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Table 2 Quality parameters of anti-HBc detection in oral fluid samples using commercial EIA according to locality of sample collection and serological profile

From: Utility of oral fluid samples for hepatitis B antibody detection in real life conditions

Profile TP FN TN FP Sensitivity% (CI%) Specificity% (CI%) PPV% (CI%) NPV% (CI %) k (CI)
GI) Ambulatory population (291) 72 30 178 11 70.6 (60.7–79.2) 94.2 (89.8–97.1) 86.7 (77.5–93.2) 85.6 (80.0–90.0) 67.7 (58.5–76.8)
G2) Various Brazilian regions (1005) 39 70 864 32 30.0 (21.2–39.9) 96.4 (95.0–97.5) 48.4 (37.3–59.6) 92.5 (91.6–93.3) 31.8 (19.2–44.3)
MidWest region subgroup (228) 8 29 190 1 21.6 (9.8–38.2) 99.5 (97.1–99.9) 88.9 (51.7–99.7) 86.8 (81.5–90.9) 30.4 (7.1–53.6)
North region subgroup (336) 17 31 279 9 35.4 (22.2–50.5) 96.9 (94.1–98.7) 65.4 (44.3–82.8) 90.0 (86.1–93.1) 39.9 (22.4–57.4)
Southeast region subgroup (441) 14 10 395 22 58.3 (36.6–77.9) 94.7 (92.1–96.7) 38.9 (27.2–51.9) 97.5 (96.1–98.4) 42.9 (23.9–61.9)
Active infection (57) 51 4 1 1 93.1 (83.3–98.1) 50.0 (1.26–98.7) 98.2 (93.1–99.5) 20.0 (4.46–57.2) 25.0 (0–87.9)
Anti-HBc isolate (37) 16 21 43.2 (27.1–60.5)
Previous HBV exposure (119) 44 75 36.9 (28.3–46.3)
Vaccinated HBV individuals (347) 328 19 94.5 (91.6–96.7)
Susceptible individuals (736) 713 23 96.9 (95.3–98.0)
All Individuals (1296) 111 100 1042 43 52.6 (45.6–59.5) 96.0 (94.7–97.1) 72.1 (64.3–79.0) 91.2 (89.4–92.8) 54.6 (47.6–61.6)
  1. Legends: TP True positive, FN False-negative, TN True negative, FP False-positive, PPV Positive Predictive Value, NPV Negative Predictive Value, k kappa index, n number of samples, CI confidence interval, –: not determined