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Table 2 Quality parameters of anti-HBc detection in oral fluid samples using commercial EIA according to locality of sample collection and serological profile

From: Utility of oral fluid samples for hepatitis B antibody detection in real life conditions

Profile

TP

FN

TN

FP

Sensitivity% (CI%)

Specificity% (CI%)

PPV% (CI%)

NPV% (CI %)

k (CI)

GI) Ambulatory population (291)

72

30

178

11

70.6 (60.7–79.2)

94.2 (89.8–97.1)

86.7 (77.5–93.2)

85.6 (80.0–90.0)

67.7 (58.5–76.8)

G2) Various Brazilian regions (1005)

39

70

864

32

30.0 (21.2–39.9)

96.4 (95.0–97.5)

48.4 (37.3–59.6)

92.5 (91.6–93.3)

31.8 (19.2–44.3)

MidWest region subgroup (228)

8

29

190

1

21.6 (9.8–38.2)

99.5 (97.1–99.9)

88.9 (51.7–99.7)

86.8 (81.5–90.9)

30.4 (7.1–53.6)

North region subgroup (336)

17

31

279

9

35.4 (22.2–50.5)

96.9 (94.1–98.7)

65.4 (44.3–82.8)

90.0 (86.1–93.1)

39.9 (22.4–57.4)

Southeast region subgroup (441)

14

10

395

22

58.3 (36.6–77.9)

94.7 (92.1–96.7)

38.9 (27.2–51.9)

97.5 (96.1–98.4)

42.9 (23.9–61.9)

Active infection (57)

51

4

1

1

93.1 (83.3–98.1)

50.0 (1.26–98.7)

98.2 (93.1–99.5)

20.0 (4.46–57.2)

25.0 (0–87.9)

Anti-HBc isolate (37)

16

21

43.2 (27.1–60.5)

Previous HBV exposure (119)

44

75

36.9 (28.3–46.3)

Vaccinated HBV individuals (347)

328

19

94.5 (91.6–96.7)

Susceptible individuals (736)

713

23

96.9 (95.3–98.0)

All Individuals (1296)

111

100

1042

43

52.6 (45.6–59.5)

96.0 (94.7–97.1)

72.1 (64.3–79.0)

91.2 (89.4–92.8)

54.6 (47.6–61.6)

  1. Legends: TP True positive, FN False-negative, TN True negative, FP False-positive, PPV Positive Predictive Value, NPV Negative Predictive Value, k kappa index, n number of samples, CI confidence interval, –: not determined