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Table 3 Molecular analysis of H5N6 virus isolates in Fujian Province, China

From: A study of the relationship between human infection with avian influenza a (H5N6) and environmental avian influenza viruses in Fujian, China

Viral Protein

Mutations#

Virus1

Virus2

Virus3

Virus4

Virus5

Virus6

Virus7

Virus8

Function

HA

Q226L*

Q

Q

Q

Q

Q

Q

Q

Q

Increased α2,6-SA recognition [22]

G228S*

G

G

G

G

G

G

G

G

Increased α2,6-SA recognition [22]

Cleavage site

RERRR

KR↓GL

RERRR

KR↓GL

RERRR

KR↓GL

RERRR

KR↓GL

RERRR

KR↓GL

RERRR

KR↓GL

REKRR

KR↓GL

RERRR

KR↓GL

Enhanced pathogenic effects in poultry [23]

NA

69-73deletion

No

No

No

No

No

No

No

No

Increased virulence in mice [24]

R294K/N294S

R

R

R

R

R

R

R

N

Oseltamivir and zanamivir resistance [25]

PB2

L89V

V

V

V

V

V

V

V

V

Enhanced pathogenicity in mice [26]

G309D

D

D

D

D

D

D

D

D

Increased virulence and replication in mice [27]

T339K

K

K

K

K

K

K

K

K

Increased virulence and replication in mice [27]

R477G

G

G

G

G

G

G

G

G

Increased virulence and replication in mice [27]

I495V

V

V

V

V

V

V

V

V

Increased virulence and replication in mice [27]

E627K

E

E

E

E

E

E

E

E

Mammalian host adaptation [28]

D701N

D

D

D

D

D

D

D

D

Enhanced transmission in guinea pigs [29]

PB1

H99Y

H

H

H

H

H

H

H

H

Enhanced H5 virus transmissible among ferrets [26]

I368V

I

I

I

V

I

I

I

I

Enhanced H5 virus transmissible among ferrets [26]

NS1

P42S

S

S

S

S

S

S

S

S

Increased virulence in mice [30]

D92E

E

E

E

D

E

E

D

D

Increased virulence in mice and pigs [27]

218-230deletion

Yes

Yes

Yes

Yes

Yes

Yes

No

No

Lack of PDZ domain binding motif:decreased virulence in mice [31]

M1

N30D

D

D

D

D

D

D

D

D

Increased virulence in mice [32]

T215A

A

A

A

A

A

A

A

A

Increased virulence in mice [32]

M2

S31N

S

S

S

N

S

S

S

S

Amantadine resistance [33]