.0)

Neisseria meningitis

5 (0.0)

2 (0.0)

0 (0.0)

7 (0.0)

Protozoa

990 (6.9)

57 (0.4)

1234 (2.4)

2281 (2.8)

Malaria

990 (6.9)

57 (0.4)

1234 (2.4)

2281 (2.8)

Fungal aetiologies

3 (0.0)

0 (0.0)

0 (0.0)

3 (0.0)

Yeast non-Cryptococci

2 (0.0)

0 (0.0)

0 (0.0)

2 (0.0)

Cryptococcus neoformans

1 (0.0)

0 (0.0)

0 (0.0)

1 (0.0)

Co infections

343 (2.4)

176 (1.2)

496 (1.0)

1015 (1.3)

Co infection*

331 (2.3)

169 (1.1)

270 (0.5)

770 (1.0)

Co infection†

12 (0.1)

7 (0.0)

220 (0.4)

239 (0.3)

Co infection‡

0 (0.0)

0 (0.0)

6 (0.0)

6 (0.0)

Unknown

7053 (48.8)

5923 (39.3)

39,036 (76.5)

52,012 (64.5)

Deaths

270 (71.4)

30 (7.9)

78 (20.6)

378 (100.0)

  1. IP Inpatients, OP Outpatients; ***JE- Japanese B Encephalitis, HAV Hepatitis A virus; HBV Hepatitis E virus, HEV Hepatitis E virus,
  2. **Influenza other than H1N1; *co-infection with two organisms; †co-infection with three organisms; ‡co-infection with more than three organisms
  3. The bold face shows the cumulative number of the stratified groups