Skip to main content

Advertisement

Table 3 Molecular analysis of H5N6 virus isolates in Fujian Province, China

From: A study of the relationship between human infection with avian influenza a (H5N6) and environmental avian influenza viruses in Fujian, China

Viral Protein Mutations# Virus1 Virus2 Virus3 Virus4 Virus5 Virus6 Virus7 Virus8 Function
HA Q226L* Q Q Q Q Q Q Q Q Increased α2,6-SA recognition [22]
G228S* G G G G G G G G Increased α2,6-SA recognition [22]
Cleavage site RERRR KR↓GL RERRR KR↓GL RERRR KR↓GL RERRR KR↓GL RERRR KR↓GL RERRR KR↓GL REKRR KR↓GL RERRR KR↓GL Enhanced pathogenic effects in poultry [23]
NA 69-73deletion No No No No No No No No Increased virulence in mice [24]
R294K/N294S R R R R R R R N Oseltamivir and zanamivir resistance [25]
PB2 L89V V V V V V V V V Enhanced pathogenicity in mice [26]
G309D D D D D D D D D Increased virulence and replication in mice [27]
T339K K K K K K K K K Increased virulence and replication in mice [27]
R477G G G G G G G G G Increased virulence and replication in mice [27]
I495V V V V V V V V V Increased virulence and replication in mice [27]
E627K E E E E E E E E Mammalian host adaptation [28]
D701N D D D D D D D D Enhanced transmission in guinea pigs [29]
PB1 H99Y H H H H H H H H Enhanced H5 virus transmissible among ferrets [26]
I368V I I I V I I I I Enhanced H5 virus transmissible among ferrets [26]
NS1 P42S S S S S S S S S Increased virulence in mice [30]
D92E E E E D E E D D Increased virulence in mice and pigs [27]
218-230deletion Yes Yes Yes Yes Yes Yes No No Lack of PDZ domain binding motif:decreased virulence in mice [31]
M1 N30D D D D D D D D D Increased virulence in mice [32]
T215A A A A A A A A A Increased virulence in mice [32]
M2 S31N S S S N S S S S Amantadine resistance [33]